Input from central nucleus of the amygdala efferents to pericoerulear dendrites, some of which contain tyrosine hydroxylase immunoreactivity

Bockstaele, Elisabeth J. Van; Chan, June; Pickel, Virginia M.

doi:10.1002/(sici)1097-4547(19960801)45:3<289::aid-jnr11>3.0.co;2-#

Cited by 74 publications

(43 citation statements)

References 51 publications

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“…Careful studies of the inputs to the core of the locus coeruleus reveal that it receives a very restricted range of inputs, mainly from the rostral ventrolateral and paramedian medulla (including major inputs from the C1 and C3 adrenergic cell group, as well as from non-catecholaminergic neurons) and from the lateral hypothalamic area, paraventricular nucleus and ventrolateral preoptic nucleus (Aston- Jones et al, 1986;Aston-Jones, 1986, 1987;Guyenet and Young, 1987;Pieribone et al, 1988;Astier et al, 1990;Luppi et al, 1995;Sherin et al, 1998;Lu et al, 2002;Reyes et al, 2005;Abbott et al, 2012;Sevigny et al, 2012b). However, studies focusing on inputs to the more distal dendrites of the locus coeruleus neurons have demonstrated afferents from other components of the central autonomic system, including the medial prefrontal cortex, bed nucleus of the stria terminalis, central nucleus of the amygdala (including a dynorphin/CRF containing afferent pathway), and nucleus of the solitary tract (Van Bockstaele et al, 1996;Van Bockstaele et al, 1999a, 1999bBajic et al, 2000;Reyes et al, 2008Reyes et al, , 2011Gompf et al, 2010).…”

Section: Locus Coeruleusmentioning

confidence: 99%

Central Autonomic System

Saper

Stornetta

2015

The Rat Nervous System

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Section: Locus Coeruleusmentioning

confidence: 99%

Central Autonomic System

Saper

Stornetta

2015

The Rat Nervous System

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“…This is similar to earlier work in the rat showing that neither frontal cortex nor amygdala responses had shorter latencies than LC in a go-nogo task Sara 2004, 2005). Thus, although LC neurons receive strong inputs from the amygdala (Bouret et al 2003;Van Bockstaele et al 1996), as well as orbitofrontal and cingulate cortices (Aston-Jones and Cohen 2005), cue responses in this task are probably not triggered, or at least not solely, by any of these telencephalic structures. The strong correlation between LC and Pavlovian responses, and probably with other instinctive and emotional responses, suggests that LC activation could be triggered by inputs from the brain stem.…”

Section: Relation With Activity Of Other Structures In the Reward Schmentioning

confidence: 99%

“…The strength of activation is correlated with the strength of autonomic, orienting, or approach behaviors occurring in response to the stimuli (Abercrombie and Jacobs 1987; Aston-Jones and Bloom 1981; Grant et al 1988;Vankov et al 1995). These spontaneous responses to salient stimuli are part of the animal's innate behavioral repertoire and can be regarded as instinctive.…”

Section: Introductionmentioning

confidence: 99%

Relation of Locus Coeruleus Neurons in Monkeys to Pavlovian and Operant Behaviors

Bouret

Richmond²

2009

Journal of Neurophysiology

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Bouret S, Richmond BJ. Relation of locus coeruleus neurons in monkeys to Pavlovian and operant behaviors. J Neurophysiol 101: 898 -911, 2009. First published December 17, 2008 doi:10.1152/jn.91048.2008. Noradrenaline is released throughout the forebrain from locus coeruleus (LC) projections in close temporal proximity to emotional and goal-directed events. To examine interactive influences of these processes on LC neuronal activity, we used a task where Pavlovian and operant processes vary and can be easily identified. We recorded 69 single LC neurons from two monkeys performing a task where cues indicate the progression through schedules of one, two, or three operant trials. Pavlovian responses and phasic LC activations occur following the appearance of conditioned visual cues (54/69 neurons), especially those at the beginning of new schedules, whether the current trial will be rewarded (single trial schedule) or not (2 or 3 trial schedules), and after visual imperative signals eliciting the operant response (64/69 neurons), whether the current trial will be rewarded or not. The modulation of LC responses seems to be relatively independent of attention or motivation, because the responses do not covary with operant performance in the task. The magnitude of LC responses across the schedules varied in close relation to the intensity of Pavlovian behavior but these responses were also modulated by operant processes. Our conclusion is that LC activation occurs when task-relevant stimuli evoke a conditioned instinctive (Pavlovian) response, with the strength of the activation also being modulated by goal-directed processes. Thus locus coeruleus neurons broadcast information about stimulus-elicited primitive and goal-directed behaviors to forebrain structures important for executive functions and emotions.

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“…The LC is one of the primary sources of norepinephrine (NE) in the mammalian brain and has an extensive network of NA terminals that innervate numerous regions, including the extended amygdala ( Van Bockstaele et al, 1996aMoore, 1978;Phelix et al, 1992;Swanson and Hartman, 1975;Swanson, 1976). The LC-NE system is a critical stress response system in the mammalian brain in which stress neuromodulators and endogenous opioids intersect ( Van Bockstaele et al, 1996bValentino et al, 1992Valentino et al, , 2001).…”

Section: Introductionmentioning

confidence: 99%

Locus Coeruleus Kappa-Opioid Receptors Modulate Reinstatement of Cocaine Place Preference Through a Noradrenergic Mechanism

Al‐Hasani

McCall

Foshage

et al. 2013

Neuropsychopharmacol

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Activation of kappa-opioid receptors (KORs) in monoamine circuits results in dysphoria-like behaviors and stress-induced reinstatement of drug seeking in both conditioned place preference (CPP) and self-administration models. Noradrenergic (NA) receptor systems have also been implicated in similar behaviors. Dynorphinergic projections terminate within the locus coeruleus (LC), a primary source of norepinephrine in the forebrain, suggesting a possible link between the NA and dynorphin/kappa opioid systems, yet the implications of these putative interactions have not been investigated. We isolated the necessity of KORs in the LC in kappa opioid agonist (U50,488)-induced reinstatement of cocaine CPP by blocking KORs in the LC with NorBNI (KOR antagonist). KOR-induced reinstatement was significantly attenuated in mice injected with NorBNI in the LC. To determine the sufficiency of KORs in the LC on U50,488-induced reinstatement of cocaine CPP, we virally re-expressed KORs in the LC of KOR knockout mice. We found that KORs expression in the LC alone was sufficient to partially rescue KOR-induced reinstatement. Next we assessed the role of NA signaling in KOR-induced reinstatement of cocaine CPP in the presence and absence of a a2-agonist (clonidine), b-adrenergic receptor antagonist (propranolol), and b 1 -and b 2 -antagonist (betaxolol and ICI-118,551 HCl). Both the blockade of postsynaptic b 1 -adrenergic receptors and the activation of presynaptic inhibitory adrenergic autoreceptors selectively potentiated the magnitude of KOR-induced reinstatement of cocaine CPP but not cocaine-primed CPP reinstatement. Finally, viral restoration of KORs in the LC together with b-adrenergic receptor blockade did not potentiate KOR-induced reinstatement to cocaine CPP, suggesting that adrenergic receptor interactions occur at KOR-expressing regions external to the LC. These results identify a previously unknown interaction between KORs and NA systems and suggest a NA regulation of KOR-dependent reinstatement of cocaine CPP.

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Input from central nucleus of the amygdala efferents to pericoerulear dendrites, some of which contain tyrosine hydroxylase immunoreactivity

Cited by 74 publications

References 51 publications

Central Autonomic System

Central Autonomic System

Relation of Locus Coeruleus Neurons in Monkeys to Pavlovian and Operant Behaviors

Locus Coeruleus Kappa-Opioid Receptors Modulate Reinstatement of Cocaine Place Preference Through a Noradrenergic Mechanism

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