Inside Cover: Exploring the Potential of Norbornene‐Modified Mannosamine Derivatives for Metabolic Glycoengineering (ChemBioChem 14/2016)

Abstract

The inside cover picture shows how metabolic glycoengineering can be explained in a creative way (idea: Sven Epple). Modified monosaccharides are used to engineer the cell surfaces’ glycans with functional groups. Surprisingly, bulky norbornenes can also be used as modifiers. In a second step, these modifications are “colored” through a bioorthogonal ligation reaction with a tetrazine or cyclooctyne that is linked to a label. More information can be found in the full paper by V. Wittmann et al. on page 1374 in Issue 14, 2016 (DOI: 10.1002/cbic.201600197).