Insect Allergy

Mosbech, H.

doi:10.1111/j.1398-9995.1984.tb00876.x

Cited by 27 publications

(7 citation statements)

References 18 publications

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“…In the present study sample, of the children with allergic reactions to insect sting, those who had an atopic disease had significantly more severe reactions (SSR) than those who did not. This finding is in agreement with previous studies (16–18), but disagrees with an earlier one in a small cohort (117 patients) that observed no correlation between severity of the reaction and atopic disposition (26).…”

Section: Discussionsupporting

confidence: 82%

Increased rate and greater severity of allergic reactions to insect sting among schoolchildren with atopic diseases

Graif

Romano-Zelekha

Livne³

et al. 2009

Pediatric Allergy Immunology

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The question of whether atopic diseases are a risk factor for allergic reactions to insect sting is still unresolved. The aim of this study was to evaluate the association between atopic diseases (asthma, allergic rhinitis, atopic eczema) and allergic reactions to insect stings among schoolchildren in Israel. A self-report questionnaire of the International Study of Asthma and Allergies in Childhood was administered to a national sample of 13-14-yr-old schoolchildren. Questions regarding reactions to insect stings were added. A total of 10,021 questionnaires were available for analysis. Among the children who reported insect stings (56.3%), the prevalence of current asthma was 6.0%, of allergic rhinitis, 10.5%, and of atopic eczema, 8.7%, with no significant differences from the whole study population. Among children with any of the atopic diseases, 36.9% reported an allergic reaction to insect sting compared to 24.8% of the non-atopic children (p < 0.0001). On multivariate analysis, asthma, allergic rhinitis, and atopic eczema were found to be significant risk factors for allergic reactions of any severity. Children in the atopic group had a significantly higher rate of severe allergic reactions than the non-atopic children, and relatively higher rates of milder ones (p < 0.0001). Asthmatic patients with severe allergic reactions had more parameters of severe asthma than asthmatic patients with mild or no reactions. In conclusions, allergic diseases are associated with a higher rate and greater severity of allergic reactions to insect sting in children. The severity of the allergic reaction is related to the severity of the asthma symptoms.

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Section: Discussionsupporting

confidence: 82%

Increased rate and greater severity of allergic reactions to insect sting among schoolchildren with atopic diseases

Graif

Romano-Zelekha

Livne³

et al. 2009

Pediatric Allergy Immunology

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“…a painful reaction a long time ago could be remembered as larger than it actually was. Another major explanation for the discrepancy might be the decline in specific IgE over time [13,14]. …”

Section: Discussionmentioning

confidence: 99%

Insect Sting Reactions and Specific IgE to Venom and Major Allergens in a General Population

Mosbech

Tang²,

Linneberg³

2016

Int Arch Allergy Immunol

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Background: Insect sting reactions are frequently reported, but population studies documenting the frequency and the relation to IgE-sensitization and serum tryptase are scarce. Methods: Questionnaire data and results from measurements of specific IgE against venom, major allergens and cross-reacting carbohydrate determinants (CCDs) were collected from 2,090 adult participants in a cross-sectional survey. Results: 13% of the population reported symptoms of sting reactions and about half were systemic in nature. In all, 15% were sensitized to venom but only 31% of these had reacted to stings and only 38% of those with reactions had IgE to venom. In addition, 12% with IgE to venom were double-sensitized (DS), i.e. to both bee and wasp venom. Among DS IgE to major venom allergens, rApi m 1, rVes v 1 and rVes v 5 were negative and of no help in 31%, but 59% could be identified as likely sensitized to bee or wasp. IgE to CCDs occurred in only 0.7%, but 80% of these were DS. Finally, 36% with IgE to CCDs had had symptoms, mostly local. Serum tryptase was not associated with a history of sting reactions. Conclusions: In a temperate climate, self-reported insect sting reactions and sensitization to venom are frequent, but in most cases, these are not seen in the same individual. In DS individuals, measurements of IgE to major allergens can be helpful in some but not all cases and additional analyses are needed. IgE to CCDs may have some clinical relevance.

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“…Yellow jackets (Vespula) represent a latent risk for people allergic against the venom of these insects [1]. In contrast to pollen-allergic patients, who suffer seasonally from diverse allergic symptoms, insect-allergic individuals are affected by insect stings only and may therefore not be aware of their disposition until stung for a second time.…”

Section: Introductionmentioning

confidence: 99%

A proteomic study of the major allergens from yellow jacket venoms

et al. 2007

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The venoms of stinging insects belong to the most dangerous allergen sources and can cause fatal anaphylactic reactions. Reliable prediction of a patient's risk to anaphylactic reactions is vital, and diagnosis requires the knowledge of the relevant allergens. Recently, a new hyaluronidase -like glycoprotein from Vespula vulgaris (Ves v 2b) was identified. This led us to investigate hyaluronidases and also other major allergens from V. germanica and four additional Vespula species. By MALDI-Q-TOF-MS, the new hyaluronidase-like protein was shown to be the major component of the 43-kDa band in all Vespula species studied. LC-ESI-Q-TOF-MS/MS sequencing of Ves g 2a and Ves g 2b facilitated the cloning of their cDNA. Ves v 2b and Ves g 2b turned out to be essentially identical on protein level. Whereas the less abundant "a" form displayed enzymatic activity, the new "b" homologue did not. This is probably caused by amino acid exchanges in the active site, and it raises questions about the physiological role of this protein. Sequence comparisons by MS/MS of antigen 5 and phospholipases from V. vulgaris, germanica, maculifrons, pensylvanica, flavopilosa and squamosa revealed the latter as a taxonomic outlier and led to the discovery of several not previously reported amino acid differences.

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Insect Allergy

Cited by 27 publications

References 18 publications

Increased rate and greater severity of allergic reactions to insect sting among schoolchildren with atopic diseases

Increased rate and greater severity of allergic reactions to insect sting among schoolchildren with atopic diseases

Insect Sting Reactions and Specific IgE to Venom and Major Allergens in a General Population

A proteomic study of the major allergens from yellow jacket venoms

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