Insight into illness in schizophrenia

Goodman, Craig; Knoll, Gabriella; Isakov, Victoria; Silver, Henry

doi:10.1016/j.comppsych.2004.11.002

Cited by 39 publications

(30 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with a number of earlier studies that also failed to a significant association between lack of insight and neurocognitive dysfunction (Cuesta et al, 1995;Collins et al, 1997;Freudenreich et al, 2004;Goodman et al, 2005). Taken together these studies suggest that insight and neurocognitive performance are uncorrelated domains (Carroll et al, 1999), and stand in contrast to the far more consistent observation that clinical symptomotology is significantly associated with poor insight.…”

Section: Insight and Neurocognitive Functionssupporting

confidence: 91%

“…Imaging studies have found dysfunction in cortical areas, which are believed to support these neurocognitive functions, and are also potentially linked with deficits in insight (Raij et al, 2012). However, other studies have failed to detect a relationship between insight and neurocognitive functioning (Cuesta et al, 1995;Collins et al, 1997;Freudenreich et al, 2004;Goodman et al, 2005), thus undermining the view that the lack of insight in schizophrenia reflects neuropsychological impairment.…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning

Zhou

Rosenheck

Mohamed

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

Section: Insight and Neurocognitive Functionssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 92%

Insight in inpatients with schizophrenia: Relationship to symptoms and neuropsychological functioning

Zhou

Rosenheck

Mohamed

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

“…Neuropsychological studies largely support a relationship between poor insight and brain impairment in the frontal (Lysaker et al, 1998; Ritsner & Blumenkrantz, 2007; Young et al, 1993), and prefrontal and parietal lobes (Laroi et al, 2000; McEvoy et al, 1996), although the findings are inconsistent (Arduini et al, 2003; Cuesta & Peralta, 1994; Drake & Lewis, 2003; Freudenreich et al, 2004; Goodman et al, 2005; Kemp & David, 1996). In fact, reviews of neuropsychological studies suggest that the pathogenesis of insight deficits in schizophrenia is associated with impaired functioning in the frontal and parietal lobes, and these insight deficits are similar to impaired insight found in individuals suffering from anosognosia (Pia & Tamietto, 2006; Shad et al, 2006b).…”

mentioning

confidence: 99%

White matter integrity and lack of insight in schizophrenia and schizoaffective disorder

Antonius

Prudent

Rebani

et al. 2011

Schizophrenia Research

View full text Add to dashboard Cite

Objective Poor insight into illness is commonly associated with schizophrenia and has implications for the clinical outcome of the disease. A better understanding of the neurobiology of these insight deficits may help the development of new treatments targeting insight. Despite the importance of this issue, the neural correlates of insight deficits in schizophrenia remain poorly understood. Method Thirty-six individuals diagnosed with schizophrenia or schizoaffective disorder underwent diffusion tensor imaging (DTI). The subjects were assessed on two dimensions of insight (symptom awareness and attribution of symptoms) using the Scale to Assess Unawareness of Mental Disorder (SUMD). Level of psychosis was assessed with the Positive and Negative Syndrome Scale (PANSS). Results White matter abnormalities in the right superior frontal gyrus, left middle frontal gyrus, bilateral parahippocampal gyrus, adjacent to the right caudate head, right thalamus, left insula, left lentiform nucleus, left fusiform gyrus, bilateral posterior cingulate, left anterior cingulate, right cingulate gyrus, left lingual gyrus, and bilateral claustrum were associated with symptom unawareness. Misattribution of symptoms was related to deficits in the white matter adjacent to the right lentiform nucleus, left middle temporal gyrus, and the right precuneus. Conclusions Impaired insight in schizophrenia implicates a complex neural circuitry: white matter deficits in fronto-temporo brain regions are linked to symptom unawareness; compromised temporal and parietal white matter regions are involved in the misattribution of symptoms. These findings suggest the multidimensional construct of insight has multiple neural determinants.

show abstract

“…Various studies speculate that poor insight is related to cognitive deficits ( Another study found relationship between insight and cognition and emotional function, in that convincing evidence related to visual object learning, identification of facial emotions, and verbal working memory and finally authors concluded that poor insight related to cognitive impairment but not particular to executive function in chronic schizophrenia (Goodman, Knoll, Isakov, & Silver, 2005).…”

Section: Insight and Cognitionmentioning

confidence: 99%