2014
DOI: 10.1016/j.gene.2014.03.045
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Insight into genetic determinants of resting heart rate

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Cited by 9 publications
(7 citation statements)
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References 33 publications
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“…Here in the current study, miR-185-3p was con rmed to display a high level in hyperlipidemia rats. Consistently, the robustly expressed MAML1 has also been validated in the myocardium with ischemia-reperfusion injury [11] and in the heart, spleen, pancreas and leukocytes in peripheral blood [10].…”
Section: Discussionmentioning
confidence: 56%
See 1 more Smart Citation
“…Here in the current study, miR-185-3p was con rmed to display a high level in hyperlipidemia rats. Consistently, the robustly expressed MAML1 has also been validated in the myocardium with ischemia-reperfusion injury [11] and in the heart, spleen, pancreas and leukocytes in peripheral blood [10].…”
Section: Discussionmentioning
confidence: 56%
“…As the major transcriptional co-activator of Notch signaling pathway, MAML1 exerts a pleiotropic role in physiological and pathological signaling networks [9]. MAML1 has been unveiled to be associated with resting heart rate, acting as a putative risk factor for cardiovascular diseases [10]. Moreover, it has been found that mouse myocardial ischemia-reperfusion injury displays high levels of MAML1 [11].…”
Section: Introductionmentioning
confidence: 99%
“…Although similar types of studies have been performed previously in population samples [1013], our study is the first that we know of to attempt to identify genomic regions that influence HR in stable patients with HFrEF. Analysis of this diverse patient cohort revealed a modest but statistically significant difference in HR between self-identifying white and AAs (with AA showing a slightly higher HR) as well as three genomic loci at or near genome-wide significance in at least one analysis for association to HR, of particular interest is a novel locus on Chr.…”
Section: Discussionmentioning
confidence: 78%
“…An increasing number of genome-wide association studies (GWAS) report identified genetic polymorphisms that are associated with certain hemodynamic parameters such as blood pressure [66], resting heart rate [67,68], heart rate variability [69], and cardiac function [70]. These findings provide new insights into underlying biological mechanisms of inter-individual variability of the hemodynamic parameters and their interaction with potentially important diagnostic and therapeutic implications.…”
Section: Genetic Variability and Phenotypic Associationsmentioning
confidence: 99%