Inorganic and organic–inorganic composite nanoparticles with potential biomedical applications: synthesis challenges for enhanced performance

Varanda, Laudemir Carlos; Souza, Caio Guilherme Secco de; Perecin, Caio José; Moraes, Daniel A.; Queiróz, Daniely Ferreira de; Neves, Herbert Rodrigo; Souza, João Batista; Silva, Mônica Freitas da; Albers, Rebecca Faggion; Silva, Tiago Luis da

doi:10.1016/b978-0-12-818431-8.00004-0

Cited by 15 publications

(9 citation statements)

References 252 publications

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“…It is a well-established method of synthesis of nanocomposites in an aqueous solution [53]. It is a rapid and straightforward preparation at low temperatures, in which the products are generally insoluble species formed under conditions of high supersaturation.…”

Section: Co-precipitationmentioning

confidence: 99%

Synthesis, Characterization, and Photocatalytic Performance of ZnO–Graphene Nanocomposites: A Review

et al. 2020

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ZnO is an exciting material for photocatalysis applications due to its high activity, easy accessibility of raw materials, low production costs, and nontoxic. Several ZnO nano and microstructures can be obtained, such as nanoparticles, nanorods, micro flowers, microspheres, among others, depending on the preparation method and conditions. ZnO is a wide bandgap semiconductor presenting massive recombination of the generated charge carriers, limiting its photocatalytic efficiency and stability. It is common to mix it with metal, metal oxide, sulfides, polymers, and nanocarbon-based materials to improve its photocatalytic behavior. Therefore, ZnO–nanocarbon composites formation has been a viable alternative that leads to new, more active, and stable photocatalytic systems. Mainly, graphene is a well-known two-dimensional material, which could be an excellent candidate to hybridize with ZnO due to its excellent physical and chemical properties (e.g., high specific surface area, optical transmittance, and thermal conductivity, among others). This review analyses ZnO–graphene nanocomposites’ recent advances, addressing the synthesis methods and the resulting structural, morphological, optical, and electronic properties. Moreover, we examine the ZnO–graphene composites’ role in the photocatalytic degradation of organic/inorganic pollutants.

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Section: Co-precipitationmentioning

confidence: 99%

Synthesis, Characterization, and Photocatalytic Performance of ZnO–Graphene Nanocomposites: A Review

et al. 2020

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“…DLS analyses show that when the particles are dispersed in water, they are organized in aggregates with a Z-average (determined by the intensity of scattered light) of 206.6 nm and a number mean of 58.6 nm. The shape and size are typical of the coprecipitation route, as well as the slight aggregation of the suspension [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…In fact, all biomedical applications require peculiar surface coatings of the SPIONs, which also must be nontoxic and biocompatible, to stabilize them against aggregation and oxidation [ 18 ], as well as to functionalize them for specific tasks [ 19 ]. Encapsulation with appropriate polymers is a good path to obtain composite materials that combine the properties of inorganic and organic units [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying

et al. 2022

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Composites of magnetite nanoparticles encapsulated with polymers attract interest for many applications, especially as theragnostic agents for magnetic hyperthermia, drug delivery, and magnetic resonance imaging. In this work, magnetite nanoparticles were synthesized by coprecipitation and encapsulated with different polymers (Eudragit S100, Pluronic F68, Maltodextrin, and surfactants) by nano spray drying technique, which can produce powders of nanoparticles from solutions or suspensions. Transmission and scanning electron microscopy images showed that the bare magnetite nanoparticles have 10.5 nm, and after encapsulation, the particles have approximately 1 μm, with size and shape depending on the material’s composition. The values of magnetic saturation by SQUID magnetometry and mass residues by thermogravimetric analysis were used to characterize the magnetic content in the materials, related to their magnetite/polymer ratios. Zero-field-cooling and field-cooling (ZFC/FC) measurements showed how blocking temperatures of the powders of the composites are lower than that of bare magnetite, possibly due to lower magnetic coupling, being an interesting system to study magnetic interactions of nanoparticles. Furthermore, studies of cytotoxic effect, hydrodynamic size, and heating capacity for hyperthermia (according to the application of an alternate magnetic field) show that these composites could be applied as a theragnostic material for a non-invasive administration such as nasal.

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“…26,27 However, the effective coupling of the polymer to the SPION surface demands strong binding. 28 Hydroxyl groups are recognized to couple extensively onto magnetite due to their interactions with incomplete coordination of Fe−O species on the oxide surface. The bio-occurring dopamine molecule presents two hydroxyls in its catechol group, enabling an efficient bidentate coupling with the magnetite surface.…”

Section: Introductionmentioning

confidence: 99%

“…However, the effective coupling of the polymer to the SPION surface demands strong binding . Hydroxyl groups are recognized to couple extensively onto magnetite due to their interactions with incomplete coordination of Fe–O species on the oxide surface.…”

Section: Introductionmentioning

confidence: 99%

Magnetite Nanoparticles Coated with Biodegradable Zwitterionic Polymers as Multifunctional Nanocomposites for Drug Delivery and Cancer Treatment

Perecin

Sponchioni

Auriemma

et al. 2022

ACS Appl. Nano Mater.

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Tailor-made materials for biomedical applications can be constructed with different building blocks to confer multiple functions on one platform. Here, we demonstrate the facile synthesis of magnetite-biodegradable polymer nanocomposites combining superparamagnetism with the possibility of loading and controlling the release of a lipophilic drug. The magnetite nanoparticles were synthesized by reduction–precipitation and used as nuclei to grow a biodegradable zwitterionic shell. The copolymer used for this scope comprises a hydrophobic block made of a biodegradable ε-caprolactone-based macromonomer (CL n ) with three different degrees of polymerization (DP n , n = 3, 5, and 7) obtained by ring-opening polymerization (ROP). Dopamine molecules were attached to the end of this CL n oligomer (CL n Dopa), conferring a specific affinity for the magnetite surface. A hydrophilic zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) block (PMPC) was included by reversible addition–fragmentation chain transfer (RAFT) polymerization to add colloidal stability and water dispersibility to the copolymer. This PMPC was chain-extended with CL n Dopa via RAFT polymerization targeting four different DP m (m = 10, 20, 30, and 40), resulting in a library of 12 copolymers. A facile nanoprecipitation process produced copolymer nanoparticles and copolymer-coated magnetite nanostructures. Physicochemical characterization confirmed the inorganic–organic composite nature. The copolymer-coated magnetic materials showed water stability, superparamagnetic behavior, and appropriate hyperthermic ability under an alternate magnetic field. Biological assays using HeLa cells showed high biocompatibility and efficient nanoparticle uptake. In addition, a sustained release of dexamethasone, used as a model drug encapsulated in the polymer shell, and local heating as a dual functional material could be accessed.

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Inorganic and organic–inorganic composite nanoparticles with potential biomedical applications: synthesis challenges for enhanced performance

Cited by 15 publications

References 252 publications

Synthesis, Characterization, and Photocatalytic Performance of ZnO–Graphene Nanocomposites: A Review

Synthesis, Characterization, and Photocatalytic Performance of ZnO–Graphene Nanocomposites: A Review

Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying

Magnetite Nanoparticles Coated with Biodegradable Zwitterionic Polymers as Multifunctional Nanocomposites for Drug Delivery and Cancer Treatment

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