Inpatient Burden and Mortality of Methanol Intoxication in the United States

Kaewput, Wisit; Petnak, Tananchai; Chewcharat, Api; Boonpheng, Boonphiphop; Vallabhajosyula, Saraschandra; Cheungpasitporn, Wisit

doi:10.1016/j.amjms.2020.08.014

Cited by 19 publications

(25 citation statements)

References 23 publications

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“…There was no correlation between ethyl alcohol and fomepizole used as antidotes in terms of mortality (p=0.549). This situation is similar to previous studies (2,10,17). Bicarbonate treatment was applied to 78% (n=46) of the patients, and hemodialysis was applied to 76% (n=45) of them.…”

Section: Discussionsupporting

confidence: 89%

“…In our study, the mortality rate was determined as 25.4% (n=15). This rate is similar to the studies conducted in Turkey (7,14), but it is considerably higher than the studies conducted abroad (10,11,15). Such a high mortality rate may be related to the number of patients who need hemodialysis and mechanical ventilation.…”

Section: Discussionsupporting

confidence: 86%

“…other was found to be very close to the normal range and is not considered clinically significant. Although some studies have reported a relationship between high sodium value and mortality (8,9,10,11), according to the logistic regression analysis performed in our study, sodium alone was not an independent factor. The emergence of neurological symptoms and the decrease in GCS are interrelated and have been shown to increase mortality (12,13).…”

Section: Discussioncontrasting

confidence: 79%

“…Bicarbonate treatment was applied to 78% (n=46) of the patients, and hemodialysis was applied to 76% (n=45) of them. In a study conducted in our country, it was reported that 87% of the patients were treated with bicarbonate and 84% of them were treated with hemodialysis (10,11). In the USA, the rate of patients undergoing hemodialysis is about half of that in our country (10,11).…”

Section: Discussionmentioning

confidence: 99%

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Methanol poisoning in the emergency department: a retrospective study

Yurtsever

ARIKAN

Acar

et al. 2022

Journal of Health Sciences and Medicine

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Aim: Massive methanol poisonings have occurred in the past decades, resulting in a large number of deaths. In this study, our aim is to retrospectively analyze methanol poisoning cases admitted to the emergency department between 2019-2021, to evaluate their demographic characteristics, causes of poisoning, clinical and laboratory findings, treatments applied and mortality, and to contribute to the poisoning data of our country. Material and Method: The cases of methanol poisoning who applied to the emergency department in a 3-year period were analyzed retrospectively. Medical files of patients aged 18 years and older were reviewed. Patients diagnosed with 'methanol poisoning' as a result of the examination were included in the study. Results: A total of 59 patients were included in the study. 88% (n=52) of the patients with a mean age of 53±10 were male. The presence of neurological symptoms and GCS were associated with mortality among the symptoms of patients presenting to the emergency department (p=0.017, p

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Methanol poisoning in the emergency department: a retrospective study

Yurtsever

ARIKAN

Acar

et al. 2022

Journal of Health Sciences and Medicine

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“…Methanol poisoning is a serious life-threatening condition with a mortality rate ranging from 18 to 44% (Noor et al 2020 ). Annually in the US, about 5.000 cases are diagnosed with an incidence of 6.4 cases per 1 million hospitalizations, and with the mean age of patients being 38 ± 18 years with a distinct predominance of the male sex (70 vs. 30%) (Kaewput et al 2021 ; Kraut 2016 ). According to statistical data, the prevalence of methanol intoxication is most common in developing countries and Southeast Asia, mainly among the lower economic and social strata (Abrishami et al 2011 ; Noor et al 2020 ), and is usually associated with accidental oral consumption due to similar physical properties to ethanol, especially in countries with alcohol prohibition, where a higher percentage of methanol poisonings is observed secondary to the oral consumption of contaminated alcohol from illegal domestic production (Khalili et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Methanol-induced optic neuropathy: a still-present problem

2022

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Methanol-induced optic neuropathy (Me-ION) is a serious condition that may result in long-term or irreversible visual impairment or even blindness secondary to damage and loss of function of the optic nerve and retina. Me-ION shows a tendency to occur as mass poisonings around the world with a clear predilection for poor societies in developing countries. The main mechanism underlying the molecular basis of Me-ION is the inhibition of the mitochondrial oxidative phosphorylation process through the binding of the toxic metabolite of methanol—formic acid—with the key enzyme of this process—cytochrome c oxidase. However, other mechanisms, including damage to the eye tissues by oxidative stress causing the intensification of the oxidative peroxidation process with the formation of cytotoxic compounds, as well as an increase in the synthesis of pro-inflammatory cytokines and influence on the expression of key proteins responsible for maintaining cell homeostasis, also play an important role in the pathogenesis of Me-ION. Histopathological changes in the eye tissues are mainly manifested as the degeneration of axons and glial cells of the optic nerve, often with accompanying damage of the retina that may involve all its layers. Despite the development of therapeutic approaches, persistent visual sequelae are seen in 30–40% of survivors. Thus, Me-ION continues to be an important problem for healthcare systems worldwide.

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Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes

Esmaeilian,

Teimouri,

Hooshmandi

et al. 2023

Health Science Reports

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ObjectiveTo evaluate the frequency and significance of brain imaging findings in methanol poisoning patients and to propose a criterion for prioritizing brain imaging.MethodsWe retrospectively reviewed the data of 306 patients (286 men and 34 women, mean age 32.10 ± 9.9 years) with confirmed methanol poisoning who were admitted to two hospitals in Iran during the COVID‐19 pandemic. We analyzed their demographic, clinical, laboratory, and brain imaging data.ResultsThe main brain computed tomography (CT) scan findings were hypodensity in the putamen (11.1%), cerebellar nuclei (8.2%), diffuse cerebral edema (7.5%), and intracranial hemorrhage (ICH; 1.6%). These findings were associated with blood pH, Glasgow Coma Scale (GCS), renal failure, bicarbonate, oxygen, carbon dioxide, potassium, and glucose levels (p < 0.05). Poor prognosis was related to blindness, opium addiction, chronic alcohol use, hyperglycemia, and abnormal CT scans (p < 0.001 for all). The most predictive brain imaging findings for poor prognosis were hypodensity in the cerebellar nuclei, diffuse cerebral edema, and ICH.ConclusionBrain imaging can provide valuable information for the diagnosis and management of methanol poisoning patients. We suggest that patients with severe acidosis, low GCS, low pH, low oxygen saturation, and high glucose levels should undergo brain CT scan as a priority.

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Inpatient Burden and Mortality of Methanol Intoxication in the United States

Cited by 19 publications

References 23 publications

Methanol poisoning in the emergency department: a retrospective study

Methanol poisoning in the emergency department: a retrospective study

Methanol-induced optic neuropathy: a still-present problem

Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes

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