Insertion of I-125 seed-loaded stent for inoperable hilar cholangiocarcinoma.

Gao, Fulei; Wang, Yong; Liu, Jian; Zhu, Guangyu; Huang, Xiaochao; Ren, Daoyuan; Guo, Jialong

doi:10.5114/wiitm.2021.105530

Cited by 7 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inclusion criteria were patients who: (1) were diagnosed with HC, (2) deemed inoperable, and (3) exhibited obstructive jaundice. The excluded patients were: (1) patients with an Eastern Cooperative Oncology Group performance status of ≥ 3, (2) individuals who have undergone liver resection in the past, (3) patients who have previously received treatment through biliary stent insertion or drainage, and (4) individuals who have declined stent insertion.…”

Section: Design and Populationmentioning

confidence: 99%

“…H ilar cholangiocarcinoma (HC) is a prevalent malignant neoplasm, often leading to obstructive jaundice. [1][2][3] However, according to an investigation, 4 it has been shown that a significant proportion, ranging from 70% to 80%, of cases involving individuals with HC are deemed inoperable at the time of diagnosis. The implantation of a stent is considered the primary therapeutic choice for cases with inoperable HC accompanied by obstructive jaundice.…”

mentioning

confidence: 99%

“…Hilar cholangiocarcinoma (HC) is a prevalent malignant neoplasm, often leading to obstructive jaundice 1–3 . However, according to an investigation, 4 it has been shown that a significant proportion, ranging from 70% to 80%, of cases involving individuals with HC are deemed inoperable at the time of diagnosis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Stent Insertion for Inoperable Hilar Cholangiocarcinoma: Comparison Between Unilateral Radioactive Stent and Bilateral Normal Stent

Liu,

Cui,

Tong

et al. 2024

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

View full text Add to dashboard Cite

Objective: To comparatively analyze the clinical efficacy and safety of unilateral radioactive stent (RS) insertion versus bilateral normal stent (NS) insertion in patients with inoperable hilar cholangiocarcinoma (HC). Patients and Methods: Patients with inoperable HC were treated in our hospital from January 2016 to December 2020. The treatment approach included the insertion of either unilateral RS or bilateral NS, evaluating the efficacy and safety of therapy in 2 distinct groups. Results: A total of 58 individuals experienced the insertion of a unilateral RS, whereas 57 patients underwent the insertion of bilateral NS. No statistically significant difference between the unilateral RS and bilateral NS groups was seen in the technical success rates (98.3% vs 94.7%, P = 0.598) and clinical success rates (98.2% vs 100%, P = 0.514). While there is no statistically significant difference in the rates of stent restenosis (19.3% vs 9.3%, P = 0.132) between the two groups, the unilateral RS group demonstrated substantially longer stent patency (202 vs 119 d, P = 0.016) and overall survival (229 vs 122 d, P = 0.004) compared with the bilateral NS group. Moreover, 8 patients (14.0%) in the unilateral RS group and 14 patients (25.9%) in the bilateral NS group had postoperative complications with no significant difference (P = 0.116). Conclusion: When inserting stents for inoperable HC, both unilateral RS and bilateral NS insertion procedures have demonstrated favorable therapeutic efficacy. Nevertheless, inserting a unilateral RS provided a longer duration of stent patency and overall survival than implantation of bilateral NS.

show abstract

Section: Design and Populationmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Stent Insertion for Inoperable Hilar Cholangiocarcinoma: Comparison Between Unilateral Radioactive Stent and Bilateral Normal Stent

Liu,

Cui,

Tong

et al. 2024

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

View full text Add to dashboard Cite

show abstract

“…Critically, these 125 I seeds can simultaneously deliver a high radiation level to the tumor while mainly avoiding the irradiation of surrounding healthy tissue [4]. A few reports have assessed the relative clinical efficacy of traditional and radioactive stent insertion procedures in patients with HC [9][10][11], but prospective studies on this topic are lacking.…”

Section: Introductionmentioning

confidence: 99%

Radioactive stent insertion for inoperable hilar cholangiocarcinoma: a prospective randomized controlled trial.

Song¹,

Feng²,

Fu³

et al. 2022

Videosurgery and Other Miniinvasive Techniques

View full text Add to dashboard Cite

Introduction: Hilar cholangiocarcinoma (HC) is the leading cause of hilar biliary obstruction. Radioactive stent insertion has been utilized extensively for inoperable HC patients.Aim: To assess the relative clinical outcomes of inoperable HC patients who underwent either normal or radioactive stent insertion. Material and methods: This single-center, prospective, randomized, open-label study enrolled 90 inoperable HC patients from April 2021 to March 2022 and randomly assigned them to normal or radioactive stent groups (n = 45/ group), with clinical data then being compared between these groups. Results: Technical success rates in the normal and radioactive stent insertion groups were 93.3% and 97.9%, respectively (p = 1.000), and clinical success rates were similarly consistent in both groups (95.3% vs. 97.7%, p = 0.983). Individuals in the radioactive stent group exhibited significantly longer median stent patency as compared to the normal stent group (195 days vs. 115 days, p < 0.001), and median overall survival (OS) was also significantly increased in the normal stent group (242 days vs. 125 days, p = 0.002). In the normal stent insertion group, 6 (14.3%) and 5 (11.9%) patients experienced early and late postoperative complications, respectively. Additionally, early and late postoperative complications impacted 7 (16.3%) and 8 (18.6%) patients in the radioactive stent insertion group, respectively. Complication rates were comparable in these 2 patient groups. Conclusions: Radioactive stent insertion represents a safe and effective strategy for patients with inoperable HC, potentially contributing to prolonged stent patency and OS relative to normal stent insertion.

show abstract

“…Hilar cholangiocarcinoma (HC) is a prevalent malignant tumor involving the hepato-biliary system [1][2][3]. Unfortunately, HC is asymptomatic in the early stages.…”

Section: Introductionmentioning

confidence: 99%

Bilateral versus unilateral radioactive stent insertion for hilar cholangiocarcinoma.

Zhang¹,

Wang²,

Xu³

et al. 2022

Videosurgery and Other Miniinvasive Techniques

View full text Add to dashboard Cite

Introduction: Radioactive stent insertion (RSI) is widely used for patients with obstructive hilar cholangiocarcinoma (HC) to increase the stent patency and overall survival (OS). However, one controversy of treating HC patients is determining whether to use unilateral or bilateral stenting. General knowledge on unilateral and bilateral RSI efficacy is still lacking. Aim: To evaluate the clinical efficacy and long-term prognoses of unilateral and bilateral RSI in HC patients. Material and methods: Between January 2016 and December 2020, all HC patients who received unilateral and bilateral RSI at our hospital were selected for this study. We compared the treatment efficacy and long-term prognosis of patients undergoing these two procedures. Results: Overall, 65 HC patients received either unilateral (n = 33) or bilateral (n = 32) RSI. There were no significant differences in the technical (both 100%) and functional (97.0% vs. 90.6%, p = 0.584) success rates between the 2 groups. Stent re-obstruction occurred in 6 and 9 patients in the unilateral and bilateral groups, respectively (p = 0.341). Median stent patency was 214 and 233 days in the unilateral and bilateral groups, respectively (p = 0.650). Median OS was 240 and 281 days in the unilateral and bilateral groups, respectively (p = 0.068). Lastly, the total complication rate was significantly lower in the unilateral group, as compared to the bilateral group (12.1% vs. 34.4%, p = 0.033). Conclusions: Unilateral and bilateral RSI provided comparable clinical efficacy and long-term prognoses of HC patients. However, unilateral stenting exhibited a markedly lower complication rate.

show abstract

Insertion of I-125 seed-loaded stent for inoperable hilar cholangiocarcinoma.

Cited by 7 publications

References 15 publications

Stent Insertion for Inoperable Hilar Cholangiocarcinoma: Comparison Between Unilateral Radioactive Stent and Bilateral Normal Stent

Stent Insertion for Inoperable Hilar Cholangiocarcinoma: Comparison Between Unilateral Radioactive Stent and Bilateral Normal Stent

Radioactive stent insertion for inoperable hilar cholangiocarcinoma: a prospective randomized controlled trial.

Bilateral versus unilateral radioactive stent insertion for hilar cholangiocarcinoma.

Contact Info

Product

Resources

About