2020
DOI: 10.1016/j.envres.2020.109415
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Insight into innate immune response in “Yusho”: The impact of natural killer cell and regulatory T cell on inflammatory prone diathesis of Yusho patients

Abstract: Background: In 1968 in western Japan, polychlorinated biphenyl-contaminated "Kanemi rice oil" was used in cooking, causing food poisoning in many people. More than 50 years have passed since the Yusho incident, and although inflammatory disorders such as suppuration have been observed in Yusho patients, the etiology of this inflammation susceptibility remains obscure. Objectives: To investigate the mechanisms of susceptibility to inflammation in Yusho patients, peripheral immune cell fractions and concentratio… Show more

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Cited by 5 publications
(2 citation statements)
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“…e Ministry of Health and Welfare of Japan did not issue a formal pronouncement until 1968 on the indications of cadmium exposure to "Itai-Itai's" disorder. Mass biphenyl poisoning (PCBs) happened in northern Kyushu, Japan, in 1968, when heat-degrading PCBs tainted rice oil during manufacturing [11]. ese people were seldom known for chloracne skin conditions.…”
Section: Literature Reviewmentioning
confidence: 99%
“…e Ministry of Health and Welfare of Japan did not issue a formal pronouncement until 1968 on the indications of cadmium exposure to "Itai-Itai's" disorder. Mass biphenyl poisoning (PCBs) happened in northern Kyushu, Japan, in 1968, when heat-degrading PCBs tainted rice oil during manufacturing [11]. ese people were seldom known for chloracne skin conditions.…”
Section: Literature Reviewmentioning
confidence: 99%
“…In 1968, the use of “Kanemi rice oil” that was contaminated with PCBs and used for cooking in Japan caused food poisoning in many people. More than 50 years after this incident, these patients still develop inflammatory diseases such as suppuration ( 3 ). Moreover, PCB pollution in natural environments has been confirmed in Japan and worldwide; thus, there are concerns that such pollution could pose a serious threat to human health ( 4 , 5 ).…”
Section: Introductionmentioning
confidence: 99%