Inside the Phenomenological Aspects of Wet Granulation: Role of Process Parameters

Abstract

Granulation is a size-enlargement process by which small particles are bonded, by means of various techniques, in coherent and stable masses (granules), in which the original particles are still identifiable. In wet granulation processes, the powder particles are aggregated through the use of a liquid phase called binder. The main purposes of sizeenlargement process of a powder or mixture of powders are to improve technological properties and/or to realize suitable forms of commercial products. A modern and rational approach in the production of granular structures with tailored features (in terms of size and size distribution, flowability, mechanical and release properties, etc.) requires a deep understanding of phenomena involved during granules formation. By this knowledge, suitable predictive tools can be developed with the aim to choose right process conditions to be used in developing new formulations by avoiding or reducing costs for new tests. In this chapter, after introductive notes on granulation process, the phenomenological aspects involved in the formation of the granules with respect to the main process parameters are presented by experimental demonstration. Possible mathematical approaches in the granulation process description are also presented and the one involving the population mass balances equations is detailed.

Analysis of the Influence of Process and Formulation Properties on the Drying Behavior of Pharmaceutical Granules in a Semi-Continuous Fluid Bed Drying System

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Distribusi Ukuran Granul dari Tepung Singkong dengan Tepung Tapioka sebagai Pengikat pada Rotary Drum Granulator

“…Untuk mendapatkan butiran dari serbuk halus, sebagian besar sistem granulasi menggunakan bahan pengikat (Takano et al, 2002). Granulasi dimaksudkan untuk memperbaiki sifat aliran dan kompresibilitas, memadatkan bahan-bahan, membuat campuran seragam yang tidak memisah, mengendalikan pelepasan zat aktif, mengurangi debu dan memperbaiki penampakan tablet (Simone et al, 2018). Sifat aliran atau daya alir serbuk dipengaruhi oleh banyak faktor, diantaranya adalah ukuran partikel, bentuk, kerapatan, kelengketan, muatan elektrostatik, dan kondisi permukaan partikel lainnya.…”

A Comprehensive Review on Effervescent Tablets

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