Inositol-trisphosphate-dependent intercellular calcium signaling in and between astrocytes and endothelial cells

Leybaert, Luc; Paemeleire, Koen; Strahonja, Andreja; Sanderson, Michael J.

doi:10.1002/(sici)1098-1136(199812)24:4<398::aid-glia5>3.0.co;2-r

Cited by 130 publications

(53 citation statements)

References 40 publications

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“…Connexin-mediated intercellular Ca 2ϩ signaling can occur by movement of second messengers such as IP 3 and/or Ca 2ϩ through GJCs (1,(12)(13)(14)(15)(16)(17)(18)(19)(20) or by a process that involves release of ATP through HCs (paracrine pathway) (1,4,8,17,21). In the latter, ATP release through HCs increases Ca 2ϩ influx and intracellular [Ca 2ϩ ] in response to activation of purinergic receptors in neighboring cells.…”

Section: ؉ Influx Into Cells Under Conditions Such As Ischemiamentioning

confidence: 99%

“…In the latter, ATP release through HCs increases Ca 2ϩ influx and intracellular [Ca 2ϩ ] in response to activation of purinergic receptors in neighboring cells. There are studies that support roles of IP 3 and/or Ca 2ϩ permeation through GJCs (12)(13)(14)(15)(16)(17)(18)(19)(20), as well as a major role of HCs in the paracrine pathway (4,8,17,21). However, unambiguous identification of the pathways and mediators associated with an effect in cells is possible but often difficult.…”

Section: ؉ Influx Into Cells Under Conditions Such As Ischemiamentioning

confidence: 99%

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Permeation of Calcium through Purified Connexin 26 Hemichannels

Fiori

Figueroa

Zoghbi

et al. 2012

Journal of Biological Chemistry

105

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Section: ؉ Influx Into Cells Under Conditions Such As Ischemiamentioning

confidence: 99%

Section: ؉ Influx Into Cells Under Conditions Such As Ischemiamentioning

confidence: 99%

Permeation of Calcium through Purified Connexin 26 Hemichannels

Fiori

Figueroa

Zoghbi

et al. 2012

Journal of Biological Chemistry

105

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“…However, junctional Ca flux may also be involved. In some cases, it is clear that regenerative Ca signaling is mediated by IP3 flux and that the contribution of junctional Ca flux to this process is minor (Venance et al, 1997;Leybaert et al, 1998). In other cases it appears that junctional Ca flux is a major factor (Sáez et al, 1989;Boitano et al, 1992;Christ et al, 1992).…”

Section: Junctional Channelsmentioning

confidence: 99%

Connexin channel permeability to cytoplasmic molecules

Harris¹

2007

Progress in Biophysics and Molecular Biology

414

346

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Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The first observation of second messenger junctional permeability, made ∼30 years ago, sparked broad interest in gap junction channels as mediators of intercellular molecular signaling. Since then, much has been learned about the diversity of connexin channels with regard to isoform diversity, tissue and developmental distribution, modes of channel regulation, assembly and expression, biochemical modification and permeability, all of which appear to be dynamically regulated. This information has expanded the potential roles of connexin channels in development, physiology and disease, and made their elucidation much more complex -30 years ago such an orchestra of junctional dynamics was unanticipated. Only recently, however, have investigators been able to directly address, in this more complex framework, the key issue: What specific biological molecules, second messengers and others, are able to permeate the various types of connexin channels, and how well? An important related issue, given the ever-growing list of connexin-related pathologies, is how these permeabilities are altered by disease-causing connexin mutations. Together, many studies show that a variety of cytoplasmic molecules can permeate the different types of connexin channels. A few studies reveal differences in permeation by different molecules through a particular type of connexin channel, and differences in permeation by a particular molecule through different types of connexin channels. This article describes and evaluates the various methods used to obtain these data, presents an annotated compilation of the results, and discusses the findings in the context of what can be inferred about mechanism of selectivity and potential relevance to signaling. The data strongly suggest that highly specific interactions take place between connexin pores and specific biological molecular permeants, and that those interactions determine which cytoplasmic molecules can permeate and how well. At this time, the nature of those interactions is unclear. One hopes that with more detailed permeability and structural information, the specific molecular mechanisms of the selectivity can be elucidated.

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“…Astrocyte Ca 2ϩ waves may occur spontaneously or may be evoked by a variety of stimuli including mechanical stimulation, electrical stimulation, or neurotransmitters (Charles, 1998). In addition to being a pathway for communication among astrocytes, Ca 2ϩ waves have been shown to be a pathway for bidirectional signaling between astrocytes and multiple other cell types, including neurons (Araque et al, 1998;Kang et al, 1998;Parri et al, 2001), microglia (Schipke et al, 2002), and vascular endothelial cells (Leybaert et al, 1998;Paemeleire and Leybaert, 2000).…”

Section: Introductionmentioning

confidence: 99%

Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium

Stout

Charles

2003

Glia

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The extracellular concentrations of Ca 2ϩ and Mg 2ϩ are well known to play important roles in the function of the central nervous system. We examined the effects of extracellular Ca 2ϩ and Mg 2ϩ on ATP release and intercellular signaling in astrocytes. [Ca 2ϩ ] o -activated whole cell currents consistent with currents through connexin hemichannels. These currents were inhibited by extracellular Mg 2ϩ . We conclude that extracellular divalent cations modulate intercellular Ca 2ϩ signaling in astrocytes by modulating the release of ATP, possibly via connexin hemichannels.

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Inositol-trisphosphate-dependent intercellular calcium signaling in and between astrocytes and endothelial cells

Cited by 130 publications

References 40 publications

Permeation of Calcium through Purified Connexin 26 Hemichannels

Permeation of Calcium through Purified Connexin 26 Hemichannels

Connexin channel permeability to cytoplasmic molecules

Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium

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