Input-Specific GABAergic Signaling to Newborn Neurons in Adult Dentate Gyrus

Markwardt, Sean J.; Wadiche, Jacques I.; Overstreet-Wadiche, Linda

doi:10.1523/jneurosci.2727-09.2009

Cited by 85 publications

(86 citation statements)

References 55 publications

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“…Moreover, optogenetic control of dentate PV + neuron activity, but not SST + or vasoactive intestinal polypeptide (VIP + ) interneurons, dictates the radial glia-like neural-stem-cell decision between quiescence and activation (Song et al 2012b). In contrast to the direct synaptic inputs onto immature neurons in POMC-EGFP mice (Markwardt et al 2009), no apparent functional GABAergic synaptic responses were detected when radial glia-like NSCs were recorded in this and previous studies (Wang et al 2005), suggesting that GABA spillover from activated PV + interneuron-mature GC synapses indirectly regulates nearby radial stem cells. More recently, we showed that PV + interneurons make direct synaptic contacts with proliferating neuroblasts and regulate their survival and development in the adult DG (Song et al 2012b, 2013).…”

Section: Circuitry Regulation Of Adult Hippocampal Neurogenesiscontrasting

confidence: 93%

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

Song

Olsen

Sun

et al. 2016

Cold Spring Harb Perspect Biol

109

108

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The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogenesis, recapitulates neural developmental events in two specialized adult brain regions: the lateral ventricles of the forebrain. Recent studies have begun to delineate how the existing neuronal circuits influence the dynamic process of adult neurogenesis, from activation of quiescent neural stem cells (NSCs) to the integration and survival of newborn neurons. Here, we review recent progress toward understanding the circuit-based regulation of adult neurogenesis in the hippocampus and olfactory bulb.

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Section: Circuitry Regulation Of Adult Hippocampal Neurogenesiscontrasting

confidence: 93%

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

Song

Olsen

Sun

et al. 2016

Cold Spring Harb Perspect Biol

109

108

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“…Interestingly, innervations by interneurons whose somata and axonal arborization are located in the ML (e.g., so-called MOPP cells) appear to lag behind, which may reflect the time required for differentiation of the granule neuron dendrite within the ML. Occasionally, we also observed RABV-traced neurons classified as Ivy/neurogliaform cells, characterized by their compact dendritic tree and dense axonal arborization (29). Somewhat surprisingly, we detected labeling of hilar mossy cells starting from 5 to 10 d after the generation of newborn neurons, suggesting that these experience their first glutamatergic synaptic input from this type of hilar neuron.…”

Section: Discussionmentioning

confidence: 60%

Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb

Deshpande

Bergami

Ghanem

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

169

190

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Identifying the connectome of adult-generated neurons is essential for understanding how the preexisting circuitry is refined by neurogenesis. Changes in the pattern of connectivity are likely to control the differentiation process of newly generated neurons and exert an important influence on their unique capacity to contribute to information processing. Using a monosynaptic rabies virus-based tracing technique, we studied the evolving presynaptic connectivity of adult-generated neurons in the dentate gyrus (DG) of the hippocampus and olfactory bulb (OB) during the first weeks of their life. In both neurogenic zones, adult-generated neurons first receive local connections from multiple types of GABAergic interneurons before long-range projections become established, such as those originating from cortical areas. Interestingly, despite fundamental similarities in the overall pattern of evolution of presynaptic connectivity, there were notable differences with regard to the development of cortical projections: although DG granule neuron input originating from the entorhinal cortex could be traced starting only from 3 to 5 wk on, newly generated neurons in the OB received input from the anterior olfactory nucleus and piriform cortex already by the second week. This early glutamatergic input onto newly generated interneurons in the OB was matched in time by the equally early innervations of DG granule neurons by glutamatergic mossy cells. The development of connectivity revealed by our study may suggest common principles for incorporating newly generated neurons into a preexisting circuit.adult neurogenesis | synaptic tracing | adult neural stem cell | functional integration | pseudotransduction

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“…(2) Then, neural progenitors begin to be innervated by local interneurons through input-specific GABAergic signaling [47, 48] . This initial synaptic transmission is slow and displays immature properties due to the relatively low concentration of GABA receptors on the newborn progeny [49] .…”

Section: Regulation Of Adult Neural Stem Cells and Their Progenymentioning

confidence: 99%

Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny

Crowther

Song

2014

Neurosci. Bull.

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Adult neural stem cells (NSCs) reside in a restricted microenvironment, where their development is controlled by subtle and presently underexplored cues. This raises a significant question: what instructions must be provided by this supporting niche to regulate NSC development and functions? Signaling from the niche is proposed to control many aspects of NSC behavior, including balancing the quiescence and proliferation of NSCs, determining the cell division mode (symmetric versus asymmetric), and preventing premature depletion of stem cells to maintain neurogenesis throughout life. Interactions between neurogenic niches and NSCs also govern the homeostatic regulation of adult neurogenesis under diverse physiological, environmental, and pathological conditions. An important implication from revisiting many previously-identified regulatory factors is that most of them (e.g., the antidepressant fluoxetine and exercise) affect gross neurogenesis by acting downstream of NSCs at the level of intermediate progenitors and neuroblasts, while leaving the NSC pool unaffected. Therefore, it is critically important to address how various niche components, signaling pathways, and environmental stimuli differentially regulate distinct stages of adult neurogenesis.

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Input-Specific GABAergic Signaling to Newborn Neurons in Adult Dentate Gyrus

Cited by 85 publications

References 55 publications

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb

Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny

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