Inorganic Mercury and Methylmercury Inhibit the Ca_v3.1 Channel Expressed in Human Embryonic Kidney 293 Cells by Different Mechanisms

Abstract

Part of the neurotoxic effects of inorganic mercury (Hg 2ϩ ) and methylmercury (MeHg) was attributed to their interaction with voltage-activated calcium channels. Effects of mercury on Ttype calcium channels are controversial. Therefore, we investigated effects of Hg 2ϩ and MeHg on neuronal Ca v 3

Metals and apoptosis: Recent developments

“…Recently, a few interesting reports have emerged linking apoptosis with inhibition of Ca(V) 3.1 (T type) calcium channel. Interaction of inorganic mercury with this channel may significantly contribute to neuronal symptoms of mercury poisoning during both acute poisoning and long-term environmental exposure [163]. Induction of apoptosis in the tubular epithelial Madin-Darby canine kidney (MDCK) cell line was also investigated [164].…”

Effects of methylmercury on spinal cord afferents and efferents—A review

“…Although MeHg blocks current carried through voltage-gated Ca 2+ channels (Hajela et al, 2003, Leonhardt, et al, 1996b, Peng et al, 2002, Shafer and Atchison, 1991, Sirois and Atchison, 2000, Tarabová et al, 2006), it also stimulates release of Ca 2+ from intracellular stores to increase cytosolic Ca 2+ levels (Castoldi et al, 1997, Hare and Atchison, 1995a, Harris and Baum, 1980, Limke and Atchison, 2002, Limke et al, 2003, Marty and Atchison, 1997, 1998, Sarafian, 1993). Regulation of intracellular Ca 2+ is critical given its central role in basic neuronal functions, including protein synthesis, growth and differentiation, gene expression and synaptic transmission.…”

Polyrhodanine modified anodic aluminum oxide membrane for heavy metal ions removal

“…The heavy metal can cause various fatal diseases [3,4]. For example, mercury is well-known as neurotoxin that can induce insanity, paralysis, and death [3].…”