Insect antifeedant and growth regulating activities of quassinoids from Samadera indica

Govindachari, T. R.; Kumari, G. N. Krishna; Gopalakrishnan, Geetha; Suresh, G.; Wesley, S. Daniel; Sreelatha, T.

doi:10.1016/s0367-326x(00)00342-7

Cited by 27 publications

(16 citation statements)

References 2 publications

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“…Our present investigation showed that larvae of An. gambaie are susceptible to simalikalactone D. Triterpenoids are known to possess insect growth regulation activity against a variety of agricultural pests (Govindachari et al, 2001). Quassinoids, being modified triterpenoids can be expected to show similar activity; however, Q. africana had not so far been tested for activity against insects of medical importance.…”

Section: Resultsmentioning

confidence: 99%

Larvicidal properties of simalikalactone d from Quassia africana (simaroubaceae) Baill and Baill, on the malaria vector Anopheles gambiae

Sama¹,

Ajaiyeoba²,

Choudhary³

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Botanical and microbial insecticides have been increasingly used for the control of mosquito given their efficacy and documented nontoxic effects on non-target organisms. The discovery of new insecticides is imperative because of the development of resistance by the mosquitoes to the readily available insecticides. The aim of this study was therefore to isolate and characterize compounds from a local medicinal plant, Quassia africana Baill and Baill (Simaroubaceae) that were toxic to Anopheles gambiae. Material and methods:The methanol extracts of the leaves, stem and roots of Quassia africana were tested against fourth instar larvae of An. gambiae. The root extract was partitioned into hexane, chloroform and ethyl acetate and the resulting extracts screened for larvicidal properties. The extracts and the fraction with the highest bioactivity were subjected to repeated column chromatography and isolated compounds evaluated for potential toxicity to An. gambiae larvae. The structure of the active compound was elucidated using spectroscopic techniques. The root extract showed the strongest activity profile (LC 50 = 17.58 μg/mL). The chloroform soluble fraction obtained after partitioning the crude extract into solvents based on polarities was the most toxic. Further bio-activity-guided chromatographic separation of the chloroform fraction of the root extract led to the identification and isolation of a simalikalactone D as the larvicidal compound in Q. africana (LC 50 = 1.25 μg/mL). Results: Results suggest that Q. africana may serve as a source for vector control agent for malaria. Conclusion: Simalikalactone D was identified as the larvicidal compound in Q. africana (LC 50 = 1.25 μg/mL).

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Section: Resultsmentioning

confidence: 99%

Larvicidal properties of simalikalactone d from Quassia africana (simaroubaceae) Baill and Baill, on the malaria vector Anopheles gambiae

Sama¹,

Ajaiyeoba²,

Choudhary³

2014

Afr. J. Trad. Compl. Alt. Med.

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“…Quassinoids, as modified triterpenoids, can be expected to show similar activity. Furthermore, quassinoids isolated from the seeds and bark of Samadera indica (Simaroubaceae), have been described as altering the insect tobacco cutworm feeding behavior and growth regulation (Govindachari et al 2001), as well as the methanol extract of the aerial parts of Quassia sp. aff.…”

Section: Resultsmentioning

confidence: 99%

Insecticidal activity of cerrado plant extracts on Rhodnius milesi Carcavallo, Rocha, Galvão & Jurberg (Hemiptera: Reduviidae), under laboratory conditions

Coelho¹,

Paula²,

Espindola³

2006

Neotrop. Entomol.

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-Chagas' disease is chiefly transmitted by feces of haematophagous bugs (Triatominae) that ingested Trypanosoma cruzi from blood of infected people or animals. Pyrethroids have been the main insecticides used against these insects. However, some populations of insects have shown significant levels of resistance to several pyrethroids, indicating the need of new insecticides for the control of triatomines. Insecticidal activity of 24 Cerrado plant extracts belonging to five species of four families were assayed on fourth instar nymphs of Rhodnius milesi Carcavallo, Rocha, Galvão & Jurberg (Hemiptera: Reduviidae), under laboratory conditions. For the extract application on triatomines, 50 μg of the extract were topically applied in duplicate on dorsal tergites of ten insects. Insects topically treated with acetone, ethanol, as well as insects with no treatment were used as controls. Triatomines were observed over a 28-day period. Hexanic and ethanolic extracts of Simarouba versicolor, Guarea kunthiana, Guarea guidonia and Talauma ovata caused mortality between 20% and 95% of R. milesi in comparison with the controls, which showed no insect mortality. These preliminary data suggest that the ethanolic extract of the root bark of S. versicolor and the hexanic extract of the root of G. guidonia, responsible for a 95% and 75% insect mortality, respectively, should be chemically investigated and monitored through biological assays in order to determine their insecticidal components, that could be used as a molecular model or as biorational compounds for use in insect control programmes.

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“…Four quassinoids isolated from Samadera indica Gaert. (Simaroubaceae) showed antifeedant and growth regulator activity on the tobacco budworm Spodoptera litura Fabricius (Lepidoptera: Noctuidae) (Govindachari et al 2001 (Leskinen et al 1984). Daido et al (1993Daido et al ( , 1995 evaluated antifeedant and insecticidal activities of some quassinoids against third instar larvae of the diamondback moth [Plutella xylostella L. (Lepidoptera: Plutellidae)], suggesting a possible structure/activity relationship.…”

Section: Discussionmentioning

confidence: 99%

Bioassay-oriented isolation of an insecticide from Ailanthus altissima

Feo

Mancini

Voto

et al. 2009

Journal of Plant Interactions

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The tree-of-heaven, Ailanthus altissima Swingle(Simaroubaceae), was studied for its potential insecticide activity against the pea aphid, Acyrtosiphon pisum (Harris). First instar aphids were dipped in water solutions of root extract and of leaf extract of A. altissima, and this was followed by bioassay-oriented fractioning of leaf extract (more active in bioassays) with petroleum ether, chloroform, chloroform-methanol, methanol and water, and of chromatographic fractions. The putative active constituent ailanthone, isolated from the plant resulting in the highest aphid mortality, has been assayed as a pure compound in different concentrations, proving to be responsible, for the insecticidal activity reported

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Insect antifeedant and growth regulating activities of quassinoids from Samadera indica

Cited by 27 publications

References 2 publications

Larvicidal properties of simalikalactone d from <i>Quassia africana</i> (simaroubaceae) Baill and Baill, on the malaria vector <i>Anopheles gambiae</i>

Larvicidal properties of simalikalactone d from <i>Quassia africana</i> (simaroubaceae) Baill and Baill, on the malaria vector <i>Anopheles gambiae</i>

Insecticidal activity of cerrado plant extracts on Rhodnius milesi Carcavallo, Rocha, Galvão & Jurberg (Hemiptera: Reduviidae), under laboratory conditions

Bioassay-oriented isolation of an insecticide from Ailanthus altissima

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