The aim of this study was to examine the gender differences in postural balance, physical activity (PA), and body mass index (BMI) and body composition in visually impaired (VI) athletes. A total of 66 athletes took part in this study. After anthropometric measurements, the PA level was assessed by the International Physical Activity Questionnaire-Short Form. The modified Clinical Test of Sensory Integration and Balance tool was used to assess postural balance in four standing conditions: (1) eyes-open on a firm surface, (2) eyes-closed on a firm surface, (3) eyes-open on a compliant surface, and (4) eyes closed on a compliant surface. Findings revealed gender differences in anthropometric measurements ( p < .05). No statistically significant differences were found in fat mass and fat free mass between sighted male and VI male athletes and between sighted female and VI female athletes ( p > .05). Weekly, high and moderate PA levels as well as walking were found to be different across the four groups ( p < .05). Assessment of postural balance in four standing conditions revealed no gender differences in sighted athletes ( p > .05). Postural balance scores in conditions 1 and 3 showed significant gender differences ( p < .05), whereas conditions 2 and 4 showed no gender differences in athletes with VI ( p > .05). Gender-matched differences were also apparent in conditions 1 and 3, revealing that VI male and female athletes scored worse in these conditions than their sighted male and female counterparts ( p < .05). There is a delay in balance parameter in VI athletes even if their fitness levels are similar with their sighted counterparts. The present findings could also be useful for gender-specific training session preparations in VI sports.