Insecticide resistance mechanisms in Anopheles gambiae complex populations from Burkina Faso, West Africa

Namountougou, Moussa; Soma, Dieudonné Diloma; Kientega, Mahamadi; Balboné, Mahamoudou; Kabore, Didier P.A.; Drabo, Samuel Fogné; Coulibaly, Abou; Fournet, Florence; Baldet, Thierry; Diabaté, Abdoulaye; Dabiré, Roch K.; Gnankiné, Olivier

doi:10.1016/j.actatropica.2019.105054

Cited by 37 publications

(30 citation statements)

References 42 publications

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“…Our results are consistent with that of a recent investigation conducted in an area of southwest Burkina Faso in 2016 (Namountougou et al 2019). But, compared with data collected pre-2010, this study suggests that the prevalence of pyrethroids resistance have increased considerably over time (Dabiré et al 2009, Badolo et al 2012.…”

Section: Discussionsupporting

confidence: 92%

“…Many mechanisms might be involved in this multiple resistance. Indeed, both L1014F and L1014S kdr mutations that confer cross-resistance to organochlorine and pyrethroids were recorded in a neighboring population from Diébougou (Namountougou et al 2019). The same authors also describe the presence at low frequency of the ace-1 mutation that confer crossresistance to both carbamates and organophosphorous and evidenced the presence of metabolic resistance mechanisms (esterase and GST) that may confer resistance to all tested families of insecticides (WHO 2018b).…”

Section: Discussionmentioning

confidence: 97%

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Insecticide resistance status of malaria vectorsAnopheles gambiae s.lof southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

Soma

Zogo

Hien

et al. 2020

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The rapid spread of insecticide resistance in malaria vectors and the rebound in malaria cases observed recently in some endemic areas underscore the urgent need to evaluate and deploy new effective control interventions. A randomized control trial was conducted with the aim to investigate the benefit of deploying complementary strategies, including indoor residual spraying (IRS) with pirimiphos-methyl, in addition to long-lasting insecticidal nets (LLINs) in Diébougou, southwest Burkina Faso. We measured the susceptibility of Anopheles gambiae s.l. population from Diébougou to conventional insecticides. We further monitored the efficacy and residual activity of pirimiphos-methyl on both cement and mud walls using a laboratory susceptible strain (Kisumu) and the local An. gambiae s.l. population. An. Gambiae s.l. from Diébougou was resistant to pyrethroids (deltamethrin, permethrin and alphacypermethrin) and bendiocarb but showed susceptibility to organophosphates (pirimiphos-methyl and chlorpyrimiphos-methyl). A mixed-effect generalized linear model predicted that pirimiphos-methyl applied on cement or mud walls was effective for 210 days against the laboratory susceptible strain and 247 days against the local population. The residual efficacy of pirimiphos-methyl against the local population on walls made of mud was similar to that of cement (OR=0.792, [0.55-1.12], Tukey’s test p-value =0.19). This study showed that one round of IRS with pirimiphos-methyl CS has the potential to control the multi-resistant An. gambiae s.l. population from Southwest Burkina Faso for at least 7 months, regardless of the type of wall.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Insecticide resistance status of malaria vectorsAnopheles gambiae s.lof southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

Soma

Zogo

Hien

et al. 2020

Preprint

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“…gambiae and An. funestus was observed [37,38], emphasizing the importance of AChE as a crucial target for malaria vector control strategies.…”

Section: Metabolic Proteins As Insecticide Targetsmentioning

confidence: 99%

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

et al. 2020

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The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles. Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins. This review aims to elucidate the current and potential contribution of Anopheles metabolic proteins to malaria transmission and control. Highlighted are the roles of metabolic proteins as insecticide targets, in blood digestion and immune response as well as their contribution to insecticide resistance and Plasmodium parasite development. Furthermore, strategies by which these metabolic proteins can be utilized for vector control are described. Inhibitors of Anopheles metabolic proteins that are designed based on target specificity can yield insecticides with no significant toxicity to non-target species. These metabolic modulators combined with each other or with synergists, sterilants, and transmission-blocking agents in a single product, can yield potent malaria intervention strategies. These combinations can provide multiple means of controlling the vector. Also, they can help to slow down the development of insecticide resistance. Moreover, some metabolic proteins can be modulated for mosquito population replacement or suppression strategies, which will significantly help to curb malaria transmission.

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“…aegypti adults issued from field collections (F0) (not previously exposed to insecticides and stored at −80 • C) using standard protocol [15]. Experimental procedures are detailed in Namountougou et al [16,17].…”

Section: Enzyme Activitiesmentioning

confidence: 99%

Monitoring Insecticide Susceptibility in Aedes Aegypti Populations from the Two Biggest Cities, Ouagadougou and Bobo-Dioulasso, in Burkina Faso: Implication of Metabolic Resistance

et al. 2020

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In West Africa, Aedes aegypti remains the major vector of dengue virus. Since 2013, dengue fever has been reemerging in Burkina Faso with annual outbreaks, thus becoming a major public health problem. Its control relies on vector control, which is unfortunately facing the problem of insecticide resistance. At the time of this study, although data on phenotypic resistance were available, information related to the metabolic resistance in Aedes populations from Burkina Faso remained very scarce. Here, we assessed the phenotypic and the metabolic resistance of Ae. aegypti populations sampled from the two main urban areas (Ouagadougou and Bobo-Dioulasso) of Burkina Faso. Insecticide susceptibility bioassays to chlorpyriphos-methyl 0.4%, bendiocarb 0.1% and deltamethrin 0.05% were performed on natural populations of Ae. aegypti using the WHO protocol. The activity of enzymes involved in the rapid detoxification of insecticides, especially non-specific esterases, oxidases (cytochrome P450) and glutathione-S-transferases, was measured on individual mosquitos. The mortality rates for deltamethrin 0.05% were low and ranged from 20.72% to 89.62% in the Bobo-Dioulasso and Ouagadougou sites, respectively. When bendiocarb 0.1% was tested, the mortality rates ranged from 7.73% to 71.23%. Interestingly, in the two urban areas, mosquitoes were found to be fully susceptible to chlorpyriphos-methyl 0.4%. Elevated activity of non-specific esterases and glutathione-S-transferases was reported, suggesting multiple resistance mechanisms involved in Ae. aegypti populations from Bobo-Dioulasso and Ouagadougou (including cytochrome P450). This update to the insecticide resistance status within Ae. aegypti populations in the two biggest cities is important to better plan dengue vectors control in the country and provides valuable information for improving vector control strategies in Burkina Faso, West Africa.

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Insecticide resistance mechanisms in Anopheles gambiae complex populations from Burkina Faso, West Africa

Cited by 37 publications

References 42 publications

Insecticide resistance status of malaria vectorsAnopheles gambiae s.lof southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

Insecticide resistance status of malaria vectorsAnopheles gambiae s.lof southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

Monitoring Insecticide Susceptibility in Aedes Aegypti Populations from the Two Biggest Cities, Ouagadougou and Bobo-Dioulasso, in Burkina Faso: Implication of Metabolic Resistance

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