Insect diapause-specific peptide from the leaf beetle has consensus with a putative iridovirus peptide

Tanaka, Hiromasa; Satô, Kenji; Saito, Yuki; Yamashita, Tetsuro; Agoh, Masanobu; Okunishi, Junji; Tachikawa, Eiichi; Suzuki, Kunihiro

doi:10.1016/j.peptides.2003.07.021

Cited by 52 publications

(36 citation statements)

References 30 publications

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“…gallerimycin, X-tox) constitute a diverse family of AMPs, most of which are active against bacteria or fungi (Matsuyama and Natori, 1988; Schuhmann et al, 2003; Tanaka et al, 2003; d'Alencon et al, 2013; Zhu and Gao, 2013). These molecules may adopt an αβ fold stabilized by three disulfide bonds between Cys-1 and 4, Cys-2 and 5, Cys-3 and 6 (Fig.…”

Section: Resultsmentioning

confidence: 99%

A genome-wide analysis of antimicrobial effector genes and their transcription patterns in Manduca sexta

Cao

et al. 2015

Insect Biochemistry and Molecular Biology

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Antimicrobial proteins/peptides (AMPs) are effectors of innate immune systems against pathogen infection in multicellular organisms. Over half of the AMPs reported so far come from insects, and these effectors act in concert to suppress or kill bacteria, fungi, viruses, and parasites. In this work, we have identified 86 AMP genes in the Manduca sexta genome, most of which seem likely to be functional. They encode 15 cecropins, 6 moricins, 6 defensins, 3 gallerimycins, 4 X-tox splicing variants, 14 diapausins, 15 whey acidic protein homologs, 11 attacins, 1 gloverin, 4 lebocins, 6 lysozyme-related proteins, and 4 transferrins. Some of these genes (e.g. attacins, cecropins) constitute large clusters, likely arising after rounds of gene duplication. We compared the amino acid sequences of M. sexta AMPs with their homologs in other insects to reveal conserved structural features and phylogenetic relationships. Expression data showed that many of them are synthesized in fat body and midgut during the larval-pupal molt. Certain genes contain one or more predicted κB binding sites and other regulatory elements in their promoter regions, which may account for the dramatic mRNA level increases in fat body and hemocytes after an immune challenge. Consistent with these strong mRNA increases, many AMPs become highly abundant in the larval plasma at 24 h after the challenge, as demonstrated in our previous peptidomic study. Taken together, these data suggest the existence of a large repertoire of AMPs in M. sexta, whose expression is up-regulated via immune signaling pathways to fight off invading pathogens in a coordinated manner.

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Section: Resultsmentioning

confidence: 99%

A genome-wide analysis of antimicrobial effector genes and their transcription patterns in Manduca sexta

Cao

et al. 2015

Insect Biochemistry and Molecular Biology

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“…Continuous rearing of G. atrocyanea on the artificial diet will also facilitate research on the mechanisms of obligatory diapausing and overwintering. Currently, Tanaka et al (1998Tanaka et al ( , 2003 have identified an endogenous diapause and hibernationspecific peptide from the leaf beetle. The diet and rearing system described here will be useful for providing beetles on a year-reared basis for designed experiments.…”

Section: Discussionmentioning

confidence: 99%

Continuous rearing of an entomoresource, the leaf beetle, Gastrophysa atrocyanea Motschulsky (Coleoptera: Chrysomelidae) on artificial diets

Ojima

Ikeda²,

Koike³

et al. 2005

Appl. Entomol. Zool.

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“…In addition to the core iridovirid genes involved in replication and nucleotide metabolism, other genes of interest in IIV-6 include an inhibitor of apoptosis ( iap ), an NAD + -dependent DNA ligase, and putative homologs of peptides with antibacterial and antifungal properties (Jakob et al 2001;Tanaka et al 2003). Two adjacent ORFs have been detected in IIV-6 with homology to eukaryotic poly(ADPribosyl)transferase (pART), an enzyme that plays an important role in genome repair and maintenance (Otto et al 2005).…”

Section: Genomic Characteristicsmentioning

confidence: 99%

Family Iridoviridae: Poor Viral Relations No Longer

Chinchar

Hyatt

Miyazaki

et al. 2009

Current Topics in Microbiology and Immunology

182

205

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Members of the family Iridoviridae infect a diverse array of invertebrate and cold-blooded vertebrate hosts and are currently viewed as emerging pathogens of fish and amphibians. Iridovirid replication is unique and involves both nuclear and cytoplasmic compartments, a circularly permuted, terminally redundant genome that, in the case of vertebrate iridoviruses, is also highly methylated, and the efficient shutoff of host macromolecular synthesis. Although initially neglected largely due to the perceived lack of health, environmental, and economic concerns, members of the genus Ranavirus , and the newly recognized genus Megalocytivirus , are rapidly attracting

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Insect diapause-specific peptide from the leaf beetle has consensus with a putative iridovirus peptide

Cited by 52 publications

References 30 publications

A genome-wide analysis of antimicrobial effector genes and their transcription patterns in Manduca sexta

A genome-wide analysis of antimicrobial effector genes and their transcription patterns in Manduca sexta

Continuous rearing of an entomoresource, the leaf beetle, Gastrophysa atrocyanea Motschulsky (Coleoptera: Chrysomelidae) on artificial diets

Family Iridoviridae: Poor Viral Relations No Longer

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