Inotropic Therapy of Heart Failure. Editorial comments on: Vasodilation and mechanoenergetic inefficiency dominates the effect of the "Ca 2+ sensitizer" MCI-154 in intact pigs

In the last few years, the pyridazine derivatives have been found to exhibit a wide range of pharmacological activities. A large number of research articles and patents described them, and several drugs based on its nucleus have come into light. Pyridazinone, a derivative of pyridazine, was initially exploited in search of cardiovascular drugs and for its use in agrochemicals, but later on this nucleus was found to be associated with plethora of activities. In this article, we have reviewed the influence of structural changes on the pharmacodynamic profile of the pyridazinone moiety.

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Calcium Sensitizers, a New Class of Inodilators

Kwak

2005

International Anesthesiology Clinics

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Inotropic Therapy of Heart Failure. Editorial comments on: Vasodilation and mechanoenergetic inefficiency dominates the effect of the "Ca 2+ sensitizer" MCI-154 in intact pigs

Cited by 3 publications

References 47 publications

The effect of pyridazine compounds on the cardiovascular system

The effect of pyridazine compounds on the cardiovascular system

Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

Calcium Sensitizers, a New Class of Inodilators

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