Inorganic hybrid nanoparticles in cancer theranostics: understanding their combinations for better clinical translation

Shetty, Aishwarya; Chandra, Sudeshna

doi:10.1016/j.mtchem.2020.100381

Cited by 32 publications

(14 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, researchers are forming hybrid magnetic nanoparticles to optimize the optical or chemical properties. This can be the addition of gold, manganese, sulfides of copper, or tungsten, which increases the particles’ magnetism and relaxivity whrn compared with non-doped SPIONS [ 48 ]. By combining different material characteristics, more effective and less toxic theranostics can be developed.…”

Section: Treatmentmentioning

confidence: 99%

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

et al. 2021

View full text Add to dashboard Cite

The use of magnetism in medicine has changed dramatically since its first application by the ancient Greeks in 624 BC. Now, by leveraging magnetic nanoparticles, investigators have developed a range of modern applications that use external magnetic fields to manipulate biological systems. Drug delivery systems that incorporate these particles can target therapeutics to specific tissues without the need for biological or chemical cues. Once precisely located within an organism, magnetic nanoparticles can be heated by oscillating magnetic fields, which results in localized inductive heating that can be used for thermal ablation or more subtle cellular manipulation. Biological imaging can also be improved using magnetic nanoparticles as contrast agents; several types of iron oxide nanoparticles are US Food and Drug Administration (FDA)-approved for use in magnetic resonance imaging (MRI) as contrast agents that can improve image resolution and information content. New imaging modalities, such as magnetic particle imaging (MPI), directly detect magnetic nanoparticles within organisms, allowing for background-free imaging of magnetic particle transport and collection. “Lab-on-a-chip” technology benefits from the increased control that magnetic nanoparticles provide over separation, leading to improved cellular separation. Magnetic separation is also becoming important in next-generation immunoassays, in which particles are used to both increase sensitivity and enable multiple analyte detection. More recently, the ability to manipulate material motion with external fields has been applied in magnetically actuated soft robotics that are designed for biomedical interventions. In this review article, the origins of these various areas are introduced, followed by a discussion of current clinical applications, as well as emerging trends in the study and application of these materials.

show abstract

Section: Treatmentmentioning

confidence: 99%

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Due to the large surface area for conjugation of various molecules, inorganic NPs have also been used for drug targeting delivery, thus enabling them to be suitable as a desired theranostic agent. [ 236 ]…”

Section: Inorganic‐based Nanostructured Carriersmentioning

confidence: 99%

“…As a result, Au nanostructures have been one of the most frequently explored inorganic components to build O/I hybrid materials in biomedical applications. [ 46,236 ] This is attributed to the biomedical merits, such as easy fabrication, biocompatibility, low polydispersity, tunable plasmonic properties, and self‐therapeutic properties. [ 239 ] Generally, these properties are largely dependent on geometrical parameter (size, shape, and length).…”

Section: Inorganic‐based Nanostructured Carriersmentioning

confidence: 99%

“…[ 324 ] In the last decade, MSNs have gained attention for drug delivery, gene transfection, and immunotherapy. [ 325 ] Since the first conceptualization of using MSNs as carriers for drug delivery in 2001, various types of MSNs have been extensively synthesized and used as drug delivery systems due to the following benefits [ 46,236,256,325 ] : i) A tunable particle size (50–300 nm) for facilitating the cell uptake, ii) a large internal pore volume and a high specific surface area for the drug loading, iii) a distinctive porous structure for prevention of premature release of the loaded cargos, iv) a bioinert property along with excellent biocompatibility at a wide concentration range, v) the surface can be readily functionalized with other biomolecules, endowing MSNs with an active targeting ability.…”

Section: Inorganic‐based Nanostructured Carriersmentioning

confidence: 99%

See 1 more Smart Citation

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

View full text Add to dashboard Cite

Since the conceptualization of nanomedicine, numerous nanostructure‐mediated drug formulations have progressed into clinical trials for treating cancer. However, recent clinical trial results indicate such kind of drug formulations has a limited improvement on the antitumor efficacy. This is due to the biological barriers associated with those formulations, for example, circulation stability, extravasation efficiency in tumor, tumor penetration ability, and developed multi‐drug resistance. When employing for nanomedicine formulations, pristine organic‐based and inorganic‐based nanostructures have their own limitations. Accordingly, organic/inorganic (O/I) hybrids have been developed to integrate the merits of both, and to minimize their intrinsic drawbacks. In this context, the recent development in O/I hybrids resulting from a self‐assembly strategy will be introduced. Through such a strategy, organic and inorganic building blocks can be self‐assembled via either chemical covalent bonds or physical interactions. Based on the self‐assemble procedure, the hybridization of four organic building blocks including liposomes, micelles, dendrimers, and polymeric nanocapsules with five functional inorganic nanoparticles comprising gold nanostructures, magnetic nanoparticles, carbon‐based materials, quantum dots, and silica nanoparticles will be highlighted. The recent progress of these O/I hybrids in advanced modalities for combating cancer, such as, therapeutic agent delivery, photothermal therapy, photodynamic therapy, and immunotherapy will be systematically reviewed.

show abstract

“…This causes the formation of protein 'corona' on the surface of the NPs. Research found that this corona could alter the polymeric NPs properties and functions such as biodistribution, stability, pharmacokinetics, immune system, and toxicity [195,196]. Furthermore, numerous in vitro and in vivo animal studies have been done to understand the polymeric NPs mechanisms on specific cancer treatments.…”

Section: Limitation and Challengesmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

Gels

View full text Add to dashboard Cite

With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

show abstract

Inorganic hybrid nanoparticles in cancer theranostics: understanding their combinations for better clinical translation

Cited by 32 publications

References 127 publications

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Contact Info

Product

Resources

About