Insect Pest Resistance: An Alternative Approach for Crop Protection

Khan, Mohammad Zafar; Khan, Zakaullah; Ahmad, Wasim; Paul, Bishwajeet; Paul, Sangeeta; Aggarwal, Chetana; Akhtar, Mohd Sayeed

doi:10.1007/978-3-319-23162-4_11

Cited by 13 publications

(12 citation statements)

References 119 publications

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“…Utilizing in silico methods such as homology modeling, docking, and MD simulations, such molecules can be rapidly identified accelerating the emergence of more specific and environmentally friendly pesticides. However, lack of structural data on Pigment dispersing factor and vasoactive intestinal Essential for normal circadian function [139] Corazonin and GnRH Involved in adult metabolism and stress responses [140] insect GPCRs is a serious limiting factor that hinders the search for agonists and antagonists. High-throughput virtual screening is widely exploited in human GPCRs to identify better candidates for the available and approved drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Pesticide resistance possesses a growing challenge for sustainable crop protection and production, but also for the effective control of disease-borne vectors threatening human health [138,139]. Given that pathogen vectors have been evolving rapidly in response to the selective pressure exerted by over a century by insecticide use, novel chemicals must be developed to reduce the incidence of resistance.…”

Section: Opportunities Provided By Targeting Insect Gpcrs Providesmentioning

confidence: 99%

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Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

et al. 2021

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The increasing human population, combined with low inefficiency and adverse effects of available pesticides, has magnified the urgent need of developing next-generation pesticides. Among the available approaches, strategies targeting invertebrate G protein-coupled receptors (GPCRs) are very promising as these receptors are the targets of endogenous neuropeptides/neuromodulators that upon binding to their receptors induce profound changes in insect physiology. Therefore, exploring GPCR regulators has great potential in the development of targeted next-generation pesticides. Despite the great potential of such alternative pesticides, so far there has been only one approved compound, Amitraz, which conveys its antipest activity via the GPCR Octopamine receptor. Here, we review the current status of pesticide development, hazards associated with conventional pesticide compounds, alternative strategies that involve next-generation of pesticides, structural features of GPCRs, and opportunities and challenges of targeting the members of this superfamily in invertebrates to develop anti-pest agents. In conclusion, we emphasize that the potential of GPCRs cannot be utilized in full without more genomic and transcriptomic data to improve our understanding of the complex network of peptidergic signaling pathways. We argue how vital it is to obtain three-dimensional (3D) structural data on physiologically important target GPCRs and encourage the readers to use the state of the art in silico methods such as virtual screening for the discovery of new pesticide compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Opportunities Provided By Targeting Insect Gpcrs Providesmentioning

confidence: 99%

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

et al. 2021

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“…As suggested by Khan et al (2015), the frequent application of the same insecticide in one vegetative season or over a longer period of time causes the pest to develop a resistance to the given pesticide and accumulation of residues. The studies of residua problems associated with the application of chemicals from combined program (A2, B1, A2 and B2, B2, B2) in melon were performed using the QuEChERS/LC/MS/MS method described earlier (Łozowicka et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Biological and chemical protection of melon crops against Myiopardalis pardalina Bigot

et al. 2019

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The aim of this project was to explore the cycle of the pest's development and to evaluate the efficacy of insecticides from the pyrethroid, organophosphate and neonicotinoids groups in controlling Myiopardalis pardalina Bigot in melon plantations under the conditions of Southeast Asia. Three kinds of traps were tested (pheromone, stick and feeding) for monitoring quarantine flies. The application of thiamethoxam/cyhalothrin (A) and chlorpyrifos/cypermethrin (B) in variant A, B, A in dose 0,2; 0,5; 0,2 l/ha was more effective than threefold applications of chlorpyrifos/cypermethrin in variant B, B, B in dose 0,7; 0,7; 0,7 l/ha during the growing season. Among all traps used, the lowest degree of melon damage (8.8%) was noted only for the variant with 10 pheromone traps per hectare, where the crop yield of melon was slightly higher than in the case of the other traps (16.63 t/ha). The combination A, B, A improved the quality of fruit, decreased melon infestation with ovipositor marks and significantly reduced fly population up to 14 days. Only chlorpyrifos residues were determined in melon after harvesting at an acceptable level.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…Biological control agents are used to control environmental contamination of synthetic insecticides. Biological control agents (predators, parasitoids, and pathogens) target specific pests or introduce these organisms using inoculative techniques that might effectively reduce a pest's population [65]. Baculoviruses (Nucleopolyhedroviruses (NPV) and Granuloviruses (GV) are significant microbial agents used as biopesticides [66].…”

Section: Biological Controlmentioning

confidence: 99%

Mechanism of Insecticide Resistance in Insects/Pests

Khan¹,

Uddin²,

Rizwan³

et al. 2020

Pol. J. Environ. Stud.

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The main purpose of this study is to provide essential information regarding the molecular basis of insecticide resistance and to report candidate genes which are responsible for resistance in insects/pests. There are two basic resistance mechanisms existing in pests, i.e., target site resistance and metabolic resistance. During resistance of target site, the specific binding site of an insecticide is modified (mutated) and/or lost, which makes the target site incompatible for activation. Mutation occurs in most common pest (Myzus persicae, Musca domestica and Drosophila melanogaster) target regions, i.e., subunits like nicotinic acetylene choline receptors (nAChRs), knock-down resistance (KDR) etc. Due to these mutations, insecticides are unable to bind into the target region, resulting in loss of binding affinity. Furthermore, in metabolic resistance over production of enzymes occurs which break down (detoxify) insecticides and resulting resistance of pests. The amplification of metabolic enzymes, i.e., Cytochromes p450 monooxygenase, hydrolyses, and Glutathione S-transferase play a central role in evolving metabolic resistance. Various successful approaches are used to combat pests resistance such as insecticides, bio-pesticides and biological control agents. However, some of these strategies have certain limitations such as contamination of the environment, while others possess a low capacity in management of pests. Recent studies have highlighted some novel mechanisms of insecticide resistance that are part of the ongoing efforts to define the molecular basis of insecticide resistance in insect species.

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Insect Pest Resistance: An Alternative Approach for Crop Protection

Cited by 13 publications

References 119 publications

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

Biological and chemical protection of melon crops against Myiopardalis pardalina Bigot

Mechanism of Insecticide Resistance in Insects/Pests

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