İnsan İmmün Yetmezlik Virüsü ile İnfekte Anne Bebekleri ve Perinatal Geçisin Değerlendirilmesi

Çay, Ümmühan; TAPAÇ, Nisa Nur; Gündeşli̇oğlu, Özlem Özgür; Alabaz, Derya

doi:10.12956/tchd.980415

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…Patients may experience localized pain, swelling, and stiffness in the affected area, often accompanied by systemic symptoms, such as fever, night sweats, and weight loss. As the disease progresses, more severe signs, such as spinal deformities, neurological deficits due to spinal cord compression, or joint dysfunction, can occur [13][14][15][16]. The diagnosis of bone TB relies on a combination of clinical evaluation, imaging techniques such as X-rays and MRI, and laboratory tests, including biopsies and microbiological cultures [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Strategies for Bone Tuberculosis Management

Luo,

Chen,

Chen

et al. 2024

Pharmaceuticals

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Bone tuberculosis, an extrapulmonary manifestation of tuberculosis, presents unique treatment challenges, including its insidious onset and complex pathology. While advancements in anti-tubercular therapy have been made, the efficacy is often limited by difficulties in achieving targeted drug concentrations and avoiding systemic toxicity. The intricate bone structure and presence of granulomas further impede effective drug delivery. Nano-drug delivery systems have emerged as a promising alternative, offering the enhanced targeting of anti-tubercular drugs. These systems, characterized by their minute size and adaptable surface properties, can be tailored to improve drug solubility, stability, and bioavailability, while also responding to specific stimuli within the bone TB microenvironment for controlled drug release. Nano-drug delivery systems can encapsulate drugs for precise delivery to the infection site. A significant innovation is their integration with prosthetics or biomaterials, which aids in both drug delivery and bone reconstruction, addressing the infection and its osteological consequences. This review provides a comprehensive overview of the pathophysiology of bone tuberculosis and its current treatments, emphasizing their limitations. It then delves into the advancements in nano-drug delivery systems, discussing their design, functionality, and role in bone TB therapy. The review assesses their potential in preclinical research, particularly in targeted drug delivery, treatment efficacy, and a reduction of side effects. Finally, it highlights the transformative promise of nanotechnology in bone TB treatments and suggests future research directions in this evolving field.

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