Inorganic nanoparticles: A potential cancer therapy for human welfare

Pugazhendhi, Arivalagan; Edison, Thomas Nesakumar Jebakumar Immanuel; Karuppusamy, Indira; Brindhadevi, Kathirvel

doi:10.1016/j.ijpharm.2018.01.034

Cited by 263 publications

(146 citation statements)

References 102 publications

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“…Pulgazhendi et al emphasised that chitosan nanoparticles penetrate the cancerous cells membrane, leading to DNA damage and defects in the genes of the cells. 9 Furthermore, Shanmuganathan et al reported that the apoptosis of tumour cells due to therapy using nanoparticles of chitosan and its derivative is the result of the nanoparticles interfering with cell growth and metabolism. 8 The highest concentration (100 µg mL −1 ) for OGEO, OGEO-MeOH, CSNPs, TMCNPs, OGEO-CSNPs and OGEO-TMCNPs decreased the viability of cancer cells to 44.25%, 64.19%, 63.56%, 38.53%, 77.19% and 37.44%, respectively ( Figure 13B).…”

Section: Gratissimum Methanolic Extract Eos and Eo-loaded Nanopartimentioning

confidence: 99%

“…8 This represents a major drawback in the diagnosis and treatment of cancer and other diseases and has led to the development of nanomedicine an area of nanotechnology involving the manipulation of matter within the nanoscale range of 1-100 nm at 10 −9 dimension. 9 The medical applications of nanotechnology involve the use of both chemical and physical methods for the synthesis of organic and inorganic nanoparticles that are biocompatible for transporting drugs with high target specificity. 8 Nanoparticles are capable of improving drug permeation across cell membranes 10 and controlling the release of the encapsulated drug.…”

Section: Introductionmentioning

confidence: 99%

“…8 Nanoparticles are capable of improving drug permeation across cell membranes 10 and controlling the release of the encapsulated drug. 9 Chitosan is currently being explored due to its unique properties as a nanocarrier for the delivery of antimicrobial, anticancer and antioxidative agents of natural origin, such as plant essential oils (EOs). [8][9][10][11] Ocimum gratissimum (OG) is a herbaceous plant belonging to the Lamiaceae family.…”

Section: Introductionmentioning

confidence: 99%

“…9 Chitosan is currently being explored due to its unique properties as a nanocarrier for the delivery of antimicrobial, anticancer and antioxidative agents of natural origin, such as plant essential oils (EOs). [8][9][10][11] Ocimum gratissimum (OG) is a herbaceous plant belonging to the Lamiaceae family. This plant is indigenous to tropical, savanna and coastal areas.…”

Section: Introductionmentioning

confidence: 99%

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Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity

Onyebuchi¹,

Kavaz²

2019

IJN

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Background: The encapsulation of plant essential oils (EOs) with polymeric materials (e.g. chitosan (CS) and N, N, N-trimethyl chitosan (TMC)) and the further reduction of the polymers into their nano sizes are gaining research interest in nanotechnology due to potential applications in medical drug delivery systems as well as the food and pharmaceutical industry. The present study reports a novel approach for the synthesis of Ocimum gratissimum essential oil (OGEO)-loaded CS and TMC nanoparticles with distinct bioactive and physiochemical properties. Methods: The OGEO-loaded CS and TMC nanoparticles were characterised using various microscopic and spectroscopic techniques. The bioactive compounds in Ocimum gratissimum methanolic extract (OG-MeOH) and EOs was evinced with gas chromatography-mass spectrometry (GC-MS). Total phenolic content (TPC) of OGEO and OG-MeOH was determined using the Folin-Ciocalteu method. The in vitro drug release kinetic pattern was ascertained by membrane dialysis, while antioxidant activity was determined by the 2,2-diphenyl-1picrylhydrozyl (DPPH) free radical scavenging method. The disc diffusion method was used for antibacterial activity evaluation, while MTT and a trypan blue dye exclusion assay were used to assess cytotoxic activity on MDA-MB-231 breast cancer cells. Results: GC-MS analysis revealed components that have not been previously reported for Ocimum gratissimum. The maximum OGEO cumulative drug release percentage in vitro was observed at pH 3 for both OGEO-loaded chitosan nanoparticles (OGEO-CSNPs) and OGEOloaded N, N, N-trimethyl chitosan nanoparticles (OGEO-TMCNPs). The antioxidant activity of OGEO-CSNPs and OGEO-TMCNPs never reached a steady state after 75 h. OGEO-TMCNPs exhibited antibacterial activity at a lower concentration for both Gram-negative and Gram-positive food pathogens. In vitro cytotoxicity revealed the increased toxicity of OGEO-TMCNPs on MDA-MB-231 breast cancer cell lines. Conclusion: OGEO-loaded CS and TMC nanoparticles were synthesised using a novel material optimisation approach. The synthesised nanoparticles have shown a promising application in the pharmaceutical and food industries.

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Section: Gratissimum Methanolic Extract Eos and Eo-loaded Nanopartimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity

Onyebuchi¹,

Kavaz²

2019

IJN

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“…The survival rate of TB-infected animals following the combined treatment with isoniazid and AgNP was 95% and 35% in the group receiving AgNP only, compared with 100% mortality in the TB-infected control group. 133 One of the potential drawbacks of AgNPs, as four most of the inorganic nanoparticles, is their toxicity which may limit their usage in a biological context, [240][241][242] but despite the extension of use in the last decades, the evidence for the toxicity of AgNPs is still unclear. 243 However, an in depth discussion regarding the toxicity of AgNP is something that goes beyond the purpose of this manuscript.…”

Section: In Vivo Preclinical and Clinical Studiesmentioning

confidence: 99%

Silver Nanoparticles for the Therapy of Tuberculosis

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

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Inorganic Nanoparticles Applied as Functional Therapeutics

Liu¹,

Kim

et al. 2020

Adv Funct Materials

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Inorganic nanoparticles (NPs) offer significant advantages to the biomedical field owing to their large surface area, controllable structures, diverse surface chemistry, and unique optical and physical properties. Researchers worldwide have shown that inorganic NPs and the released metal ions can act as therapeutic agents in targeted tissues or to cure various diseases without acute toxicity. In this progress report, the recent developments in inorganic NPs with different compositions directly used as therapeutics are discussed. First, the recent convergence of nanotechnology and biotechnology in biomedical applications as well as the unique functions, features, and advantages of inorganic NPs in biomedical applications are summarized. Thereafter, the biological effects of inorganic compositions in NPs which include balancing the intracellular redox environment, regulating the specific cellular signaling and cellular behaviors, and apoptosis are explained. In addition, the emerging therapeutic applications of inorganic NPs in various diseases are exemplified. Finally, the perspectives and challenges for overcoming the weaknesses of inorganic NPs as therapeutics are discussed. By carefully considering and investigating the biological effects of inorganic NPs and metal ions released from NPs, more promising inorganic NPs based therapeutic agents can be developed.

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Inorganic nanoparticles: A potential cancer therapy for human welfare

Cited by 263 publications

References 102 publications

<p>Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of <em>Ocimum Gratissimum</em> Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity</p>

<p>Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of <em>Ocimum Gratissimum</em> Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity</p>

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Inorganic Nanoparticles Applied as Functional Therapeutics

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