Inorganic nitrate supplementation may improve diastolic function and the O2 cost of exercise in cancer survivors: a pilot study

Turpin, Vanessa-Rose G.; Lovoy, Garrett M.; Parr, Shannon K.; Hammond, Stephen T.; Post, H.; Caldwell, Jacob T.; Banister, Heather R.; Scheuermann, Britton; Colburn, Trenton D.; Ade, Carl J.

doi:10.1007/s00520-022-07520-6

Cited by 1 publication

(1 citation statement)

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“…On the other hand, resveratrol was capable of reducing the adverse effects of doxorubicin on LV contractility in a murine model [102]. Finally, in a small cohort of cancer survivors, subjects who received inorganic dietary nitrate supplementation (that can be found in green leafy vegetables [103]), despite a similar LVEF, showed a better left ventricular strain rate during early diastole [104].…”

Section: Cardiac Evaluation Regarding Diet In Masld and Cancermentioning

confidence: 98%

Standard and New Echocardio Techniques, Such as Global Longitudinal Strain, to Monitor the Impact of Diets on Cardiovascular Diseases and Heart Function

Sartorio,

Dal Pont,

Romano

2024

Nutrients

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“The Seven Countries Study”, published in 1984, was the first study to find a correlation between diet and mortality related to cardiovascular diseases (CVDs). Since then, many investigations have addressed the relationship between type of diet, or specific nutrients, and CVDs. Based on these findings, some traditional dietary models, such as the Mediterranean or Nordic diet, are recommended to prevent CVDs. Meanwhile, new diets have been proposed for optimal nutrition therapy, for example, the Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean–DASH Intervention Diet for Neurodegenerative Delay (MIND). The main outcomes evaluated after implementing these dietary models are as follows: CVD-related death; the development of specific CVDs, such as myocardial infarction and hypertension; or biochemical parameters related to CVDs, i.e., non-HDL cholesterol, C-reactive protein (CPR) and homocysteine. However, the early impact of diet on heart functionality is less evaluated. Recently, the echographic measurement of left ventricle (LV) deformation by global longitudinal strain (GLS) has been introduced as a novel marker of clinical and subclinical cardiac dysfunction. This technology allows a subclinical evaluation of heart functionality since, differently from the traditional evaluation of left ventricle ejection fraction (LVEF), it is capable of detecting early myocardial dysfunction. In this review, we analyzed the available studies that correlate dietetic regimens to cardiovascular diseases, focusing on the relevance of LV strain to detect subclinical myocardial alteration related to diet. Evidence is presented that DASH and MIND can have a positive impact on heart functionality and that myocardial strain is useful for early detection of diet-related changes in cardiac function.

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Section: Cardiac Evaluation Regarding Diet In Masld and Cancermentioning

confidence: 98%