Insecticide and Viral Interaction as a Cause of Fatty Visceral Changes and Encephalopathy in the Mouse

Crocker, John F. S.; Ozere, R. L.; Rozee, K. R.; Digout, S. C.; Hutzinger, O.

doi:10.1016/s0140-6736(74)91351-8

Cited by 72 publications

(16 citation statements)

References 15 publications

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“…This may lead to a more permeable intestine that permits the passage of macromolecules and antigens that cause immune-mediated pathologic changes in the host. A more severe encephalomyocarditis virus infection has been noted in mice pre-treated with pesticide mixtures (DDT, fenitrothion) (Crocker et al, 1974). However, studies on encephalomyocarditis and influenza in mice indicate that emulsifiers, acting as surfactants for chemicals ordinarily not water soluble, used in pesticide preparations may enhance virus induced lethality (Crocker et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Interactions Among Infections, Nutrients and Xenobiotics

Ilbäck

Friman

2007

Critical Reviews in Food Science and Nutrition

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During recent years there have been several incidents in which symptoms of disease have been linked to consumption of food contaminated by chemical substances (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD). Furthermore, outbreaks of infections in food-producing animals have attracted major attention regarding the safety of consumers, e.g., Bovine Spongiform Encephalitis (BSE) and influenza in chicken. As shown for several xenobiotics in an increasing number of experimental studies, even low-dose xenobiotic exposure may impair immune function over time, as well as microorganism virulence, resulting in more severe infectious diseases and associated complications. Moreover, during ongoing infection, xenobiotic uptake and distribution are often changed resulting in increased toxic insult to the host. The interactions among infectious agents, nutrients, and xenobiotics have thus become a developing concern and new avenue of research in food toxicology as well as in food-borne diseases. From a health perspective, in the risk assessment of xenobiotics in our food and environment, synergistic effects among microorganisms, nutrients, and xenobiotics will have to be considered. Otherwise, such effects may gradually change the disease panorama in society.

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Section: Discussionmentioning

confidence: 99%

Interactions Among Infections, Nutrients and Xenobiotics

Ilbäck

Friman

2007

Critical Reviews in Food Science and Nutrition

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“…A more severe EMCV infection has been noted in mice pre-treated with pesticides (Crocker et al, 1986) and pesticide mixtures (DDT, fenitrothion) have been shown to potentiate infection-induced (EMCV) fatty changes in the liver and kidneys, as well as mortality (Crocker et al, 1974). However, subsequent studies on EMC and influenza B in mice indicate that the emulsifier used in pesticide preparations were mainly responsible for the enhancement of virus lethality (Crocker et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Interactions between Infections, Nutrients and Xenobiotics

2005

TemaNord

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“…Several other animal models for Reye's syndrome have been proposed (2)(3)(4)(5). The One most closely related to the octanoate model is produced by injection of 4-pentenoic acid into rats (5).…”

Section: Discussionmentioning

confidence: 99%

Pathologic Changes in a Rabbit Model of Reye's Syndrome

Trauner

1982

Pediatr Res

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Insecticide and Viral Interaction as a Cause of Fatty Visceral Changes and Encephalopathy in the Mouse

Cited by 72 publications

References 15 publications

Interactions Among Infections, Nutrients and Xenobiotics

Interactions Among Infections, Nutrients and Xenobiotics

Interactions between Infections, Nutrients and Xenobiotics

Pathologic Changes in a Rabbit Model of Reye's Syndrome

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