Insect Hormones (as Pesticides)

Subramanian, S.; Shankarganesh, K.

doi:10.1016/b978-0-12-803265-7.00020-8

Cited by 12 publications

(4 citation statements)

References 202 publications

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“…The role of 20E in inducing insect molting and metamorphosis is well-characterized [10,38]. E75 is an early regulated gene that is involved in many physiological processes within the insect ecdysone signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Functional Characterization of the Nuclear Receptor Gene SaE75 in the Grain Aphid, Sitobion avenae

Zheng

Yan

Wei

et al. 2023

Insects

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Ecdysteroid hormones are key regulators of insect development and metamorphosis. Ecdysone-inducible E75, a major component of insect ecdysone signaling pathway, has been well characterized in holometabolous insects, however, barely in hemimetabolous species. In this study, a total of four full-length E75 cDNAs from the English grain aphid, Sitobion avenae, were identified, cloned, and characterized. The four SaE75 cDNAs contained 3048, 2625, 2505, and 2179 bp open reading frames (ORF), encoding 1015, 874, 856, and 835 amino acids, respectively. Temporal expression profiles showed that SaE75 expression was low in adult stages, while high in pseudo embryo and nymphal stages. SaE75 was differentially expressed between winged and wingless morphs. RNAi-mediated suppression of SaE75 led to substantial biological impacts, including mortality and molting defects. As for the pleiotropic effects on downstream ecdysone pathway genes, SaHr3 (hormone receptor like in 46) was significantly up-regulated, while Sabr-c (broad-complex core protein gene) and Saftz-f1 (transcription factor 1) were significantly down-regulated. These combined results not only shed light on the regulatory role of E75 in the ecdysone signaling pathway, but also provide a potential novel target for the long-term sustainable management of S. avenae, a devastating global grain pest.

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Section: Discussionmentioning

confidence: 99%

Functional Characterization of the Nuclear Receptor Gene SaE75 in the Grain Aphid, Sitobion avenae

Zheng

Yan

Wei

et al. 2023

Insects

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“…It is possible to relate the insect's toxicity, morphological flaws, and histological malformations to the unique blend of constituents in ES2 metabolite; with cyromazine serving as a significant element. Cyromazine has long been used to control pests in agricultural crops and public health management systems (Subramanian and Shankarganesh 2016 ). It is has a molt inhibitor effect, since it interferes with cuticle production in the insect (Pener and Dhadialla 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Endophytic actinobacteria from wild medicinal plants are a natural source of insecticide to control the African cotton leafworm (Spodoptera littoralis)

et al. 2023

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Insecticide resistance in agricultural pests has prompted the need to discover novel compounds with new modes of action. We investigated the potency of secondary metabolites from seventy endophytic actinobacteria against laboratory and field strains of Spodoptera littoralis (fourth instar), comparable to the bioinsecticide spinetoram (Radiant SC 12%). Endophytes from Artemisia herba-alba and A. judaica were highly effective. Chemical profiling of the most potent metabolite of the strain Streptomyces sp. ES2 was investigated using LC-QTOF-MS-MS technique, and the activity was validated through molecular docking studies. Metabolic extracts from actinobacteria belonging to Streptomyces, Nocardioides, and Pseudonocardia showed immediate and latent death to the Spodoptera littoralis fourth instar larvae. The metabolite from strain ES2 has shown the most promising and significant histopathological and inhibitory effects on the fourth instar larvae. ES2 metabolite caused lesions in the body wall cuticle, indicating a different mode of action than that of Radiant. Chemical profiling of ES2 showed the presence of cyromazine (molt inhibitor), 4-nitrophenol, and diazinon as key constituents. In conclusion, these findings suggest that secondary metabolites from endophytic actinobacteria inhabiting wild medicinal plants can be a sustainable source for promising natural biocontrol agents. This is the first illustration of the insecticidal activity of Artemisia spp. microbiome, and natural cyromazine synthesis by actinobacteria.

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“…IGRs are attractive control measures due to their selective toxicity against insects and decreased rate of insecticide resistance developed against them relative to traditional pesticides 9,10 . IGR targets such as, JH and 20E and their receptors, are widely conserved in insects increasing the chances of negative effects on non-target species 7,8,[11][12][13] . An attractive alternative to IGRs that act on JH or 20E are compounds that selectively target hormones or hormone receptors that are not widely conserved across all insect groups.…”

Section: Introductionmentioning

confidence: 99%

RNAi-mediated knockdown of two orphan G-protein coupled receptors reduces fecundity in the yellow fever mosquitoAedes aegypti

Keyes-Scott

Swade

Allen

et al. 2023

Preprint

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G-protein coupled receptors (GPCRs) control numerous physiological processes in insects, including reproduction. While many GPCRs have known ligands, orphan GPCRs do not have identified ligands in which they bind. Advances in genomic sequencing and phylogenetics provide the ability to compare orphan receptor protein sequences to sequences of characterized GPCRs, and thus gain a better understanding of their potential function. Our study investigated two orphan GPCRs, AAEL003647 and AAEL019988, in the yellow fever mosquito,Aedes aegypti. From our phylogenetic analysis, we found that AAEL003647 is orthologous to the SIFamide-2/SMYamide receptor, while AAEL019988 is orthologous to the Trapped in endoderm (Tre1) receptor ofDrosophila melanogaster. Tissue-specific expression analysis revealed that both receptors had highest expression in the ovaries, suggesting they may be important for reproduction. We then used RNA interference (RNAi) to knock down both genes and found a significant reduction in the number of eggs laid per individual female mosquito, suggesting both receptors are important forAe. aegyptireproduction.

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Insect Hormones (as Pesticides)

Cited by 12 publications

References 202 publications

Functional Characterization of the Nuclear Receptor Gene SaE75 in the Grain Aphid, Sitobion avenae

Functional Characterization of the Nuclear Receptor Gene SaE75 in the Grain Aphid, Sitobion avenae

Endophytic actinobacteria from wild medicinal plants are a natural source of insecticide to control the African cotton leafworm (Spodoptera littoralis)

RNAi-mediated knockdown of two orphan G-protein coupled receptors reduces fecundity in the yellow fever mosquitoAedes aegypti

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