1998
DOI: 10.1002/(sici)1098-1136(199812)24:4<398::aid-glia5>3.3.co;2-i
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Inositol‐trisphosphate‐dependent intercellular calcium signaling in and between astrocytes and endothelial cells

Abstract: Interactions between astrocytes and endothelial cells are believed to play an important role in the control of blood-brain barrier permeability and transport. Astrocytes and endothelial cells respond to a variety of stimuli with an increase of intracellular free calcium ([Ca2+]i) that is propagated to adjacent cells as an intercellular Ca2+ wave. We hypothesized that intercellular Ca2+ signaling also occurs between astrocytes and endothelial cells, and we investigated this possibility in co-cultures of primary… Show more

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Cited by 38 publications
(61 citation statements)
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“…Mammalian gap junction channels permit the direct cell-to-cell spread of molecules less than approximately one kDa and thus facilitate cellular homeostasis. Many second messengers and other signal molecules that are involved in cell growth control and differentiation pass through gap junction channels, including cAMP, calcium ion, ATP, and inositol-triphosphate [Goldberg et al, 1998;Kam et al, 1998;Lawrence et al, 1978;Leybaert et al, 1998;Saez et al, 1989]. Changes in the intracellular concentrations of second messengers, and other small signal molecules, are critical for cell cycle progression and signal transduction [Pastan et al, 1975;Whitfield et al, 1979].…”
Section: Discussionmentioning
confidence: 99%
“…Mammalian gap junction channels permit the direct cell-to-cell spread of molecules less than approximately one kDa and thus facilitate cellular homeostasis. Many second messengers and other signal molecules that are involved in cell growth control and differentiation pass through gap junction channels, including cAMP, calcium ion, ATP, and inositol-triphosphate [Goldberg et al, 1998;Kam et al, 1998;Lawrence et al, 1978;Leybaert et al, 1998;Saez et al, 1989]. Changes in the intracellular concentrations of second messengers, and other small signal molecules, are critical for cell cycle progression and signal transduction [Pastan et al, 1975;Whitfield et al, 1979].…”
Section: Discussionmentioning
confidence: 99%
“…Although direct signaling through neuron-glial or endothelial-glial GJCs has been reported in cell culture systems [106,107,[210][211][212], signaling at these contact points is suggested to be mainly governed by paracrine mechanisms [193,213], especially at the site of the vascular wall where the basement membrane impairs formation of astrocyte-endothelial GJCs in vivo [193]. More specifically, astrocytes are equipped with a large repertoire of neurotransmitter receptors [214], allowing them to sense neuronal and vascular activity.…”
Section: Glial Signalingmentioning
confidence: 99%
“…3) [211,237]. Cx-based intercellular communication in the astrocytic network can thus actively participate in signaling processes via the propagation of ICWs [14].…”
Section: Glial Signalingmentioning
confidence: 99%
“…Studies performed in the early 1990s involved the application of neurotransmitters and mechanical stimulation to activate astrocytes [11]. Later, electrical stimulation [12,13] and uncaging [14,15] techniques were developed. However, several problems are involved in these methods, including their complexity, the necessity of physical contact, the requirement of additional chemicals, and difficulties in precisely targeting them.…”
mentioning
confidence: 99%
“…Scale bar, 50 μm; (b) time serials of fluorescence images after photostimulation. Scale bar, 50 μm; (c) relative fluorescence changes in astrocytes ("As", 1-6) and neurons ("Neu",7,8,[9][10][11][12][13][14][15][16][17] labeled in (a). Arrows indicate the onset of photostimulation.…”
mentioning
confidence: 99%