Insecticidal Anthranilic Diamides: A New Class of Potent Ryanodine Receptor Activators.

Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E; Cordova, Daniel

doi:10.1002/chin.200606148

Cited by 113 publications

(167 citation statements)

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“…Chlorantraniliprole is an anthranilic diamide insecticide, which displays exceptional insecticidal activity on a broad range of insects pests belonging to Lepidoptera, Coleoptera, Diptera and Hemiptera in various agricultural, residential, commercial, and public landscaped areas (Sattelle etal., 2008;Lahm et al, 2009;Dinter, 2009).Anthranilic diamides selectively bind to ryanodine receptors in insect muscles resulting in an uncontrolled release of calcium from internal stores in the sarcoplasmic reticulum, causing impaired regulation of muscle contraction leading to feeding cessation, lethargy, paralysis, and death of target organisms (Lahm et al, 2005;Cordova et al, 2006).Chlorantraniliprole shows very low acute toxicity to birds when given orally or applied to the diet. Anas platyrhynchos (Mallard) and Colinus virginianus (Northern bobwhite) show no toxic effects orally and Anas platyrhynchos show viable embryo reduction while egg shell thinning was reported in Colinus virginianus (U.S. EPA, 2008;Kraggerud et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus)

Abbas

Iqbal

Butt

et al. 2017

IJAR

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The present study was designed to assess the teratogenic effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus). Different doses of commercial Chlorantraniliprole (0.1, 0.5, 1.0 and 1.5µl/1000µl/egg, in four experimental groups B, C, D, and E respectively) were injected into the yolk sac of eggs before incubation. Embryos were recovered at day 12 of incubation. The mortality rate gradually increased from lower to higher doses. A total of twelve morphometric parameters viz., wet body weight, crown rump length, anterior posterior head diameter, eye diameter, beak length, neck length, humor length, radius and ulna length, metacarpus length, femur length, fibula length and metatarsus length were recorded and compared with control group. These quantitative parameters indicated significant (p<0.05) decreases in all treated groups compared to control group. While the qualitative anomalies such as microcephaly, hydrocephaly, edematous swelling, hematoma formation, abnormal body coloration, microphthalmia, deformed beak, agnathia, micromelia, amelia, omphalocele and ectopia cardis were also observed in treated groups as compared to untreated groups. Therefore it is concluded that Chlorantraniliprole has potentially harmful effects on the development of avian embryos even at very low dose concentration. Hence, due to toxicity of this pesticide it can be used with utmost caution.

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Section: Introductionmentioning

confidence: 99%

Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus)

Abbas

Iqbal

Butt

et al. 2017

IJAR

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“…Chlorantraniliprole is currently classified as a 'reduced-risk pesticide' by the Evironmental Protection Agency (EPA, 2008). The compound is an anthranilic diamide, and exhibits a novel mode of action in which insect ryanodine receptors are activated, resulting in rapid paralytic muscle dysfunction (Hannig et al 2009, Cordova et al 2006, Lahm et al 2005. Regulation of the release of internal cell calcium is affected by activation of ryanodine receptors.…”

Section: Introductionmentioning

confidence: 99%

Performance of Altriset (TM) (Chlorantraniliprole) Termiticide Against Formosan Subterranean Termites, Coptotermes formosanus Shiraki, in Laboratory Feeding Cessation and Collateral Transfer Trials, and Field Applications

2015

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Chlorantraniliprole represents the first compound to be registered as a termiticide by the Environmental Protection Agency (EPA) in over a decade. This novel termiticide is currently registered as a 'reduced-risk pesticide' by the EPA. Laboratory and field trials were conducted to quantify mortality of Formosan subterranean termites (FST), Coptotermes formosanus Shiraki resulting from chlorantraniliprole treated soil, the degree to which the termites curtail feeding intensity post-exposure to chlorantraniliprole treated soil, collateral transfer of chlorantraniliprole among nest mates, and the effectiveness of chlorantraniliprole as a remedial treatment against structural infestations of FST. Termites which were exposed to chlorantraniliprole treated soil consumed significantly less paper than unexposed FST. The mean percent mortality of those termites exposed to chlorantraniliprole treated soil was significantly greater than that of unexposed FST. Depending on donor:recipient ratios, the mean mortality of recipients ranged from 14.65 -90.00 % in the collateral transfer trials. There was a positive correlation between increased donor density and recipient mortality. Through 24 mo post-treatment, 27.3% of the structures which were treated in field trials were observed to have infestations of termites that required re-treatment; however, no FST were observed during the 30 and 36 month post-treatment inspections. Additionally, a novel scoring rubric was developed that will allow standardization of field study sites with respect to dissimilarity in site variables, and will allow for more consistent comparison of results across disparate field experiments. An explanation for Vol. 59, No. 2, 2012 the lack of successful remediation of many of the structures involved in the field trial is proposed and is based on our novel scoring system.

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“…In order to protect the food supply and combat against insects resistance, the discovery of eco-friendly and effective insecticides with new mode of action is highly critical in agrochemcial research [1][2]. The ryanodine receptor (RyR) within insects is a non-voltage gated calcium channel, which is located in the sarcoplasmic reticulum and regulates the release of intracellular calcium stores critical for muscle contraction [2][3][4].…”

mentioning

confidence: 99%

“…The ryanodine receptor (RyR) within insects is a non-voltage gated calcium channel, which is located in the sarcoplasmic reticulum and regulates the release of intracellular calcium stores critical for muscle contraction [2][3][4]. Up to date, there are three commercial products namely Flubendiamide [5], ( Figure 1A ), Chloranthraniliprole (B) and Cyantranidliprole (C) [6][7], all of which have highly potent effects on insect RyRs.…”

mentioning

confidence: 99%

The Study of Novel Sulfilimines as Potential Insects Modulators

Li¹

2014

J Phys Chem Biophys

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Insecticidal Anthranilic Diamides: A New Class of Potent Ryanodine Receptor Activators.

Cited by 113 publications

References 1 publication

Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus)

Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus)

Performance of Altriset (TM) (Chlorantraniliprole) Termiticide Against Formosan Subterranean Termites, Coptotermes formosanus Shiraki, in Laboratory Feeding Cessation and Collateral Transfer Trials, and Field Applications

The Study of Novel Sulfilimines as Potential Insects Modulators

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