Insensitivity of Bonnet Monkeys to (D-Ala6, Des-Gly10) LHRH Ethylamide, a Potent New Luteinizing Hormone Releasing Hormone Analogue in Rats and Mice

The Effects of Gonadectomy and Oestradiol-17j3 on Pituitary Responsiveness to LH-RH in the Adult Male Marmoset (Callithrix jacchus)

“…Bonnet monkeys also appear relatively insensitive to exogenous LH‐RH, since a 100‐μg bolus (27 μg/kg b.w. ), when injected into oophorectomized females, induces an increase in LH levels to only 140% of baseline values (24). In the remaining primates for which data are available, the sensitivity to LH‐RH appears to be intermediate between that in macaque species and man.…”

“…The control of LH secretion in primates, however, is not fully understood, and detailed studies in primates other than the rhesus monkeys and man are lacking. Accordingly, there is a need for further studies in alternative primate species, particularly since several investigations have reported the rhesus monkey and other macaques to be relatively insensitive to the action of exogenous LH‐RH (1, 11, 16, 24, 34). Since there are considerable practical advantages in using the common marmoset monkey (Callithrix jacchus) as a laboratory primate (adaptability, captive breeding performance and ease of maintenance and handling) (14), examination of LH‐RH action in this species may be of value.…”