Insecticidal rocaglamide derivatives from Aglaia elliptica and A. harmsiana

Plant Natural Products as a Source for Developing Environmentally Acceptable Insecticides

“…There is a decline in insecticidal activity for rocaglamide derivatives featuring an unsubstituted C-2 in contrast with analogues possessing an amide or carboxylic substituent at this position. A similar trend has been noted in other rocaglamide derivatives isolated from A. odorata Gussregan et al 1997), and A. elliptica (Nugroho et al 1997b). Substitution of a hydroxy group with the methoxy group at C-8b resulted in a complete loss of activity in compounds that were isolated from roots of A. duperreana (Chaidir et al 1999) showing the importance of the OH group at C-8b.…”

“…Rocaglamide derivatives are unusual aromatic compounds featuring a cyclopentatetrahydrobenzofuran skeleton and are strictly confined to members of Aglaia. Recently, several novel rocaglamide derivatives, isolated from different Aglaia species have been shown to have strong insecticidal activity (in some cases even comparable to azadirachtin), mostly against neonate larvae of Spodoptera littoralis, Ostrinia species and the gram pod borer, Helicoverpa armigera (Brader et al 1998;Nugroho et al 1997aNugroho et al , 1997bNugroho et al , 1999Gussregan et al 1999;Koul et al 2004). The insecticidal mode-of-action as well as the potential anit-cancer activity of rocaglamides results from inhibition of protein synthesis, explaining the long time-to-death in treated insects .…”

Diamide Derivatives and Cycloartanes from the Leaves of Aglaia elliptica.

“…Several novel amides containing a cyclopenta-[bc]benzopyran moiety (ϭaglain-type) and a cyclopenta- [b]benzofuran moiety (ϭrocaglamide-type) as the acid part have been characterized from this genus, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] some of which were shown to exhibit cytotoxic 1,3,5,7,10,19,20) insecticidal, 2,6,8,9,[11][12][13][14][15]17) and antifungal 4) activities. In our series of studies of this genus, 16) we have investigated the constituents of the leaves of Aglaia elliptica Bl.…”

“…In our series of studies of this genus, 16) we have investigated the constituents of the leaves of Aglaia elliptica Bl. Rocaglamide derivatives from the fruits 9) and rocaglamide derivatives and dammaranes from the stems and fruits of this plant 10) have already been characterized. However, to our knowledge there have been no phytochemical reports on the leaves.…”

Development of a pharmacodynamic screening model with Crithidia fasciculata

“…Together with typical bisamides, flavaglines in particular represent a distinct phytochemistry restricted to the genus Aglaia. They are responsible for pronounced insecticidal activity in many arthropod species [25,26].…”