A growing body of evidence links obstructive sleep apnea (OSA) with hypertension. The authors performed a retrospective cohort study using the University Hospital of Larissa Sleep Apnea Database (1501 patients) to determine predictors of in-laboratory diagnosed OSA for development of hypertension. Differences in continuous variables were assessed via independent samples t test, whereas discrete variables were compared by Pearson's chi-square test. Multivariate analysis was performed via discriminant function analysis. There were several significant differences between hypertensive and normotensive patients. Age, body mass index, comorbidity, daytime oxygen saturation, and indices of hypoxia during sleep were deemed the most accurate predictors of hypertension, whereas apnea-hypopnea index and desaturation index were not. Obstructive sleep apnea (OSA) is characterized by repetitive interruption of ventilation during sleep caused by collapse of the pharyngeal airway. The apneahypopnea index (AHI) is the number of apneas and hypopneas per hour of sleep and has been used to characterize the severity of the OSA syndrome (OSAS). A diagnosis of OSAS is accepted when a patient has an AHI >5 and associated symptoms (eg, excessive daytime sleepiness, fatigue, or impaired cognition) or an AHI ≥15 regardless of associated symptoms.