Insecticides, biologics and nematicides: Updates to IRAC’s mode of action classification - a tool for resistance management

Sparks, Thomas C.; Crossthwaite, Andrew J.; Nauen, Ralf; Banba, Shinichi; Cordova, Daniel; Earley, Fergus G.P.; Ebbinghaus‐Kintscher, Ulrich; Fujioka, Shinsuke; Hirao, Ayako; Karmon, Danny; Kennedy, Robert M.; Nakao, Toshifumi; Popham, Holly J.R.; Salgado, Vincent L.; Watson, Gerald B.; Wedel, Barbara J.; Wessels, Frank J.

doi:10.1016/j.pestbp.2020.104587

Cited by 301 publications

(268 citation statements)

References 22 publications

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“…The indiscriminate use of pesticides has caused a negative impact in the environment and in the health of consumers. Besides, it has facilitated the emergence of resistance in more than 600 insect and mite species [73,74]. Those phenomena have driven the study of new insecticidal molecules that, ideally, are environment-friendly and affect the target pest species without harming beneficial insects, humans and other animals [75].…”

Section: Entomotoxic Effectsmentioning

confidence: 99%

“…Those phenomena have driven the study of new insecticidal molecules that, ideally, are environment-friendly and affect the target pest species without harming beneficial insects, humans and other animals [75]. According to the Insecticide Resistance Action Committee (IRAC), there are more than thirty types of modes of action currently described, including sodium channel modulators, juvenile hormone inhibitors and miscellaneous non-specific (multi-site) inhibitors, among others [73]. In the cases of Jaburetox and Soyuretox, their mechanism of action is still not completely understood.…”

Section: Entomotoxic Effectsmentioning

confidence: 99%

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Structure-Function Insights of Jaburetox and Soyuretox: Novel Intrinsically Disordered Polypeptides Derived from Plant Ureases

et al. 2020

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Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) do not have a stable 3D structure but still have important biological activities. Jaburetox is a recombinant peptide derived from the jack bean (Canavalia ensiformis) urease and presents entomotoxic and antimicrobial actions. The structure of Jaburetox was elucidated using nuclear magnetic resonance which reveals it is an IDP with small amounts of secondary structure. Different approaches have demonstrated that Jaburetox acquires certain folding upon interaction with lipid membranes, a characteristic commonly found in other IDPs and usually important for their biological functions. Soyuretox, a recombinant peptide derived from the soybean (Glycine max) ubiquitous urease and homologous to Jaburetox, was also characterized for its biological activities and structural properties. Soyuretox is also an IDP, presenting more secondary structure in comparison with Jaburetox and similar entomotoxic and fungitoxic effects. Moreover, Soyuretox was found to be nontoxic to zebra fish, while Jaburetox was innocuous to mice and rats. This profile of toxicity affecting detrimental species without damaging mammals or the environment qualified them to be used in biotechnological applications. Both peptides were employed to develop transgenic crops and these plants were active against insects and nematodes, unveiling their immense potentiality for field applications.

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Section: Entomotoxic Effectsmentioning

confidence: 99%

Section: Entomotoxic Effectsmentioning

confidence: 99%

Structure-Function Insights of Jaburetox and Soyuretox: Novel Intrinsically Disordered Polypeptides Derived from Plant Ureases

et al. 2020

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“…Na Tabela 1 estão as classificações de alguns grupos de inseticidas de acordo com sua fisiologia alvo (SPARKS et al, 2020 ROCHA, 2018). Entre os métodos químicos podem ser encontrados a polimerização interfacial, nessa técnica se usa uma emulsão água/óleo para polimerizar os monômeros líquidos ou sólidos de 1-500µm (KAMBLE et al, 2018); e a inclusão molecular em que normalmente líquidos são encapsulados por β-ciclodextrina (OZKAN et al, 2018).…”

Section: Inseticidasunclassified

BIOINSETICIDAS OBTIDOS POR Bacillus thuringiensis MICROENCAPSULADOS: UMA REVISÃO

Clara¹,

da²,

Silva³

et al. 2020

Ciência, Tecnologia E Inovação: Do Campo À Mesa

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“…Neonicotinoids (IRAC sub-group 4A) binding to this target are the most important class of insecticides and their lasting success is reflected in their market share of~24%. 3 By contrast to insecticides, the target physiology of the main acaricidal classes is different. Based on the distribution of acaricide sales data (AgroWin, 2018), the global acaricide market is currently dominated by six acaricide molecular target sites as exemplified by the frontrunner acaricides: mitochondrial complex II electron transport (MET II) (cyflumetofen,~€18.8 T), mitochondrial complex III electron transport (MET III) (bifenazate, €29.5 T), mitochondrial complex I electron transport (MET I) (pyridaben,~€31.6 T), an ATP-synthase (propargite,~€42.9 T), acetyl coenzyme A carboxylase (ACCase) (spirodiclofen,€ 62.1 T) and the glutamate-gated chloride (GluCl) channel (abamectin,~€126.…”

Section: Introductionmentioning

confidence: 99%

“…The majority of the a.i.s act on nerves (blue) and muscle physiology (green) with fewer compounds acting on respiration, growth and development, midgut, on unknown target or they act non‐specific. Based on distribution of insecticide sales by IRAC MoA main groups on 2018 End‐user sales data (total = $19.8 billion USD) (Agranova, 2019) 3 …”

Section: Introductionmentioning

confidence: 99%

Status and outlook for acaricide and insecticide discovery

Jeschke

2020

Pest Management Science

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To guarantee sustainability and progress, the agrochemical industry is faced with several major challenges. Currently, loss of active ingredients due to consumer perception, changing grower needs and ever-changing regulatory requirements is far higher than the number being introduced into the market. Therefore, there is a need to develop new products that can provide improved efficacy, selectivity and favorable environmental profiles. Strategies to achieve these goals are the search for acaricides and insecticides with new modes of action, or the discovery of novel molecules with activity on the most attractive target sites having resistance breaking properties against pest species. In this context, the introduction of halogen atoms or asymmetric centers into an active ingredient remains an important tool to modulate their properties, but so too is the pro-pesticide concept. This review gives an overview of agrochemicals launched over the past 8 years, reflects new insights into known mechanisms of action, and describes the status and outlook for acaricide and insecticide discovery. Supporting information may be found in the online version of this article.

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Insecticides, biologics and nematicides: Updates to IRAC’s mode of action classification - a tool for resistance management

Cited by 301 publications

References 22 publications

Structure-Function Insights of Jaburetox and Soyuretox: Novel Intrinsically Disordered Polypeptides Derived from Plant Ureases

Structure-Function Insights of Jaburetox and Soyuretox: Novel Intrinsically Disordered Polypeptides Derived from Plant Ureases

BIOINSETICIDAS OBTIDOS POR Bacillus thuringiensis MICROENCAPSULADOS: UMA REVISÃO

Status and outlook for acaricide and insecticide discovery

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