Insecticidal meliacarpins (C-seco limonoids) from Melia azedarach

Bohnenstengel, Frank; Wray, Victor; Witte, Ludger; Srivastava, R. P.; Proksch, Peter

doi:10.1016/s0031-9422(98)00644-x

Cited by 52 publications

(38 citation statements)

References 6 publications

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“…Azedarachol (NAKATANI et al, 1985) Trichilins, azedarachins (NAKATANI et al, 1995) Meliacarpins (BOHNENSTENGEL et al, 1999 . C. incisa and C. microcephala had insignificant action against larvae.…”

Section: In Vitro Testsmentioning

confidence: 99%

Perspectives for the use of plant extracts to control the cattle tick Rhipicephalus (Boophilus) microplus

Borges

Sousa

Barbosa

2011

Rev. Bras. Parasitol. Vet.

113

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The evolution of resistance of Rhipicephalus (Boophilus) microplus to synthetic acaricides has given rise to the need for new scientific investigations on alternative ways to control this tick. In this regard, various studies on plants have been developed in an attempt to find extracts with acaricidal properties. Evaluations on plant extracts for controlling R. (B.) microplus have grown intensely over the last decade. There are many advantages from using plant extracts: for example, they can be used in organic cattle farming or even replace synthetic acaricides and they are associated with lower environmental and food contamination, slower development of resistance and lower toxicity to animals and humans. In vitro studies on plant extracts have shown promising results, but most of these extracts have not been tested on animals to validate their use. Difficulties in preparing proper formulations, differences in the chemical composition of plants of the same species due to extrinsic and intrinsic factors and sparse information on active acaricide compounds are hindrances that need to be addressed in order to enable progress within this scientific field.Keywords: Phytotherapy, cattle tick, Rhipicephalus (Boophilus) microplus, in vitro bioassays, in vivo bioassays. ResumoA evolução da resistência do Rhipicephalus (Boophilus) microplus aos acaricidas sintéticos tem impulsionado novas investigações científicas sobre métodos alternativos para controlar este carrapato. Considerando isso, vários estudos com plantas têm sido desenvolvidos numa tentativa de encontrar extratos com propriedades acaricidas. Avalições de extratos de plantas para o controle de R. (B.) microplus tem sido intensificadas nesta última década. Existem muitas vantagens com o uso de extratos de plantas no controle deste carrapato, como: eles podem ser utilizados na produção orgânica de bovinos, ou mesmo substituir os acaricidas sintéticos, além do mais, estão associados com baixa contaminação ambiental e dos alimentos, desenvolvimento mais lento de resistência e baixa toxicidade para animais e seres humanos. Estudos in vitro de extratos de plantas têm apresentado resultados promissores, mas a maioria destes extratos não têm sido testada em animais para validar estes resultados. Dificuldades para preparar formulações apropriadas, diferenças na composição química de plantas de uma mesma espécie devido a fatores intrínsecos e extrínsecos e informações esparsas.sobre os princípios ativos são entraves que precisam ser solucionados visando o desenvolvimento deste campo de pesquisa.Palavras-chave: Fitoterapia, carrapato de bovinos, Rhipicephalus (Boophilus) microplus, testes in vitro, testes in vivo.

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Section: In Vitro Testsmentioning

confidence: 99%

Perspectives for the use of plant extracts to control the cattle tick Rhipicephalus (Boophilus) microplus

Borges

Sousa

Barbosa

2011

Rev. Bras. Parasitol. Vet.

113

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“…Breuer et al (2003) found a decrease of 31% in the activity of C cholinesterase in S. frugiperda, when the extract of M. azedarach (0.01%) was mixed in the artificial diet. Similarly, three new meliacarpin compounds from of the leaves against S. litorallis (Boisduval, 1833) (Lepidoptera: Noctuidae), showed a LC 50 of 2.36; 1.19, and 0.48 ppm for the compounds 1, 2, and 3, respectively, when compared with 0.32 ppm for azadiractin (Bohnenstengel et al 1999). The mortality of S. frugiperda was due to the compounds such as meliacarpin and its byproducts aqueous extract from M. azedarach.…”

Section: Resultsmentioning

confidence: 99%

“…For example, M. azedarach (Meliaceae), or Chinaberry has insecticidal properties (Huang et al 1996, Ventura andIto, 2000;Brunherotto and Vendramim 2001) due to various compounds, such as salanalin, meliaterin, and meliacarpinin. Some other compounds from this plant have insecticidal activity against beetles (Curculionidae, Tenebrionidae, and Chrysomelidae), as well as Lepidoptera (Huang et al 1996;Bohnenstengel et al 1999;Carpinella et al 2003;Charleston et al 2006;Nathan 2006). The objective of this study was to assess the toxicity using in vivo assays of two new isolates of B. thuringiensis Cry proteins and an aqueous extract of M. azedarach as possible control agents for the rice pests O. oryzae and S. frugiperda.…”

Section: Introductionmentioning

confidence: 99%

Mortality of Oryzophagus oryzae (Costa Lima, 1936) (Coleoptera: Curculionidae) and Spodoptera frugiperda (J E Smith, 1797) (Lepidoptera: Noctuidae) Larvae Exposed to Bacillus thuringiensis and Extracts of Melia azedarach

Berlitz

Azambuja

Sebben

et al. 2012

Braz. arch. biol. technol.

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“…Various compounds isolated from M. azedarach have induced lethality on Spodoptera (Bohnenstengel et al 1999;Li et al 2012). It was also reported that Melia azedarach extract exhibits activity on NADPHcytochrome c reductase and cholinesterase of Spodoptera frugiperda (Breuer et al 2003).…”

Section: Introductionmentioning

confidence: 97%

“…Limonoids activity against Spodoptera is well documented in terms of antifeedant activity and growth regulation (Bohnenstengel et al 1999;Carpinella et al 2002;Farag et al 2011;Bullangpoti et al 2012). Various compounds isolated from M. azedarach have induced lethality on Spodoptera (Bohnenstengel et al 1999;Li et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Biological activity of Melia azedarach extracts against Spodoptera exigua

et al. 2014

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Melia azedarach is a plant species whose fruits posses nematicidal and insecticidal activity. In this study, we tested two M. azedarach extracts: a crude methanolic fruit extract (CRU) and its limonoids fraction (LIM) produced after partitioning with dichloromethane to check their insecticidal activity against beet armyworm Spodoptera exigua. Both extracts disturbed development of S. exigua. After exposure to CRU and LIM, hatching success was slightly lower, larvalpupal and pupal-imago moulting was significantly disturbed. In physiological studies, CRU extracts decreased the heartbeat of S. exigua pupae. Electron microscopic studies revealed that both extracts caused malformations of fat body and midgut cells. The most common observed malformations were: vacuolization of mitochondria, swollen endoplasmic reticulum and degeneration of nuclei. Obtained results indicated that M. azedarach fruits are a source of substances that may be used in plant protection against S. exigua. Despite the fact that M. azedarach extracts do not cause acute effects, their usage may lead to serious disturbances within exposed insects and significantly decrease activity of pests.

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Insecticidal meliacarpins (C-seco limonoids) from Melia azedarach

Cited by 52 publications

References 6 publications

Perspectives for the use of plant extracts to control the cattle tick Rhipicephalus (Boophilus) microplus

Perspectives for the use of plant extracts to control the cattle tick Rhipicephalus (Boophilus) microplus

Mortality of Oryzophagus oryzae (Costa Lima, 1936) (Coleoptera: Curculionidae) and Spodoptera frugiperda (J E Smith, 1797) (Lepidoptera: Noctuidae) Larvae Exposed to Bacillus thuringiensis and Extracts of Melia azedarach

Biological activity of Melia azedarach extracts against Spodoptera exigua

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