Inotropic and cardioprotective effects of Daucus carota Linn. on isoproterenol-induced myocardial infarction

Muralidharan, P.; Balamurugan, G.; Kumar, Pavan

doi:10.3329/bjp.v3i2.849

Cited by 32 publications

(21 citation statements)

References 13 publications

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“…Cardioprotection was assessed by estimating serum aspartate transaminase, alanine transaminase, lipid peroxidase, and lactate dehydrogenase levels and cardiac total protein, lipid peroxidase, and lactate dehydrogenase. The levels altered by isoproterenol were restored significantly by the administration of the extract [134]. High-carbohydrate, high-fat diet-fed rats developed hypertension, cardiac fibrosis, increased cardiac stiffness, endothelial dysfunction, impaired glucose tolerance, increased abdominal fat deposition, altered plasma lipid profile, liver fibrosis and increased plasma liver enzymes together with increased plasma markers of oxidative stress and inflammation as well as increased inflammatory cell infiltration.…”

Section: Cardiovascular Effectsmentioning

confidence: 95%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, chlorogenic acid, flavonoids, phenols, essential oil, terpenoid and coumarin. The nutritional analysis of carrot juice showed that the juice contained: protein 1.067 ± 0.058%, crude fat 0.367 ± 0.089%, crude fibre 1.167 ± 0.153%, carbohydrates 6.100 ± 0.346%, many vitamins and minerals. The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastro-protective, nephro-protective, hepato-protective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. The current review highlights the chemical constituents, nutritional and pharmacological effects of Daucus carota.

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Section: Cardiovascular Effectsmentioning

confidence: 95%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

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“…Seeds of carrot caused to decrease in cholesterol (Da Silva Dias, 2014). Muralidharan et al, (2008) observed that in carrot seed extract fed rats; levels of plasma lactate dehydrogenase, alanine transaminase, and aspartate transaminase were significantly declined. Moreover, Singh et al (2010) observed that rats fed with carrot seeds showed a significant increase in antioxidant enzyme levels such as glutathione peroxidase, superoxide dismutase and, catalase as compared with the control group of rats.…”

Section: Introductionmentioning

confidence: 99%

Physiological Response, Semen Quality and Blood Biochemical Parameters of Rabbit Bucks Supplemented With Phytogenic Components During Summer Season of Egypt

Abdel-Azeem

Fayed

Azoz

2018

Egyptian Journal of Nutrition and Feeds

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eventy-two mature New Zealand White (NZW) rabbit's bucks were randomly and equally divided into eight groups each of nine bucks to evaluate the impact each of rocket seeds (RS), carrot seeds (CS), or bay laurel leaves (BLL) and their mixtures on semen quality, biochemical components and the physiological response of NZW rabbits bucks during hot summer conditions. The study started in June and lasted for 8 weeks. Eight experimental diets were formulated such that diet (D1) free additives as a control group. Diets 2, 3 and 4 contained 1.0% RS, 1.0% CS and 1.0% BLL, respectively. Diet 5, 6 and 7 contained a mix of 0.5% RS+0.5% CS, 0.5% CS+0.5% BLL and 0.5% RS+0.5% BLL, respectively, while diet 8 contained 0.33% RS+0.33% CS+0.33% BLL. Insignificant effect on buck's body weight, however, feed intake was significantly increased as compared to bucks group given the control diet. Supplementation with RS, CS, BLL, and their mixtures caused significant improvement in ejaculate volume, individual motility, total motile sperm, sperm concentration, live sperm%, total functional sperm fraction, total sperm output, and decreased abnormal sperm%. Seminal plasma initial fructose and globulin increased significantly with RS, CS, BLL, and their mixtures treatments. Seminal plasma alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) appeared reduction significantly with the RS, CS, BLL and their mixtures treatments. Seminal plasma total antioxidant capacity (TAC) increased, while, malondialdehyde (MDA) levels significantly decreased in all supplemented groups compared with the control bucks' value. Most of the supplemented groups showed a significant decrease in blood plasma glucose, cholesterol, triglycerides, and total lipids, low-density lipoproteins, AST and ALT as compared to the control group. However, blood plasma total protein and albumin were increased in comparison with the control group. Blood plasma TAC significantly increased due to the addition of RS, CS, BLL, and their mixtures as compared to the control group, but MDA levels decreased.

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“…The formation of free radicals as well as lipid peroxides, which causes to damage the myocardial muscles [16,17]. The myocardium contains the LDH and transaminases as enzymatic markers of MI, which were releases from damaged tissues into extracellular fluid [18]. The results of phytochemical screening of EEIT contain the flavonoids, saponins, tannins, and phenols.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Indigofera Tinctoria Linn. Against Myocardial Infarction-Induced Rats

Puligilla¹,

Priyanka²

2018

Asian J Pharm Clin Res

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Objective: The aim and objective of the present study are to study the protective effects of ethanolic extract of Indica tinctoria (EEIT) in isoproterenolinduced acute myocardial infarction (AMI) in rats. Methods:The effect of two doses of isoproterenol (5 mg/kg and 8.5 mg/kg body weight) changes in aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and total protein (TP) and lipid hydroperoxides, superoxide dismutase (SOD), and glutathione (GSH) in blood serum and heart homogenate, for the two consecutive days (29 and 30), were administered subcutaneously in rats in pre-treatment with EEIT for the 28-day study.Results: There was increased the AST, ALT, LDH, CPK, and lipid peroxides levels and decreased the TP, SOD, GSH with Isoproterenol-induced group. Pre-treatment for 28 days with Indigofera tinctoria significantly (p<0.05) increased antioxidants (SOD , GSH) , TP levels and decreased the cardiotoxic agents significantly (p<0.05) such as LPO, AST, ALT, LDH, and CPK levels in treatment groups. Conclusion:I. tinctoria contains beneficial bioactive photochemicals that have been protective effective against isoproterenol-induced AMI in rats.

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Inotropic and cardioprotective effects of Daucus carota Linn. on isoproterenol-induced myocardial infarction

Cited by 32 publications

References 13 publications

Nutritional and therapeutic importance of Daucus carota- A review

Nutritional and therapeutic importance of Daucus carota- A review

Physiological Response, Semen Quality and Blood Biochemical Parameters of Rabbit Bucks Supplemented With Phytogenic Components During Summer Season of Egypt

Cardioprotective Effect of Indigofera Tinctoria Linn. Against Myocardial Infarction-Induced Rats

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