Abstract. The South Pacific Subtropical High (SPSH) is a predominant feature of South American climate. The variability of this high-pressure center induces changes in the intensity of coastal alongshore winds and precipitation, among others, over southwestern South America. In recent decades, a strengthening and expansion of the SPSH have been observed and attributed to the current global warming. These changes have led an intensification of the southerly winds along the coast of northern to central Chile, and a decrease in precipitation from central to southern Chile. Motivated by improving our understanding about the regional impacts of climate change in this part of the Southern Hemisphere, we analyze SPSH changes during the two most extreme climate events of the last millennium: the Little Ice Age (LIA) and the Current Warm Period (CWP: 1970–2000), based on paleoclimate records and CMIP5/PMIP3 model simulations. In order to assess the level of agreement of general circulation models, we also compare them with ERA-Interim reanalysis data for the 1979–2009 period as a complementary analysis. Finally, with the aim of evaluating future SPSH behaviour, we include 21th century projections under a RCP8.5 scenario in our analyses. Our results indicate that during the relative warm (cold) period, the SPSH expands (contracts). Together with this change, alongshore winds intensify (weaken) south (north) of ~ 35º S; also, Southern Westerly Winds become stronger (weaker) and shift southward (northward). Model results generally underestimate reanalysis data. These changes are in good agreement with paleoclimate records, which suggest that these variations could be related to tropical climate dynamics but also to extratropical phenomena. However, although models adequately represent most of the South American climate changes, they fail in representing the Intertropical Convergence Zone - Hadley Cell system dynamics. Climate model projections indicate that changes recently observed will continue during next decades, highlighting the need to establish effective mitigation and adaptation strategies against their environmental and socio-economic impacts.