Inorganic–organic hybrid materials to detect urinary biomarkers: recent progress and future prospects

Hu, Qi; Tang, Youhong

doi:10.1039/d2qm00213b

Cited by 5 publications

(1 citation statement)

References 166 publications

(151 reference statements)

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“…Human serum albumin (HSA), as the most abundant plasma protein, (55–60%) [ 1 ], is a significant biomarker for clinical diagnosis, particularly on renal disease and proteinuria [ 2 ]. It also plays vital roles in many physiological functions, including the maintenance of normal plasma colloidal osmotic activity [ 3 ], the specific attractive force for the retention of positively charged solutes in blood vessels [ 4 ], and good scavenging ability towards free radicals [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device

Luo

Tohl

et al. 2023

Molecules

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Hydrogels have various promising prospects as a successful platform for detecting biomarkers, and human serum albumin (HSA) is an important biomarker in the diagnosis of kidney diseases. However, the difficult-to-control passive diffusion kinetics of hydrogels is a major factor affecting detection performance. This study focuses on using hydrogels embedded with aggregation-induced emission (AIE) fluorescent probe TC426 to detect HSA in real time. The vortex fluidic device (VFD) technology is used as a rotation strategy to control the reaction kinetics and micromixing during measurement. The results show that the introduction of VFD could significantly accelerate its fluorescence response and effectively improve the diffusion coefficient, while VFD processing could regulate passive diffusion into active diffusion, offering a new method for future sensing research.

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Section: Introductionmentioning

confidence: 99%

Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device

Luo

Tohl

et al. 2023

Molecules

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Fluorogen‐Functionalized Mesoporous Silica Hybrid Sensing Materials: Applications in Cu²⁺ Detection

Xu,

Jiang,

Liu

et al. 2023

Chemistry A European J

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Since Cu2+ ions play a pivotal role in both ecosystems and human health, the development of a rapid and sensitive method for Cu2+ detection holds significant importance. Fluorescent mesoporous silica materials (FMSMs) have garnered considerable attention in the realm of chemical sensing, biosensing, and bioimaging due to their distinctive structure and easily functionalized surfaces. As a result, numerous Cu2+ sensors based on FMSMs have been devised and extensively applied in environmental and biological Cu2+ detection over the past few decades. This review centers on the recent advancements in the methodologies for preparing FMSMs, the mechanisms underlying sensing, and the applications of FMSMs‐based sensors for Cu2+ detection. Lastly, we present and elucidate pertinent perspectives concerning FMSMs‐based Cu2+ sensors.

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Engineered Conductive Metal–organic Frameworks for Electrochemical Detection of Urinary Biomarkers

Mohan,

Asif,

Pombeiro

2024

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The increasing prevalence of health concerns has sparked a demand for advanced health monitoring tools, which is a significant challenge for researchers. Analysis of biofluid samples and biomarker monitoring is vital for comprehensive health assessment. In this context, metal–organic frameworks (MOFs) have emerged as one of the leading materials for developing cutting‐edge artificial sensors. These unique MOFs have been developed from metallic and organic linkers and consist of tunable pores and dynamic surface areas, attracting various guest molecules to participate in developing advanced electrochemical devices. This study is a gateway to a world where MOF designs transcend mere inventions, morphing into electric marvels that revolutionize urine sample monitoring. From the inception and design to the fabrication of MOF sensors tailored for electrochemical applications, this study prides itself on elucidating the factors affecting MOF‐based electrical devices and sensors. Moreover, the focus is placed on conductivity, electrode properties, and recent state‐of‐the‐art urine sample analysis, highlighting the pivotal role biomarkers play in honing the resilience and performance of the sensors. Finally, this study is specific to electrochemical sensors used for urine analysis. It will attract researchers to develop new portable tools for health monitoring by analyzing urine samples.

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Inorganic–organic hybrid materials to detect urinary biomarkers: recent progress and future prospects

Abstract: Inorganic-organic hybrid materials have received extensive attention due to their excellent properties of recombination. In the framework of biological and chemical sensing, the utilization of hybrid materials for disease monitoring...

Cited by 5 publications

References 166 publications

Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device

Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device

Fluorogen‐Functionalized Mesoporous Silica Hybrid Sensing Materials: Applications in Cu²⁺ Detection

Engineered Conductive Metal–organic Frameworks for Electrochemical Detection of Urinary Biomarkers

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Inorganic–organic hybrid materials to detect urinary biomarkers: recent progress and future prospects

Abstract: Inorganic-organic hybrid materials have received extensive attention due to their excellent properties of recombination. In the framework of biological and chemical sensing, the utilization of hybrid materials for disease monitoring...

Cited by 5 publications

References 166 publications

Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device

Hydrogel-Film-Fabricated Fluorescent Biosensors with Aggregation-Induced Emission for Albumin Detection through the Real-Time Modulation of a Vortex Fluidic Device

Fluorogen‐Functionalized Mesoporous Silica Hybrid Sensing Materials: Applications in Cu2+ Detection

Engineered Conductive Metal–organic Frameworks for Electrochemical Detection of Urinary Biomarkers

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Fluorogen‐Functionalized Mesoporous Silica Hybrid Sensing Materials: Applications in Cu²⁺ Detection