Inorganic nanoparticles for the theranostics of cancer

Verma, Jyoti; Lal, Sumit; Noorden, C. J. F. Van

doi:10.1515/ejnm-2015-0024

Cited by 21 publications

(8 citation statements)

References 36 publications

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“…Early work in the use of antibody–decorated nanoparticles for imaging applications encountered problems due to specific accumulation, with the limiting step found to be extravasation of the nanoparticles from the vasculature, rather than cell binding. 1 , 4 , 7 , 41 , 93 , 102 Whilst this is also a problem for therapeutic nanoparticles, it is more apparent for imaging applications where the utility is highly dependent on achieving high resolution between the target site and the background. In an attempt to tackle this problem, recent work has focused on the use of smaller antibody fragments as targeting ligands.…”

Section: Nanoparticle–antibody Fragment Conjugates In Biomedicinementioning

confidence: 99%

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

2017

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Section: Nanoparticle–antibody Fragment Conjugates In Biomedicinementioning

confidence: 99%

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

2017

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“…Metallic NPs feature unique physical properties such as high ratio-to-surface area and volume. Moreover, the confinement effect confers reactivity as well as mechanical, electromagnetic, chemical and optical properties that differ from those of the bulk metals [17,18,19]. Indeed, particles properties change drastically at the nanometer scale [11].…”

Section: Introductionmentioning

confidence: 99%

Silver-Based Plasmonic Nanoparticles for and Their Use in Biosensing

et al. 2019

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The localized surface plasmon resonance (LSPR) property of metallic nanoparticles is widely exploited for chemical and biological sensing. Selective biosensing of molecules using functionalized nanoparticles has become a major research interdisciplinary area between chemistry, biology and material science. Noble metals, especially gold (Au) and silver (Ag) nanoparticles, exhibit unique and tunable plasmonic properties; the control over these metal nanostructures size and shape allows manipulating their LSPR and their response to the local environment. In this review, we will focus on Ag-based nanoparticles, a metal that has probably played the most important role in the development of the latest plasmonic applications, owing to its unique properties. We will first browse the methods for AgNPs synthesis allowing for controlled size, uniformity and shape. Ag-based biosensing is often performed with coated particles; therefore, in a second part, we will explore various coating strategies (organics, polymers, and inorganics) and their influence on coated-AgNPs properties. The third part will be devoted to the combination of gold and silver for plasmonic biosensing, in particular the use of mixed Ag and AuNPs, i.e., AgAu alloys or Ag-Au core@shell nanoparticles will be outlined. In the last part, selected examples of Ag and AgAu-based plasmonic biosensors will be presented.

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“…Targeted drug delivery (TDD) nanosystems increase the therapeutic activity of the drug by improving its solubility and stability and enhancing the amount of drug delivered to the target tissue (Maghsoudnia et al 2020). Many types of DOX carriers are known ranging from metal or carbon nanoparticles, to lipid carriers such as liposomes and QDs (nanocrystals) (Li et al 2017, Silverman et al 2013, Verma et al 2015. The latter have enormous potential in both therapy and diagnostics.…”

Section: Quantitative Analysis Of the Qd-fa Nanocarriers And Qd-fa-domentioning

confidence: 99%

Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

et al. 2021

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Background Lung cancer is one of the most frequently diagnosed cancers all over the world and is also one of the leading causes of cancer-related mortality. The main treatment option for small cell lung cancer, conventional chemotherapy, is characterized by a lack of specificity, resulting in severe adverse effects. Therefore, this study aimed at developing a new targeted drug delivery (TDD) system based on Ag–In–Zn–S quantum dots (QDs). For this purpose, the QD nanocrystals were modified with 11-mercaptoundecanoic acid (MUA), L-cysteine, and lipoic acid decorated with folic acid (FA) and used as a novel TDD system for targeting doxorubicin (DOX) to folate receptors (FARs) on adenocarcinomic human alveolar basal epithelial cells (A549). NIH/3T3 cells were used as FAR-negative controls. Comprehensive physicochemical, cytotoxicity, and genotoxicity studies were performed to characterize the developed novel TDDs. Results Fourier transformation infrared spectroscopy, dynamic light scattering, and fluorescence quenching confirmed the successful attachment of FA to the QD nanocrystals and of DOX to the QD–FA nanocarriers. UV–Vis analysis helped in determining the amount of FA and DOX covalently anchored to the surface of the QD nanocrystals. Biological screening revealed that the QD–FA–DOX nanoconjugates had higher cytotoxicity in comparison to the other forms of synthesized QD samples, suggesting the cytotoxic effect of DOX liberated from the QD constructs. Contrary to the QD–MUA–FA–DOX nanoconjugates which occurred to be the most cytotoxic against A549 cells among others, no such effect was observed for NIH/3T3 cells, confirming FARs as molecular targets. In vitro scratch assay also revealed significant inhibition of A549 cell migration after treatment with QD–MUA–FA–DOX. The performed studies evidenced that at IC50 all the nanoconjugates induced significantly more DNA breaks than that observed in nontreated cells. Overall, the QD–MUA–FA–DOX nanoconjugates showed the greatest cytotoxicity and genotoxicity, while significantly inhibiting the migratory potential of A549 cells. Conclusion QD–MUA–FA–DOX nanoconjugates can thus be considered as a potential drug delivery system for the effective treatment of adenocarcinomic human alveolar basal epithelial cells.

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Inorganic nanoparticles for the theranostics of cancer

Cited by 21 publications

References 36 publications

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

Silver-Based Plasmonic Nanoparticles for and Their Use in Biosensing

Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

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