2024
DOI: 10.1002/advs.202306062
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Inorganic Phosphate as “Bioenergetic Messenger” Triggers M2‐Type Macrophage Polarization

Xiaoqing Sun,
Zhiyu Li,
Xiang Wang
et al.

Abstract: The effects of calcium phosphate (CaP) materials on macrophage polarization state vary with their physicochemical properties. The study aims to elucidate the impact of phosphate ion‐mediated energy metabolism on M2 macrophage polarization and the corresponding regulatory mechanism. The phosphate ions released from CaP ceramic as bioenergetic factor is identified; its concentration is closely associated with the polarized state. After being taken up by the sodium‐dependent phosphate transporter 1, extracellular… Show more

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Cited by 2 publications
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“…Additionally, intracellular ATP is secreted into the extracellular environment and metabolized to adenosine, serving as a signaling molecule to promote M2 macrophage polarization via the A2b adenosine receptor. 45…”
Section: Resultsmentioning
confidence: 99%
“…Additionally, intracellular ATP is secreted into the extracellular environment and metabolized to adenosine, serving as a signaling molecule to promote M2 macrophage polarization via the A2b adenosine receptor. 45…”
Section: Resultsmentioning
confidence: 99%