Inositol hexanicotinate self-micelle solid dispersion is an efficient drug delivery system in the mouse model of non-alcoholic fatty liver disease

Zheng, Lei; Sun, Chen; Zhu, Xingyi; Xu, Wenhao; Yu, Jian; Zhang, Qihong; Душкин, А. В.; Su, Weike

doi:10.1016/j.ijpharm.2021.120576

Cited by 9 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that drugs with poor water solubility can form solid dispersions with GA, further improving the solubility and bioavailability. Zheng et al applied mechanical ball milling technology to prepare inositol hexanicotinic acid self-micelle solid dispersions with glycyrrhetinic acid and arabic gum, enhancing the solubility, amorphous stability, and bioavailability of IHN . Lu et al established a solid dispersion of candesartan cilexetil and glycyrrhizic acid through hydrogen bonding, which greatly enhanced its water solubility and stability .…”

Section: Introductionmentioning

confidence: 99%

“…Zheng et al applied mechanical ball milling technology to prepare inositol hexanicotinic acid self-micelle solid dispersions with glycyrrhetinic acid and arabic gum, enhancing the solubility, amorphous stability, and bioavailability of IHN. 13 Lu et al established a solid dispersion of candesartan cilexetil and glycyrrhizic acid through hydrogen bonding, which greatly enhanced its water solubility and stability. 14 Furthermore, mesoporous silica nanoparticles (MSN, Figure 1b) are widely utilized in insoluble drug delivery systems due to their affordability, ease of modification, and large specific surface area.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization and Dissolution Mechanism of Low-Molecular-Weight Organic Acids or Inorganic Mesoporous Particle-Based Piperine Amorphous Solid Dispersions

Li,

Zhang,

et al. 2024

Langmuir

View full text Add to dashboard Cite

The objective of the current study is to prepare amorphous solid dispersions (ASDs) containing piperine (PIP) by utilizing organic acid glycyrrhizic acid (GA) and inorganic disordered mesoporous silica 244FP (MSN/244FP) as carriers and to investigate their dissolution mechanism. The physicochemical properties of ASDs were characterized with scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). Fourier transform infrared spectroscopy (FTIR) and one-dimensional proton nuclear magnetic resonance ( 1 H NMR) studies collectively proved that strong hydrogen-bonding interactions formed between PIP and the carriers in ASDs. Additionally, molecular dynamic (MD) simulation was conducted to simulate and predict the physical stability and dissolution mechanisms of the ASDs. Interestingly, it revealed a significant increase in the dissolution of amorphous PIP in ASDs in in vitro dissolution studies. Rapid dissolution of GA in pH 6.8 medium resulted in the immediate release of PIP drugs into a supersaturated state, acting as a dissolution-control mechanism. This exhibited a high degree of fitting with the pseudo-second-order dynamic model, with an R 2 value of 0.9996. Conversely, the silanol groups on the outer surface of the MSN and its porous nanostructures enabled PIP to display a unique two-step drug release curve, indicating a diffusioncontrolled mechanism. This curve conformed to the Ritger−Peppas model, with an R 2 > 0.9. The results obtained provide a clear evidence of the proposed transition of dissolution mechanism within the same ASD system, induced by changes in the properties of carriers in a solution medium of varying pH levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Characterization and Dissolution Mechanism of Low-Molecular-Weight Organic Acids or Inorganic Mesoporous Particle-Based Piperine Amorphous Solid Dispersions

Li,

Zhang,

et al. 2024

Langmuir

View full text Add to dashboard Cite

show abstract

“…[ 9 ]. However, solvent evaporation will leave the product with residual organic solvent and high temperature of the melting process may lead to decomposition or degradation of the drug [ 10 ]. Recently, a novel strategy, mechanochemistry preparing SD widely applied as drug solubilization, has the remarkable characteristics of changing particle structure and enhancing the activity of drug by simple operation with high efficiency and less solvent residual [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of DNC Solid Dispersion by a Mechanochemical Method with Glycyrrhizic Acid and Polyvinylpyrrolidone to Enhance Bioavailability and Activity

Lü

Wei

et al. 2022

Polymers

Self Cite

View full text Add to dashboard Cite

To exploit aqueous-soluble formulation and improve the anticoccidial activity of 4,4′-dinitrocarbanilide (DNC, active component of nicarbazin), this paper prepared DNC/GA/PVP K30 solid dispersion (SD) with glycyrrhizic acid (GA) and polyvinylpyrrolidone (PVP) K30 by a mechanical ball milling method without using any organic solvent. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy were used for the solid state characterization. High performance liquid chromatography, critical micelle concentration, particle characterization, and transmission electron microscopy were used to evaluate the behavior in aqueous solution. In addition, the oral bioavailability, tissue distribution, and anticoccidial activity of DNC/GA/PVP K30 SD were investigated as well. Compared with free drug, the novel formulation not only improved the solubility and dissolution rate of DNC, but also inhibited the fecal output of oocysts and enhanced the therapeutic effect of coccidiosis. According to the experiment results, the DNC/GA/PVP K30 SD increased 4.64-fold in oral bioavailability and dramatically enhanced the concentration in liver which provided a basis for further research in schistosomiasis. In summary, our findings suggested that DNC/GA/PVP K30 SD may have promising applications in the treatment of coccidiosis.

show abstract

Self-nanomicellizing solid dispersion: A promising platform for oral drug delivery

Chen,

Yan,

Sun

et al. 2024

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Inositol hexanicotinate self-micelle solid dispersion is an efficient drug delivery system in the mouse model of non-alcoholic fatty liver disease

Cited by 9 publications

References 45 publications

Characterization and Dissolution Mechanism of Low-Molecular-Weight Organic Acids or Inorganic Mesoporous Particle-Based Piperine Amorphous Solid Dispersions

Characterization and Dissolution Mechanism of Low-Molecular-Weight Organic Acids or Inorganic Mesoporous Particle-Based Piperine Amorphous Solid Dispersions

Preparation of DNC Solid Dispersion by a Mechanochemical Method with Glycyrrhizic Acid and Polyvinylpyrrolidone to Enhance Bioavailability and Activity

Self-nanomicellizing solid dispersion: A promising platform for oral drug delivery

Contact Info

Product

Resources

About