Insertion-Deletion Polymorphism in the Angiotensin-Converting Enzyme (ACE) Gene Among Sudanese, Somalis, Emiratis, and Omanis

Bayoumi, Riad; Şi̇mşek, Mehmet; Yahya, Taher; Bendict, Sheela; Al-Hinai, Ali T.; Al-Barwani, Hameeda; Hassan, Musaab

doi:10.1353/hub.2006.0022

Cited by 25 publications

(16 citation statements)

References 24 publications

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“…The documented RM risk factor, the ACE D allele, was not associated with RM in the present study. It is interesting to note that the ACE D allele frequency in the population examined in this study is high relative to other reports and similar to some Arab populations [30] . In another study, patients with unexplained RM had an increased prevalence of the ACE D/D genotype compared with controls (32.1 vs. 23.6%, p = 0.11), although this was not statistically significant [31] .…”

Section: Ace I/d Gene Polymorphism and Rmsupporting

confidence: 84%

Polymorphisms in NOS3, ACE and PAI-1 Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip

Sallout

Sharif

2010

Med Princ Pract

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Objective: This study was conducted to investigate the correlation between spontaneous recurrent miscarriage (RM) and common polymorphisms in angiotensin-converting enzyme (ACE), plasminogen activator inhibitor 1 (PAI-1) and endothelium-derived nitric oxide synthase 3 (NOS3) genes among women experiencing RM in the Gaza Strip. Methods: The presence of these genetic profiles was determined for 100 women who had had at least 3 constitutive abortions and 100 controls without any history of abortion using molecular biological techniques. Results: The ACE D/D polymorphism was present in 49% of the study population and in 54% of the controls (p = 0.479). Similarly, there was no significant difference detected in the distribution of polymorphisms for PAI-1, with the 4G/4G genotype present in the study group and in controls (p = 1.00). NOS3 4a/4a was present in 4% of the study group and in none of the 100 controls (p = 0.123). In this study, we also discovered a new variant in the NOS3 gene which was named 4c allele and was encountered in 1 patient and in 1 control subject. Conclusion: There was no significant association between ACE I/D, PAI-1 4G/5G and NOS3 4a/4b and the occurrence of first-trimester RM. In-depth investigation of the association of NOS3 4a/4a with RM is strongly recommended.

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Section: Ace I/d Gene Polymorphism and Rmsupporting

confidence: 84%

Polymorphisms in NOS3, ACE and PAI-1 Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip

Sallout

Sharif

2010

Med Princ Pract

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“…In our study, the frequency of D allele in the Egyptian control population is 0.69, which is approximately the same as found by Salem and Batzer (2009) (Frossard et al, 1997;Comas et al, 2000;Bayoumi et al, 2006). However, the frequency of D allele is moderate among the western population although the predominance of the D allele over the I one was evident in studies done on the French (0.54), Dutch (0.54), American (0.56), Danish (0.55), and English (0.55) populations (Cambien et al, 1992;Schunkert et al, 1994;Lindpaintner et al, 1995;Tarnow et al, 1995;Chowdhury et al, 1996).…”

Section: Discussionsupporting

confidence: 91%

Association of Angiotensin-Converting EnzymeACEGene Polymorphism with ACE Activity and Susceptibility to Vitiligo in Egyptian Population

Badran

Nada

Hassan

2015

Genetic Testing and Molecular Biomarkers

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“…Broader conclusions, such as identifying the origin of a particular polymorphism on the basis of its relative frequency, are less controversial; and this is more so with Alu elements, which are considered to be highly stable polymorphisms, where deletion of newly inserted elements is a rare event (Stoneking et al, 1997). Low frequencies of the insertion are therefore indicative of the ancestral state, and African populations tend to have not only the lowest frequency of the insertion (Bayoumi et al, 2006) but also the greatest variation in frequency (Stoneking et al, 1997). On this basis it would appear that the ALU deletion within the ACE gene was, of the populations studied here, Middle Eastern in origin.…”

Section: (I) Ace I/d Genotype Distributionmentioning

confidence: 99%

The geographic distribution of the ACE II genotype: a novel finding

2007

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SummaryAngiotensin converting enzyme (ACE) gene polymorphism insertion (I) or deletion (D) has been widely studied in different populations, and linked to various functional effects and associated with common diseases. The purpose of the present study was to investigate the relationship between the ACE I/D frequency in different populations and geographic location; ACE I/D allele frequency in the Lebanese population and ACE II genotype contribution to the geographic trend were also identified. Five hundred and seventy healthy volunteers were recruited from the Lebanese population. Genomic DNA was extracted from buccal cells, and amplified by polymerase chain reaction; products were then identified by gel electrophoresis. The frequencies of the different ACE I/D genotypes were determined and tested for Hardy-Weinberg equilibrium (HWE). To assess the relationship between ACE I/D frequency and geographic location, and to identify how the Lebanese population contributes to the geographic trend in ACE I/D frequencies, Eurasian population samples and Asians were incorporated in the analyses from the literature. The frequency of the I allele in the Lebanese population was 27% and the corresponding II genotype was at a frequency of 7 . 37% (in HWE ; P=0 . 979). The ACE I allele and genotype frequencies show an association with longitude, with frequencies increasing eastwards and westwards from the Middle East.

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Insertion-Deletion Polymorphism in the Angiotensin-Converting Enzyme (ACE) Gene Among Sudanese, Somalis, Emiratis, and Omanis

Cited by 25 publications

References 24 publications

Polymorphisms in <i>NOS3, ACE </i>and<i> PAI-1</i> Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip

Polymorphisms in <i>NOS3, ACE </i>and<i> PAI-1</i> Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip

Association of Angiotensin-Converting EnzymeACEGene Polymorphism with ACE Activity and Susceptibility to Vitiligo in Egyptian Population

The geographic distribution of the ACE II genotype: a novel finding

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