Inpatient Rehabilitation Performance of Patients With Paraneoplastic Cerebellar Degeneration

Fu, Jack B.; Raj, Vishwa S.; Asher, Arash; Lee, Jay; Guo, Ying; Konzen, Benedict; Bruera, Éduardo

doi:10.1016/j.apmr.2014.07.003

Cited by 17 publications

(12 citation statements)

References 10 publications

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“…Most patients become wheelchair bound although it has been reported that patients with PCD and anti-Hu or anti-Tr antibodies have less disability compared to those with PCD and anti-Yo antibodies [6]. A recent retrospective study of a small series of PCD patients found that some had meaningful functional improvemnt after intensive inpatient rehabilitation [31*]. …”

Section: Paraneoplastic Cerebellar Degenerationmentioning

confidence: 99%

Update on neurological paraneoplastic syndromes

Höftberger

Rosenfeld

Dalmau

2015

Current Opinion in Oncology

139

135

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Purpose of review To provide an update on paraneoplastic neurological syndromes (PNS), the involved tumors and types of immune responses. Recent findings PNS are a diverse group of syndromes that may present as a relatively isolated syndrome such as predominant cerebellar degeneration or limbic encephalitis or with more complex phenotypes such as diffuse encephalomyelitis that affects different levels of the neuraxis producing a variety of clinical manifestations. The detection of specific anti-neuronal antibodies can confirm or strongly support the paraneoplastic etiology of the syndrome and direct the search for the associated cancer. Previously thought to be unresponsive to therapy it has recently been shown that there are some antibody associated PNS that are highly responsive to treatment, including tumor directed therapies and immunotherapy. Summary The recognition of PNS is important for the early detection of an underlying malignancy and prompt initiation of therapies, which offers the best opportunity to stabilize or improve the neurological deficits and for those syndromes associated with cell surface antibodies usually results in substantial improvement or full recovery.

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Section: Paraneoplastic Cerebellar Degenerationmentioning

confidence: 99%

Update on neurological paraneoplastic syndromes

Höftberger

Rosenfeld

Dalmau

2015

Current Opinion in Oncology

139

135

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“…Given the intracellular antigen location of the antineuronal antibodies, patients have limited improvement despite treatment. Additionally, patients do not typically respond to tumor‐directed or immunotherapy, although they may benefit from physical rehabilitation …”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic neurologic syndrome as a presentation of underlying breast malignancy

et al. 2018

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While breast cancer most commonly presents as a screen-detected mammographic finding or a breast symptom, in very rare instances it may first present as a paraneoplastic neurologic syndrome (PNS; Surg Case Rep, 2015;1:59; Ann Neurol 2004;56:715). Fewer than 1% of breast cancer patients have PNS, and an even smaller percentage initially present with neurologic symptoms (J Neurol Neurosurg Psychiatry, 2004;75:ii43). We report a case series of three patients who presented with neurological disorders suspicious for PNS, and were subsequently found to have underlying breast cancer. We follow this with a discussion of key clinical features of management considerations in paraneoplastic syndromes secondary to breast malignancy. K E Y W O R D Sbreast cancer, imaging, paraneoplastic neurologic syndrome

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“…Cancer rehabilitation is recently recognized as an integral part of continuum of care in cancer management and emerging evidences support that rehabilitation improves physical functioning, strength, psychosocial health outcome, quality of life and immune function [8,9]. At present, only limited information is availablefor rehabilitation outcomes of PNS population although numerous published literatures are available for its pathophysiology, medical treatment and prognosis [11,12]. This case report intends to appreciate early awareness of classical presentation of POMS, better functional outcome with comprehensive rehabilitation in collaboration with prompt medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Rare Paraneoplastic Opsoclonus Myoclonus Syndrome (POMS) in a Recurrent Breast Cancer Patient: Importance of Early Recognition of POMS and Initiation of Rehabilitation Intervention

Sh¹,

Tp²,

YeowLeng³

2017

JCR

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Background: Opsoclonus myoclonus syndrome is a rare condition characterized by the amalgamation of multidirectional saccades of eye movements, involuntary myoclonus predominantly affecting trunk and limbs and cerebellar ataxia. Typical malignancies associated with paraneoplatic opsoclonus myoclonus syndrome (POMS) in adults are small cell lung carcinoma and breast cancer with variable outcomes. Case Report: The authors report here a patient with stage IV recurrent right breast cancer, presenting to the hospital with unsteady gait, jerky movements of the limbs and body. She was clinically diagnosed with POMS with positive cerebrospinal fluid anti-Ri antibody. Medical treatment with intravenous methylprednisolone and early initiation of rehabilitation improved her balance, coordination and ataxia. This led to an overall improvement in her physical function. Conclusion: This case illustrates the importance of early recognition, prompt treatment of POMS and initiation of rehabilitation in achieving better functional outcomes.

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Inpatient Rehabilitation Performance of Patients With Paraneoplastic Cerebellar Degeneration

Cited by 17 publications

References 10 publications

Update on neurological paraneoplastic syndromes

Update on neurological paraneoplastic syndromes

Paraneoplastic neurologic syndrome as a presentation of underlying breast malignancy

Rare Paraneoplastic Opsoclonus Myoclonus Syndrome (POMS) in a Recurrent Breast Cancer Patient: Importance of Early Recognition of POMS and Initiation of Rehabilitation Intervention

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