Insight into COVID-19's epidemiology, pathology, and treatment

Aimrane, Abdelmohcine; Laaradia, Mehdi Ait; Sereno, Denis; Perrin, Pascale; Draoui, Ahmed; Bougadir, Blaid; Mohamed, Haji; Zahir, Mustapha; Fdil, Naı̈ma; Hiba, Omar El; Hidan, Moulay Abdelmonaim El; Kahime, Kholoud

doi:10.1016/j.heliyon.2022.e08799

Cited by 32 publications

(19 citation statements)

References 194 publications

(245 reference statements)

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“…SARS-CoV-2, the etiological agent of COVID-19, belongs to the Betacoronavirus genus, the same as MERS-CoV and SARS-CoV according to clustering based on genetic similarities [ 8 ]. These three viruses emerged in the present century, switching from animal hosts to the human species, with the last of them, SARS-CoV-2, spreading at pandemic level [ 9 ].…”

Section: A General Perspective For Sars-cov-2mentioning

confidence: 99%

Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Ortega

García-Montero

Fraile-Martínez

et al. 2022

JPM

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Over the two years that we have been experiencing the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic, our challenges have been the race to develop vaccines and the difficulties in fighting against new variants due to the rapid ability of the virus to evolve. In this sense, different organizations have identified and classified the different variants that have been emerging, distinguishing between variants of concern (VOC), variants of interest (VOI), or variants under monitoring (VUM). The following review aims to describe the latest updates focusing on VOC and already de-escalated variants, as well as to describe the impact these have had on the global situation. Understanding the intrinsic properties of SARS-CoV-2 and its interaction with the immune system and vaccination is essential to make out the underlying mechanisms that have led to the appearance of these variants, helping to determine the next steps for better public management of this pandemic.

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Section: A General Perspective For Sars-cov-2mentioning

confidence: 99%

Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Ortega

García-Montero

Fraile-Martínez

et al. 2022

JPM

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“…Coronavirus disease 2019 (COVID-19) is an extremely contagious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; Borges do Nascimento et al., 2021 ; Aimrane et al., 2022 ; Al-Awwal et al., 2022 ). Recent evidence indicates over 430 million cases and 5.92 million deaths worldwide ( Al-Awwal et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recent evidence indicates over 430 million cases and 5.92 million deaths worldwide ( Al-Awwal et al., 2022 ). The early disease recognition of COVID-19 is crucial not only for the prompt diagnosis and treatment of patients, but also for effective public health surveillance, containment, and response ( Borges do Nascimento et al., 2021 ; Aimrane et al., 2022 ; Al-Awwal et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Development of a high-sensitivity and short-duration fluorescence in situ hybridization method for viral mRNA detection in HEK 293T cells

Wang²,

Uddin³

et al. 2022

Front. Cell. Infect. Microbiol.

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Coronavirus disease 2019 (COVID-19) is an extremely contagious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early disease recognition of COVID-19 is crucial not only for prompt diagnosis and treatment of the patients, but also for effective public health surveillance and response. The reverse transcription-polymerase chain reaction (RT-PCR) is the most common method for the detection of SARS-CoV-2 viral mRNA and is regarded as the gold standard test for COVID-19. However, this test and those for antibodies (IgM and IgG) and antigens have certain limitations (e.g., by yielding false-negative and false-positive results). We have developed an RNA fluorescence in situ hybridization (FISH) method for high-sensitivity detection of SARS-CoV-2 mRNAs in HEK 293T cell cultures as a model. After transfection of HEK 293T cells with plasmids, Spike (S)/envelope (E) proteins and their mRNAs were clearly detected inside the cells. In addition, hybridization time could be reduced to 2 hours for faster detection when probe concentration was increased. Our approach might thus significantly improve the sensitivity and specificity of SARS-CoV-2 detection and be widely applied for the high-sensitivity single-molecular detection of other RNA viruses (e.g., Middle East respiratory syndrome coronavirus (MERS-CoV), Hepatitis A virus, all influenza viruses, and human immunodeficiency virus (HIV)) in various types of samples including tissue, body fluid, blood, and water. RNA FISH can also be utilized for the detection of DNA viruses (e.g., Monkeypox virus, human papillomavirus (HPV), and cytomegalovirus (CMV)) by detection of their mRNAs inside cells or body fluid.

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“…SARS-CoV-2 infections have spread worldwide, with a rapid increase in cases and deaths, becoming a pandemic 1 . It is a disease with respiratory manifestations, a clinical situation that varies from asymptomatic infections to severe cases, and may progress to death.…”

Section: Introductionmentioning

confidence: 99%

Maternity in times of the Covid-19 pandemic: what mothers admitted in a reference hospital have to tell us

Joaquim

Dittz²,

Leão³

et al. 2022

Interface (Botucatu)

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The Covid-19 pandemic has affected all aspects of our lives. Women in the perinatal period have unique needs, demanding health and safety guidelines regarding the risks associated to social isolation. The objective was to know the women’s experience during pregnancy or puerperium in the pandemic while being cared at a hospital. Qualitative study referenced on concepts of integrality of care and daily life. Eighteen pregnant and postpartum participated. Three themes emerged: Repercussions on pregnancy and puerperium, repercussions on practical life, and coping strategies created by women. The reports reveal different repercussions of the pandemic in the lives of women and their families, also the strategies and precautions used to mitigate its adverse effects. We suggest directing preventive measures and public health policies to prioritize pregnant and postpartum women, recognizing and embracing subjective issues involved at this moment in women’s lives.

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Insight into COVID-19's epidemiology, pathology, and treatment

Cited by 32 publications

References 194 publications

Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Development of a high-sensitivity and short-duration fluorescence in situ hybridization method for viral mRNA detection in HEK 293T cells

Maternity in times of the Covid-19 pandemic: what mothers admitted in a reference hospital have to tell us

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