Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E; Cordova, Daniel

doi:10.1016/j.bmcl.2005.08.034

Cited by 408 publications

(121 citation statements)

References 13 publications

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“…Chlorantraniliprole is a novel anthranilic diamide insecticide discovered by DuPont, also known as Rynaxypyr and DPX-E2Y45, which belongs to a new chemical class of selective ryanodine receptor (RyR) agonists (Lahm et al, 2005;Cordova et al, 2006). Upon ingestion, chlorantraniliprole activates the release and depletion of internal calcium stores in muscles (Bassi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Toxicity and Efficacy of Chlorantraniliprole on Pieris rapae (Linnaeus) (Lepidoptera: Pieridae) on Cabbage

Su¹,

Hong²,

Cheng³

et al. 2017

JAS

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Toxicity of chlorantraniliprole was assayed against young (first and second instars) and older larvae (third and fourth instars) of cabbage Pieris rapae (Lepidoptera: Pieridae) on cabbage (Brassicae oleracea), and persistence of field-aged leaf residue of chlorantraniliprole was assayed with 5-old-day larvae of P. rapae on cabbage. Efficacies of chlorantraniliprole and other newer insecticides to P. rapae were tested under field conditions for two seasons in Hubei province in China. The LC 50 value of chlorantraniliprole for early and later P. rapae larvae were 7.92 and 11.34 mg/L by contact toxicity, respectively. The LC 50 value of chlorantraniliprole for early and later P. rapae larvae were 0.95 and 4.32 mg/L through ingestion, respectively. The toxicity of field-aged leaf residues of chlorantraniliprole (0-, 3-, 5-, 7-, 10-, 14-, 21-, 25-, and 28-day-old residues) declined gradually under the field conditions. Almost all larvae died on day 5 after feeding on the leaves with 0-21-day residue, and the mortalities were as high as 83.3% and 72.5% for the 21-and 25-day-old leaf residues. Chlorantraniliprole application suppressed P. rapae larvae below the economic threshold for 21-28 days. The field efficacy trials show that chlorantraniliprole at 52 mg a.i /L rate was effective against P. rapae larvae on cabbage, providing marketable cabbage with three applications per season. In addition, chlorantraniliprole was as effective as indoxacarb and spinosad and significantly more effective than emamectin benzoate.

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Section: Introductionmentioning

confidence: 99%

Toxicity and Efficacy of Chlorantraniliprole on Pieris rapae (Linnaeus) (Lepidoptera: Pieridae) on Cabbage

Su¹,

Hong²,

Cheng³

et al. 2017

JAS

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“…[21][22][23] The present study demonstrated that Ca 2ϩ pump stimulation, a result of disrupting intracellular calcium kinetics caused by functional modulation of the RyR, is closely correlated to insecticidal activities of the compounds. The results of this study can provide technical bases for a new assay method to screen insecticides targeting intracellular Ca 2ϩ kinetics, a new promising target for selective insecticides.…”

Section: Discussionmentioning

confidence: 89%

Quantitative relationship between insecticidal activity and Ca2+ pump stimulation by flubendiamide and its related compounds

et al. 2009

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“…Flubendiamide is an inhibitor of ryanodine receptor that was developed by the Japanese Pesticide Corporation, Ltd. and first registered in the Philippines in 2007 [1] [2]. Flubendiamide is mainly effective for controlling lepidopteron pests, including resistant strains in vegetables, fruits, rice, and cotton.…”

Section: Introductionmentioning

confidence: 99%

“…Flubendiamide is a new phthalic amide insecticide that has a function in the activation mechanism of intracellular calcium release channels (ryanodine receptors), a leading cause of uncontrolled storage of calcium release. Given the uniqueness of this mechanism, no cross-resistance to conventional insecticides has been found, and it is safe for arthropods and mammals [1] [3]- [6]. The 20% flubendiamide water dispersible granule (WDG) is registered for controlling vegetable insects, such as Spodoptera exigua or Plutella xylostella, in China.…”

Section: Introductionmentioning

confidence: 99%

Degradation Dynamics and Residue Analysis of Flubendiamide in Cabbage and Soil by Liquid Chromatography-Tandem Mass Spectrometry with Dispersive Solid Phase Extraction

Chen¹,

Wang²,

Meng³

et al. 2014

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Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

Cited by 408 publications

References 13 publications

Toxicity and Efficacy of Chlorantraniliprole on Pieris rapae (Linnaeus) (Lepidoptera: Pieridae) on Cabbage

Toxicity and Efficacy of Chlorantraniliprole on Pieris rapae (Linnaeus) (Lepidoptera: Pieridae) on Cabbage

Quantitative relationship between insecticidal activity and Ca2+ pump stimulation by flubendiamide and its related compounds

Degradation Dynamics and Residue Analysis of Flubendiamide in Cabbage and Soil by Liquid Chromatography-Tandem Mass Spectrometry with Dispersive Solid Phase Extraction

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