Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis

Peng, Ankang; Liu, Shun-Zhi; Fang, Lü; Zhu, Zixing; Zhou, Yuan; Yue, Shanshan; Ma, Zejiang; Liu, Xiao‐Ang; Xue, Shilin; Qiu, Ying-Kun; Qi, Rong

doi:10.1016/j.ejphar.2022.174841

Cited by 14 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another pivotal player, the nuclear receptor FXR, assumed a key role in fatty acid metabolism [ 28 ]. Concomitantly, the downstream mediator of the FXR signaling pathway, SHP, exhibited discernible involvement [ 29 ]. A cascade emerged wherein SHP’s upregulation correlated with the inhibition of ACC1 transcription, thus abating fatty acid synthesis [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Alanyl-Glutamine Dipeptide Attenuates Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice by Improving Gut Microbiota Dysbiosis

Zheng,

Ying,

Shi

et al. 2023

Nutrients

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) manifests as a persistent liver ailment marked by the excessive buildup of lipids within the hepatic organ accompanied by inflammatory responses and oxidative stress. Alanyl-glutamine (AG), a dipeptide comprising alanine and glutamine, is commonly employed as a nutritional supplement in clinical settings. This research aims to evaluate the impact of AG on NAFLD triggered by a high-fat diet (HFD), while concurrently delving into the potential mechanisms underlying its effects. The results presented herein demonstrate a notable reduction in the elevated body weight, liver mass, and liver index induced by a HFD upon AG administration. These alterations coincide with the amelioration of liver injury and the attenuation of hepatic histological advancement. Furthermore, AG treatment manifests a discernible diminution in oil-red-O-stained regions and triglyceride (TG) levels within the liver. Noteworthy alterations encompass lowered plasma total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) concentrations, coupled with elevated high-density lipoprotein cholesterol (HDLC) concentrations. The mitigation of hepatic lipid accumulation resultant from AG administration is aligned with the downregulation of ACC1, SCD1, PPAR-γ, and CD36 expression, in conjunction with the upregulation of FXR and SHP expression. Concomitantly, AG administration leads to a reduction in the accumulation of F4/80-positive macrophages within the liver, likely attributable to the downregulated expression of MCP-1. Furthermore, AG treatment yields a decline in hepatic MDA levels and a concurrent increase in the activities of SOD and GPX. A pivotal observation underscores the effect of AG in rectifying the imbalance of gut microbiota in HFD-fed mice. Consequently, this study sheds light on the protective attributes of AG against HFD-induced NAFLD through the modulation of gut microbiota composition.

show abstract

Section: Discussionmentioning

confidence: 99%

Alanyl-Glutamine Dipeptide Attenuates Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice by Improving Gut Microbiota Dysbiosis

Zheng,

Ying,

Shi

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…This study highlighted the significance of triterpenoids in clarifying the hypoglycemic effects associated with I. obliquus. Peng et al (2022) showed that ethanol extracts from I. obliquus, containing inotodiol, lanosterol, and trametenolic acid, significantly improved lipid accumulation in mouse livers induced by a methionine-choline deficient diet or in human LO2 hepatocyte cells lines induced by oleic acid. These metabolites exhibited protective properties against non-alcoholic fatty liver disease (NAFLD) by mitigating lipid deposition effects, reversing liver weight loss, and reducing liver triglyceride content together with restoring lower levels of alanine transaminase (ALT) and aspartate aminotransferase (AST).…”

Section: Rutinmentioning

confidence: 99%

Biologically active secondary metabolites from white-rot fungi

Pinar,

Rodríguez-Couto

2024

Front. Chem.

View full text Add to dashboard Cite

In recent years, there has been a considerable rise in the production of novel metabolites derived from fungi compared to the ones originating from bacteria. These organic substances are utilized in various sectors such as farming, healthcare, and pharmaceutical. Since all dividing living cells contain primary metabolites, secondary metabolites are synthesized by utilizing intermediate compounds or by-products generated from the primary metabolic pathways. Secondary metabolites are not critical for the growth and development of an organism; however, they exhibit a variety of distinct biological characteristics. White-rot fungi are the only microorganisms able to decompose all wood components. Hence, they play an important role in both the carbon and nitrogen cycles by decomposing non-living organic substrates. They are ubiquitous in nature, particularly in hardwood (e.g., birch and aspen) forests. White-rot fungi, besides ligninolytic enzymes, produce different bioactive substances during their secondary metabolism including some compounds with antimicrobial and anticancer properties. Such properties could be of potential interest for the pharmaceutical industries. Considering the importance of the untapped biologically active secondary metabolites from white-rot fungi, the present paper reviews the secondary metabolites produced by white-rot fungi with different interesting bioactivities.

show abstract

“…Table S1 † summarizes these polyphenol extracts. [105][106][107][108][110][111][112][113][114]116,[119][120][121][122][123][124][125][126][127]130 Curcumin is a natural polyphenol beneficial to patients with NAFLD. It has been proved that curcumin of 50/100 mg per kg can be used as an activator of FXR to increase the transcription of CYP7A1 in C57BL/6 mice.…”

Section: Polyphenols Can Activate/inhibit Fxr and Tgr5 But The Mechan...mentioning

confidence: 99%

Dietary polyphenols maintain homeostasis via regulating bile acid metabolism: a review of possible mechanisms

Liu,

Huang,

Zhang

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis

Cited by 14 publications

References 32 publications

Alanyl-Glutamine Dipeptide Attenuates Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice by Improving Gut Microbiota Dysbiosis

Alanyl-Glutamine Dipeptide Attenuates Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice by Improving Gut Microbiota Dysbiosis

Biologically active secondary metabolites from white-rot fungi

Dietary polyphenols maintain homeostasis via regulating bile acid metabolism: a review of possible mechanisms

Contact Info

Product

Resources

About