Insect Growth Regulators with Juvenile Hormone Activity

Staal, Gerardus B.

doi:10.1146/annurev.en.20.010175.002221

Cited by 312 publications

(137 citation statements)

References 87 publications

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“…79,80) Many other analogs of varying chemical structure have been found to act as JH mimics on one or several different insect species. 81,82) These JH analogs are very effective in disrupting both insect embryonic development 82,83) and metamorphosis. 80,82) They also affect caste differentiation in social insects.…”

Section: Natural and Synthetic Jh Mimics As Insect Growth Regulatorsmentioning

confidence: 99%

“…81,82) These JH analogs are very effective in disrupting both insect embryonic development 82,83) and metamorphosis. 80,82) They also affect caste differentiation in social insects. 79) Some of these JH mimics are toxic to aquatic insects such as the dragonfly and the back swimmer 79) and to crustaceans such as shrimp, crabs and lobsters 84,85) and disrupt sex determination of the crustacean Daphnia magna.…”

Section: Natural and Synthetic Jh Mimics As Insect Growth Regulatorsmentioning

confidence: 99%

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Insect juvenile hormone action as a potential target of pest management

Minakuchi

Riddiford

2006

J. Pestic. Sci.

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Juvenile hormone (JH) is a sesquiterpenoid hormone that regulates growth and development in insects. Since JH is a hormone specific to insects and other arthropods, compounds disrupting JH action in insects are expected to be ideal insecticides with low toxicity to non-target organisms. Many natural or synthetic analogs with JH-like or anti-JH activity have been identified, and some potent JH mimics have been used as insecticides. Recent studies on the enzymes in JH biosynthetic and metabolic pathways should be helpful for the discovery of more potent analogs and for the establishment of new means of pest management using recombinant DNA technology. © Pesticide Science Society of Japan Keywords: juvenile hormone (JH), insect metamorphosis, insect growth regulators, biosynthesis and metabolism of JH. Review* To whom correspondence should be addressed. E-mail: chieka_minakuchi@yahoo.com © Pesticide Science Society of Japan doptera. 17,18) Higher Diptera such as D. melanogaster and the blowfly Calliphora vomitoria produce JH III bisepoxide. 19,20) A small amount of methyl farnesoate, a precursor of JH III, was found in cockroach embryos and larvae. [20][21][22] Methyl farnesoate has also been identified in crustaceans 23) and is thought to have a JH-like action in female reproduction. 24)12Ј-OH JH III identified from the corpora allata of the African locust Locusta migratoria migratorioides was reported to exhibit JH activity when a high dose of this compound was topically applied to Tenebrio pupae. 25,26) Biosynthesis, Transport and Metabolism of Juvenile HormoneIn insects, JH is synthesized in the corpora allata via the mevalonate pathway (Fig. 2).27) The mevalonate pathway also exists in mammals and plants, and the early steps from acetylCoA to farnesyl diphosphate are conserved among these organisms. Importantly, insects and other arthropods do not synthesize cholesterol de novo but have to acquire it from dietary sources because they lack the genes encoding squalene synthase and other subsequent enzymes of the sterol branch. 28,29) Another peculiarity of the mevalonate pathway in insects is the capacity to synthesize JH via the isoprenoid branch.The genes encoding the enzymes in the mevalonate pathway from acetyl-CoA to farnesyl diphosphate have been identified in the genome of D. melanogaster and the malaria mosquito Anopheles gambiae, and in an EST library of the pine engraver Ips pini.27) However, it has been difficult to identify the genes encoding enzymes from farnesyl diphosphate to JH

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Section: Natural and Synthetic Jh Mimics As Insect Growth Regulatorsmentioning

confidence: 99%

Section: Natural and Synthetic Jh Mimics As Insect Growth Regulatorsmentioning

confidence: 99%

Insect juvenile hormone action as a potential target of pest management

Minakuchi

Riddiford

2006

J. Pestic. Sci.

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“…Although JH is a necessary molecule at certain time in insect development, it is toxic when present during early metamorphosis in certain insects, especially Diptera (Wilson, 2004). Several chemical companies have taken advantage of this characteristic and synthesized chemical analogs of JH (JHA) having insecticidal activity for certain insects (Staal, 1975;Mulla, 1995;Ritchie and Broadsmith, 1997). Perhaps the most successful JH analog is methoprene (isopropyl 11-methoxy-3, 7, 11-trimethyl-2, 4-dodecadienoate) (Henrick et al, 1973), which is very effective against dipteran insects (Staal, 1975;O'Donnell and Klowden, 1997).…”

Section: Introductionmentioning

confidence: 99%

Drosophila melanogaster Methoprene-tolerant (Met) gene homologs from three mosquito species: Members of PAS transcriptional factor family

Wang

Baumann

Wilson

2007

Journal of Insect Physiology

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The Methoprene-tolerant (Met) gene in Drosophila melanogaster has been shown to function in juvenile hormone (JH) action. Met homologs were isolated from three mosquito species, Culex pipiens, Aedes aegypti and Anopheles gambiae. Sequence similarity was found to be high in bHLH and PAS conserved domains, and the majority of the 7-9 introns in AaMet and AgMet are located in either identical or similar positions, indicating evolutionary relatedness. Sequence comparison with Met and the similar germ-cell expressed (gce) gene in D. melanogaster showed that the mosquito genes are more similar to gce than to Met. Moreover, the multiple introns in AgMet and AaMet are more similar in number with the 7 introns in Dmgce than to the single intron in DmMet; in fact, six intron positions in AaMet and AgMet are similar to those in Dmgce. Efforts to identify a second homologous gene in mosquitoes were unsuccessful, suggesting a single gene in lower Diptera, consistent with the single gene uncovered in genomic sequencing of Ae. aegypti and An. gambiae. These results suggest that a gene duplication occurred during the evolution of higher Diptera, resulting in Met and gce.

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“…The extract of C. aromaticus cultured cells might produce their effects on fecundity and hatchability in mosquito species through its influence on the endocrine system due to the JH III content. Both embryogenesis and embryonic ecdysis are inhibited in eggs of many insects species exposed to juvenile hormone active IGRs in the female body or after the egg deposition [46] . Prolongation of larval and pupal periods of insects following exposure to phytoextracts indicates the interference by the bio-active compounds on the normal hormonal activity coordination of the metabolic processes of the developing stages probably due to interference in the endocrine mechanism [47] .…”

Section: Discussionmentioning

confidence: 99%

Bioefficacy of crude extract of Cyperus aromaticus (Family: Cyperaceae) cultured cells, against Aedes aegypti and Aedes albopictus mosquitoes

Kamiabi

Jaal

Keng

2013

Asian Pacific Journal of Tropical Biomedicine

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Objective: To evaluate the growth inhibition activity of the crude extract of Cyperus aromaticus (C. aromaticus) cultured cells against the 3rd instar larvae of Aedes aegypti (Linn.) and Aedes albopictus Skuse (Ae. albopictus) under laboratory conditions, and determine the sublethal effects (EI 50 ) of the crude extract of C. aromaticus cultured cells on some biological and morphological parameters of both Aedes mosquito species during two generations as well. Methods: The cell suspension cultures of C. aromaticus were activated from five callus lines (P4, Pa, Z1, Z6 and Ml) derived from the root explants of in vitro plantlets. The cultured cells were extracted in chloroform and used as plant material for the present study. For detection of juvenile hormone III, the crude extracts were analyzed by HPLC. Then the crude extracts of the three C. aromaticus cultured cell lines which contained varied amounts of juvenile hormone III [high level (P4 cell line), medium level (Z1 cell line) and low level (Ml cell line)] were tested against Aedes mosquito species. Laboratory evaluation was performed against late third instar larvae of the Vector Control Research Unit strains of Ae. aegypti and Ae. albopictus using the standard WHO method. The effects of EI 50 of the C. aromaticus cultured P4 cells on fecundity, fertility, growth period, sex ratio, adult size and longevity of Aedes mosquitoes were assessed. Results: Bioassay tests presented the remarkable growth inhibition activity of the crude extracts of C. aromaticus cultured cells against the two Aedes mosquitoes. Between the two mosquito species, Ae. albopictus was more susceptible to the crude extracts with lower EI 50 values. EI 50 of the crude extract of C. aromaticus cultured cells (P4) increased the sterility indices in the parental generation females in both Aedes mosquito species. A significant delay in the pupal formation and adult emergence were observed in the parental generation of the both mosquito species. The sex ratio of the adult population either parental or F1 generation of the Aedes mosquito species was not significantly affected by the EI 50 dosage of the crude extract of C. aromaticus cultured P4 cells. A significant decrease in the wing length of the treated adult (female and male) of Aedes aegypti as well as the treated female of Ae. albopictus were observed. Longevity of the adult female of the parental generation of both Aedes mosquitoes as well as females of F1 generation of Ae. albopictus were significantly decreased. Conclusions: The present study revealed the potential of the crude extract of C. aromaticus cultured cells in controlling vector mosquito populations in the effort to reduce the transmission of vector borne diseases.

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Insect Growth Regulators with Juvenile Hormone Activity

Cited by 312 publications

References 87 publications

Insect juvenile hormone action as a potential target of pest management

Insect juvenile hormone action as a potential target of pest management

Drosophila melanogaster Methoprene-tolerant (Met) gene homologs from three mosquito species: Members of PAS transcriptional factor family

Bioefficacy of crude extract of Cyperus aromaticus (Family: Cyperaceae) cultured cells, against Aedes aegypti and Aedes albopictus mosquitoes

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