Inpatient citrate-based hemodialysis in pediatric patients

Fajardo, Cecile; Sanchez, Cheryl P.; Cutler, Drew; Sahney, Shobha; Sheth, Rita D.

doi:10.1007/s00467-016-3403-8

Cited by 6 publications

(3 citation statements)

References 14 publications

(21 reference statements)

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“…Pediatric patients on chronic HD could also be a specific target population for citrate HD. A preliminary study in 18 pediatric patients treated for 9 months with a citrate‐based dialysate HD demonstrated excellent tolerance with low percentage of thrombotic episodes, resulting in catheter or circuit loss, with mild and asymptomatic hypocalcemia 130 …”

Section: Personalizationmentioning

confidence: 99%

“…Level II In chronic dialysis, combined use of heparin-grafted membrane and citrate dialysate could be applied to patients with different issues, such as heparin-induced thrombocytopenia or frequent clotting of the dialysis circuit.Pediatric patients on chronic HD could also be a specific target population for citrate HD. A preliminary study in 18 pediatric patients treated for 9 months with a citrate-based dialysate HD demonstrated excellent tolerance with low percentage of thrombotic episodes, resulting in catheter or circuit loss, with mild and asymptomatic hypocalcemia 130.…”

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confidence: 98%

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Updates on hemodialysis techniques with a common denominator: The personalization of the dialytic therapy

Monardo

Lacquaniti

Campo

et al. 2021

Seminars in Dialysis

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Morbidity and mortality marginally decreased over the last three decades in hemodialyzed (HD) patients, despite the introduction of multiple pharmacological and technological advancement. 1 Several randomized controlled studies failed to demonstrate the superiority of one procedure, schedule, or pharmacological interventions on survival and, consequently, weak level of recommendations has been revealed by best practice guidelines. [2][3][4][5] These negative results are closely related to the complexity of uremia, characterized by several metabolic disorders, as well as hyperparathyroidism, metabolic acidosis, Lcarnitine deficiency, and risk factors, influencing all-cause mortality. [6][7][8] General dialysis-dependent population is in fact elderly and affected by multiple co-morbid conditions, while hemodialysis (HD) represents just one component of the overall outcome-based risk profile. In particular, diabetes as well as obesity, due to their increasing incidence, are directly involved in kidney disease onset and progression. 9 Moreover, global patient heterogeneity, related to genetic, environmental, and demographic factors, needs to be evaluated as a risk factor for renal disease. Large-scale meta-analyses of genome-wide association studies have identified a number of loci significantly associated with systolic and/or diastolic blood pressure, apolipoproteins, or polymorphisms of vitamin D receptor, closely involved in the development of kidney disease. [10][11][12] Other obstacle to apply personalized dialysis is the lack of resources in the current sanitary systems, considering that, due to the combination of high costs and widespread need, renal replacement therapy is one of the most expensive treatments. 13,14 The actual costs of dialysis are not uniformly defined, with significant differences between highly resourced countries, where the most important item is the cost of nursing and medical care, and emerging countries, where the cost of dialysis supplies represents the most relevant item. 15 Moreover, ecologic implication is closely related with each HD session, analyzing water, energy, and waste

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Section: Personalizationmentioning

confidence: 99%

mentioning

confidence: 98%

Updates on hemodialysis techniques with a common denominator: The personalization of the dialytic therapy

Monardo

Lacquaniti

Campo

et al. 2021

Seminars in Dialysis

View full text Add to dashboard Cite

show abstract

“…A cohort of HD pediatric patients was treated with citrate-based dialysate, revealing a low percentage of thrombotic episodes, catheter or circuit loss, and mild and asymptomatic hypocalcemia [30].…”

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confidence: 99%