Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Vitacolonna, Ester; Palmisano, Luisa; Stuppia, Liborio; Franzago, Marica

doi:10.3390/nu14081543

Cited by 8 publications

(3 citation statements)

References 81 publications

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“…[27,28] Dietary intervention combined with insulin aspart treatment is effective for controlling the blood sugar of patients with GDM and optimizing the treatment outcomes. [29] In this study, the overall effectiveness of treatment was significantly higher in the dietary intervention group than in the control group, which is consistent with previous research indicating that dietary intervention combined with insulin aspart is more effective than insulin aspart alone. The analysis suggests that insulin aspart plays a role in blood sugar regulation, and the dietary intervention through a formulated meal plan also contributes to blood sugar control.…”

Section: Discussionsupporting

confidence: 91%

Effects of dietary intervention combined with insulin aspart on serum nesfatin-1 and CTRP12 levels and pregnancy outcomes in pregnant women with gestational diabetes mellitus

Yang,

Guo,

Guo

et al. 2023

Medicine

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To analyze the effects of dietary intervention combined with insulin aspart on the serum levels of nesfatin-1, C1q/TNF related protein-12 (CTRP12), and pregnancy outcomes in pregnant women with gestational diabetes mellitus (GDM). In this retrospective cohort study, 513 women with GDM admitted to Tangshan Central Hospital (Tangshan, China) between January 2019 and December 2022 were selected and divided into an observation group (dietary intervention combined with insulin aspart therapy; n = 284) and a control group (insulin aspart therapy, n = 229). The general characteristics, clinical outcomes, serum nesfatin-1 and CTRP12 levels, 2-hour postprandial blood glucose levels, pregnancy outcomes, and perinatal outcomes of the 2 groups were compared. After treatment, the total effective rate in the observation group was significantly higher than that of the control group (97.54% vs 86.03%, respectively; P < .001). Compared with the pretreatment levels, nesfatin-1 and CTRP12 levels were decreased in both groups; nesfatin-1 and CTRP12 levels in the observation group were significantly higher than those in the control group. After treatment, the preprandial and 2-hour postprandial blood glucose levels in the observation group were significantly lower than those in the control group. Compared with the control group, the observation group had significantly fewer cesarean sections, and a significantly lower incidence of postpartum hemorrhage, premature rupture of membranes, and other adverse pregnancy outcomes. After treatment, the risks of preterm birth, macrosomia, fetal distress, neonatal asphyxia, neonatal hypoglycemia, and other adverse perinatal outcomes were significantly lower in the observation group than in the control group. In pregnant women with GDM, dietary intervention combined with insulin aspart can improve clinical outcomes; reduce nesfatin-1, CTRP12, and blood glucose levels; and reduce the incidence of adverse pregnancy outcomes.

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Section: Discussionsupporting

confidence: 91%

Effects of dietary intervention combined with insulin aspart on serum nesfatin-1 and CTRP12 levels and pregnancy outcomes in pregnant women with gestational diabetes mellitus

Yang,

Guo,

Guo

et al. 2023

Medicine

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“…Myo-inositol is one of the predominant forms under which inositols can be found in nature and that have shown to have therapeutic effects in human health; the dysregulation of myo-inositol metabolism is associated with insulin resistance and long-term microvascular complication of diabetes [ 105 ]. Because of reduced intake, increased catabolism and excretion, decreased biosynthesis and inhibition of intestinal absorption of myo-inositol, the need of this nutrient is increased during pregnancy [ 106 , 107 ].…”

Section: Gdm and Gtd: Common Risk Factors?mentioning

confidence: 99%

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Pinto

Croce

Carlier

et al. 2023

J Endocrinol Invest

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Purpose Gestational diabetes mellitus (GDM) and thyroid dysfunction during gestation (GTD) are the two most prevalent endocrinopathies during pregnancy. The aim of the present review is to provide an overview of the peculiar aspects of GDM and GTD, to highlight the potential interactions and clinical consequences of these two frequent clinical conditions. Methods A literature review regarding GDM and GTD was carried out with particular interest on meta-analyses and human studies dealing with the (i) shared risk factors between GDM and GTD, (ii) the epidemiological link between GTD and GDM, (iii) physiopathologic link between GTD and GDM, (iv) clinical consequences of GDM and GTD, and (v) post-partum implications of GDM and GTD. Results The association between GDM and GTD is common and may be explained by the insulin-resistance state due to maternal GTD, to alterations in the placentation process or to the many shared risk factors. Discrepant results of epidemiologic studies can be explained, at least in part, by the changes in diagnostic criteria and screening strategies throughout the years for both conditions. GDM and GTD impact pregnancy outcome and have post-partum long-term consequences, but more studies are needed to prove an additional adverse effect. Conclusions Based on the epidemiological and physio-pathological link between GDM and GTD, it could be suggested that a diagnosis of GTD could lead to screen GDM and the other way round.

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“…[5] Since China's universal "three-child policy" was announced in May 2021, the number of high-risk pregnant women with advanced maternal age has increased dramatically, and GDM prevalence is expected to rise further in the coming years. [6,7] Therefore, the need to find a means to lower the risk of GDM is important.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Fiber on the Risk of Gestational Diabetes Mellitus in Advanced Maternal Age Women: Study Protocol for a Randomized Controlled Trial

Zhang

Sheng

Chen

et al. 2022

Molecular Nutrition Food Res

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Scope To investigate whether dietary fiber supplementation may reduce the risk of gestational diabetes mellitus (GDM) in advanced maternal age Chinese women (≥35 years). Secondary outcomes include glucose metabolism, diet change, weight gain, and maternal and neonatal outcomes. Methods and results In a randomized controlled trial, a dietary fiber group (19.56 g day−1) or control group (standard prenatal care) was conducted from 20 to 24+6 gestational weeks in advanced maternal age women. Dietary intakes were assessed using a validated 39‐item Food Frequency Questionnaire (FFQ). GDM was diagnosed by a 75 g oral glucose tolerance test (OGTT) at 25–28 weeks. After intervention, the incidence of GDM was not significantly different between groups (21.6% vs 12.9%, p = 0.165). The mean increased in carbohydrate intake in the dietary fiber group is significantly lower than in the control group (−0.94 ± 92.12 g vs 32.27 ± 91.81 g, p = 0.032). In addition, the glucose tolerance, weight gain between 20 and 25 weeks, and preterm birth in the intervention group have improved compared to the control group. Conclusion Supplementation with dietary fiber during pregnancy among advanced maternal age Chinese women do not lower the incidence of GDM, but improve glucose metabolism, gestational weight gain, and preterm birth.

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Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Cited by 8 publications

References 81 publications

Effects of dietary intervention combined with insulin aspart on serum nesfatin-1 and CTRP12 levels and pregnancy outcomes in pregnant women with gestational diabetes mellitus

Effects of dietary intervention combined with insulin aspart on serum nesfatin-1 and CTRP12 levels and pregnancy outcomes in pregnant women with gestational diabetes mellitus

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Effects of Dietary Fiber on the Risk of Gestational Diabetes Mellitus in Advanced Maternal Age Women: Study Protocol for a Randomized Controlled Trial

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