The paper presents the results of theoretical and experimental studies into the development of scientific and methodological bases of environmentally-driven resource-saving technologies for mining waste processing. It is shown that the logic of reconstructing the natural cycles of natural resource equilibrium requires the inclusion of large-tonnage wastes in the status of their technogenic mineral resources in highly efficient, resource-efficient processing, which determines the need to develop innovative technologies for processing wastes very diverse in composition and properties within the framework of the principle of a systematic approach. The methodological basis of theoretical development of new environmentally oriented technologies for waste processing defines the method of scientific knowledge as an ascent from the abstract to the concrete and the construction of technologies according to the developed general algorithm. In accordance with the general methodological approach being developed, technologies have been developed for processing certain types of mining waste - off-balance copper ores from the dump, stale tailings of gold ore from the tailings; iron-zinc-containing blast furnace sludges of metallurgical production by combining several enrichment or concentration and hydrometallurgical methods. The developed resource-saving, environmentally friendly technologies provide the opportunity to involve previously unused resources of technogenic origin into efficient operation with obtaining conditioned metal-containing products and reduce environmental stress in regions with a developed mining and metallurgical industry.