Insertion-responsive microneedles for rapid intradermal delivery of canine influenza vaccine

Choi, In-Jeong; Kang, Aram; Ahn, Myun-Hwan; Jun, Hyesun; Baek, Seungin; Park, Jung Hwan; Na, Woonsung; Choi, Seong-O

doi:10.1016/j.jconrel.2018.08.017

Cited by 83 publications

(45 citation statements)

References 49 publications

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“…A study investigated the effect of different excipients and stabilizers and found that instead of carboxymethylcellulose, hydroxyethylcellulose and methylcellulose without surfactant but with trehalose were better able to stabilize hemagglutinin titers in viruses (Kim et al, 2016a). Use of disaccharides such as trehalose, sucrose, and maltose as excipients has helped to stabilize a broad range of materials, such as DNA (Pearton et al, 2012), live measles virus (Edens et al, 2013), erythropoietin (Peters et al, 2012), live adenovirus and modified vaccinia virus Ankara (Vrdoljak et al, 2012), inactivated influenza virus (Quan et al, 2009;Kim et al, 2010a;Kommareddy et al, 2013), inactivated rotavirus (Moon et al, 2013), human growth hormone (Ameri et al, 2014), live bacillus Calmette-Guérin vaccine (Hiraishi et al, 2011), influenza virus-like particles (Kim et al, 2010b), ebola virus glycoprotein (Liu et al, 2018), and inactivated canine influenza virus (Choi et al, 2018). A list of stabilizers with their respective ranges that have been added to coating liquids are presented in Table 3.…”

Section: Coating Solution Excipientsmentioning

confidence: 99%

“…Since microneedles are often dipped in aqueous solutions for coating, they should not be constructed from water-soluble materials. A few studies have, however, reported microneedles made from hyaluronic acid (Liu et al, 2016;Choi et al, 2018). In these studies, to coat microneedles made from hyaluronic acid, the microneedles were dipped rapidly into the aqueous coating solutions to minimize microneedle dissolution (Liu et al, 2016;Choi et al, 2018).…”

Section: Materials Of Microneedle Fabricationmentioning

confidence: 99%

“…A few studies have, however, reported microneedles made from hyaluronic acid (Liu et al, 2016;Choi et al, 2018). In these studies, to coat microneedles made from hyaluronic acid, the microneedles were dipped rapidly into the aqueous coating solutions to minimize microneedle dissolution (Liu et al, 2016;Choi et al, 2018). In one study however, the microneedles were first frozen to reduce their solubility in water (Choi et al, 2018).…”

Section: Materials Of Microneedle Fabricationmentioning

confidence: 99%

“…These include small molecules, peptides, proteins, short nucleic acids, DNA, viruses, virus-like particles, polymeric particles, and insoluble inorganic particles (Cormier et al, 2004;Gill and Prausnitz, 2007a;Kim et al, 2010b;Zhang et al, 2012b). More specifically, coated microneedles have been widely investigated to study influenza vaccination (Kim et al, 2011;McNeilly et al, 2014;Wang et al, 2014;Fernando et al, 2016;Choi et al, 2018). Additionally, coated microneedles have also been used to deliver antigens for other infectious diseases such as diphtheria (Schipper et al, 2017;Du et al, 2018), ebola (Liu et al, 2018), hepatitis (Andrianov et al, 2009;Gill et al, 2010), herpes simplex virus (Chen et al, 2010;Kask et al, 2010), human immunodeficiency virus Caucheteux et al, 2016), human papillomavirus (Kines et al, 2015), Leishmania (Moreno et al, 2017), measles (Edens et al, 2013), pneumonia (Pearson et al, 2015), polio (Muller et al, 2016), severe fever with thrombocytopenia syndrome (Jung et al, 2017), smallpox (Hooper et al, 2007), tuberculosis (Hiraishi et al, 2011), West Nile virus (Prow et al, 2010), and chikungunya (Prow et al, 2010).…”

Section: Biomedical Applications Animal Models and Human Studies Pumentioning

confidence: 99%

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Microneedle Coating Methods: A Review with a Perspective

Ingrole¹,

Gill²

2019

J Pharmacol Exp Ther

142

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A coated microneedle array comprises sharp micrometer-sized needle shafts attached to a base substrate and coated with a drug on their surfaces. Coated microneedles are under investigation for drug delivery into the skin and other tissues, and a broad assortment of active materials, including small molecules, peptides, proteins, deoxyribonucleic acids, and viruses, have been coated onto microneedles. To coat the microneedles, different methods have been developed. Some coating methods achieve selective coating of just the microneedle shafts, whereas other methods coat not only microneedle shafts but also the array base substrate. Selective coating of just the microneedle shafts is more desirable since it provides control over drug dosage, prevents drug waste, and offers high delivery efficiency. Different excipients are added to the coating liquid to modulate its viscosity and surface tension in order to achieve uniform coatings on microneedles. Coated microneedles have been used in a broad range of biomedical applications. To highlight these different applications, a table summarizing the different active materials and the amounts coated on microneedles is provided. We also discuss factors that should be considered when deciding suitability of coated microneedles for new-drug delivery applications. In recent years, many coated microneedles have been investigated in human clinical trials, and there is now a strong effort to bring the first coated microneedle-based product to market.

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Section: Coating Solution Excipientsmentioning

confidence: 99%

Section: Materials Of Microneedle Fabricationmentioning

confidence: 99%

Section: Materials Of Microneedle Fabricationmentioning

confidence: 99%

Section: Biomedical Applications Animal Models and Human Studies Pumentioning

confidence: 99%

See 2 more Smart Citations

Microneedle Coating Methods: A Review with a Perspective

Ingrole¹,

Gill²

2019

J Pharmacol Exp Ther

142

View full text Add to dashboard Cite

show abstract

“…In recent years, the fit‐for‐purpose performance of both solid non‐degradable and removable microneedle arrays and dissolving/degradable microneedle for vaccine delivery has been demonstrated extensively in both in vitro and in vivo studies. For example, vaccine‐delivering microneedles have been tested in the context of infectious diseases, including human papilloma virus (HPV), DNA‐delivered attenuated west Nile virus, inactivated rotavirus, hepatitis B/C, Bacillus Calmette‐Guérin, influenza, measles, poliovirus,52b,68 and Ebola . Recently, a microneedle patch was designed to co‐deliver vaccine and a cytokine adjuvant (granulocyte‐macrophage colony stimulating factor (GM‐CSF)) for improved vaccination 66b.…”

Section: Microneedle Patches For Transdermal Deliverymentioning

confidence: 99%

Micro‐ and Nanosystems for Advanced Transdermal Delivery

Alba

Tabassum

et al. 2019

Advanced Therapeutics

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The skin is the largest and most accessible organ in the human body and, as such, it appears as the most convenient portal for drug delivery. However, the skin is also a formidable barrier which, while protecting us from physical, chemical, and immunological agents, requires appropriate technology for effective delivery. Today, the most effective administration method for large, lipophobic, and polar molecules continues to be hypodermic injection, which is associated with pain, needle phobia, and stick injury. As an alternative, a range of advanced strategies to overcome the skin barrier have been established over the last few decades including chemical enhancement, sonophoresis, iontophoresis, electroporation, thermal ablation, and mechanical approaches. Encouraged by the advances in nanotechnology, micro-and nanosystems have emerged as powerful tools to overcome the skin barrier, enabling significant advances on the existing methods. In particular, microneedle-and nanoparticle-assisted transdermal delivery has gained significant traction and will most likely have a strong impact in the field. In this review, the most recent progress in the field of transdermal delivery based on microneedle and nanoparticle delivery systems is discussed and examples of key therapeutic application are provided. Finally, a critical summary is presented alongside a vision for future research directions.

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Concept Design of Transdermal Microneedles for Diagnosis and Drug Delivery: A Review

2021

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Microneedles (MNs) are one of intriguing approach for efficient transdermal drug delivery that penetrates the protective skin barrier in a painless and less invasive way. In recent years, multidisciplinary studies have been conducted to improve their properties to meet stringent requirements and obtain market release approval. This review aims to summarize the latest concept design with unique properties in the advancement of transdermal MNs for diagnosis and therapeutic application. Numerous significant innovation strategies in improving MNs in aspects of adhesion ability, dosing capacity, drug‐controlled release, diffusion control ability, site‐targeted and on‐demand drug delivery, and biomarker or drug release monitoring are presented. Given that the majority of technologies used in such design are exclusively laboratory‐based, striving toward commercialization is a critical aspect of the revolution. Key challenges and future perspectives in industrial and economic aspects are identified with the intention of translating the reviewed technologies into marketable products.

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Insertion-responsive microneedles for rapid intradermal delivery of canine influenza vaccine

Cited by 83 publications

References 49 publications

Microneedle Coating Methods: A Review with a Perspective

Microneedle Coating Methods: A Review with a Perspective

Micro‐ and Nanosystems for Advanced Transdermal Delivery

Concept Design of Transdermal Microneedles for Diagnosis and Drug Delivery: A Review

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