Insight into novel β-cyclodextrin-grafted-poly (N-vinylcaprolactam) nanogel structures as advanced carriers for 5-fluorouracil: Equilibrium behavior and pharmacokinetic modeling

El-Zeiny, Hayam M.; Abukhadra, Mostafa R.; Sayed, Osama; Osman, Ali; Ahmed, Sayed A.

doi:10.1016/j.colsurfa.2019.124197

Cited by 91 publications

(146 citation statements)

References 48 publications

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“…About 71% of worldwide deaths are ascribed to non-contagious diseases that are related to physiological, genetic, and environmental factors. 1 From the previous reasons, cancer can be listed as the second main cause of worldwide deaths. 2 Based on the recent expectations, the world will face grave challenges of an interminable increase of cancer deaths by 75%, especially from colorectal cancer (CRC).…”

Section: Introductionmentioning

confidence: 99%

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Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

et al. 2022

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Herein, natural zeolite (clinoptilolite) was functionalized by Na + ions (G.Na + /Clino) utilizing a green tea extract prepared by a green production method as a potential carrier for the 5-fluorouracil (5-Fu) drug with enhanced physicochemical behaviors. The G.Na + /Clino-modified product showed enhanced surface area (312 m 2 /g) and ion-exchange capacity (387 mequiv/100 g). The loading studies reflect high and controlled loading properties of G.Na + /Clino with an actual loading capacity of 291 and 462 mg/g, respectively. The loading reactions of 5-Fu into G.Na + /Clino were of pseudo-second-order kinetics and exhibited Langmuir isotherm properties. This suggested a monolayer and homogeneous loading process by chemical complexation and ion-exchange mechanisms with a Gaussian energy value of 10.47 kJ/mol. Additionally, these reactions were of endothermic and spontaneous nature based on the determined thermodynamic parameters. The release studies demonstrated the 5-Fu release profile for about 150 h at pH 1.2 and for 80 h at pH 7.4. The release reactions had non-Fickian transport properties and were controlled by both erosion and diffusion mechanisms, considering the release kinetic findings and the values of the diffusion exponent (0.42 at pH 1.2 and 0.37 at pH 7.4). The composite showed remarkable biocompatibility based on the measured cell viability and a cytotoxic effect on normal colorectal cells (CCD-18Co). Additionally, the application of G.Na + /Clino as an inorganic carrier for the 5-Fu drug prompted the cytotoxic effect of the drug on colon cancer cell treatment (HCT-116).

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Section: Introductionmentioning

confidence: 99%

“… 8 , 9 Therefore, introducing appropriate carriers or delivery systems for the 5-Fu drug molecule has insistent demand to overcome the common technical and health side effects. 1 , 10 …”

Section: Introductionmentioning

confidence: 99%

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

et al. 2022

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“…More precisely, coagulation, reverse osmosis, membrane separation, electrochemical, dilution, filtration, flotation, softening, and reverse osmosis techniques were used for this suggestion [ 15 , 16 , 17 ]. In comparison to the other methods, adsorption is the most convenient since it is inexpensive, simple, requires less maintenance, is easy to handle, and creates smaller amounts of sediment [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Among the used adsorbents, zeolite is a natural adsorbent with porous architectures.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Application of Zeolite/Acanthophora Spicifera Nanoporous Composite for Adsorption of Congo Red Dye from Wastewater

et al. 2021

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Systematic investigations involving laboratory, analytical, and field trials were carried out to obtain the most efficient adsorbent for the removal of congo red (CR) dye from industrial effluent. Modification of the zeolite (Z) by the Acanthophora Spicifera algae (AS; marine algae) was evaluated in terms of adsorption capability of the zeolite to remove CR dye from aqueous solution. The zeolite/algae composite (ZAS) was fabricated using the wet impregnation technique. The AS, Z, and the synthesized ZAS composite were analyzed utilizing various characterization techniques. The newly synthesized ZAS composite has an adsorption capacity that is significantly higher than that of Z and AS, particularly at low CR concentrations. Batch experiments were carried out to explore the effects of different experimental factors, as well as the dye adsorption isotherms and kinetics. Owing to the presence of intermolecular interactions, the computational analysis showed that the adsorption of the CR molecule on zeolite surfaces is exothermic, energetically favorable, and spontaneous. Furthermore, growing the zeolite surface area has no discernible effect on the adsorption energies in all configurations. The ZAS composite may be used as a low-cost substitute adsorbent for the removal of anionic dyes from industrial wastewater at lower dye concentrations, according to the experimental results. Adsorption of CR dye onto Z, AS, and ZAS adsorbents was adequately explained by pseudo-second-order kinetics and the Langmuir isotherm. The sorption mechanism was also evaluated using Weber’s intra-particle diffusion module. Finally, field testing revealed that the newly synthesized adsorbent was 98.0% efficient at extracting dyes from industrial wastewater, proving the foundation of modern eco-friendly materials that aid in the reuse of industrial wastewater.

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“… 8 The second segment was associated with very limited variation in the observed releasing rate, showing a recognizable state of equilibration and the maximum releasing capacity for the loaded drug ( Figure 5 A). The release in this stage was limited because of the slow diffusion of the entrapped drug molecules within the cellulose matrix or formation of a complex with the essential active functional groups 20 , 24 as reported by FT-IR analysis. Additionally, the predicted entrapping of the OL drug as intercalated molecules between the kaolinite units had an effective role in reducing the diffusion rates of the drug into the buffer solutions.…”

Section: Resultsmentioning

confidence: 99%

“…The release profile was followed by inspection of regular samples from the solutions (3 mL) after regular releasing intervals to detect the diffused OL molecules using the UV–vis spectrophotometer at an adjusted λ max of 209 nm. The percentages of the released OL molecules were calculated using eq 7 ( 20 ) …”

Section: Experimental Workmentioning

confidence: 99%

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

et al. 2020

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Kaolinite layers were exfoliated as single sheets and admixed with cellulose fibers, forming an advanced exfoliated kaolinite/cellulose fiber (EXK/CF) composite, which was characterized as a promising carrier for the oxaliplatin (OL) drug to induce safety as well as the therapeutic effect. The EXK/CF composite exhibited promising loading capacity and achieved an experimental value of 670 mg/g and an expected theoretical value of 704.4 mg/g. The loading behavior of OL using the EXK/CF composite followed the pseudo-first-order kinetic model and the Langmuir equilibrium model, achieving an adsorption energy of 7.7 kJ/mol. This suggested physisorption and homogeneous loading behavior of the OL molecules in a monolayer form. The release profile of OL from EXK/CF continued for about 100 h with maximum release percentages of 86.4 and 95.2% in the phosphate and acetate buffers, respectively. The determined diffusion exponent from the Korsmeyer–Peppas kinetic model suggested non-Fickian transport behavior of the OL molecules and releasing behavior controlled by erosion as well as diffusion mechanisms. Regarding the cytotoxic effect, the EXK/CF composite has a high safety impact on the normal colorectal cells (CCD-18Co) and higher toxic impacts on the colorectal cancer cell (HCT116) than the free oxaliplatin drug.

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Insight into novel β-cyclodextrin-grafted-poly (N-vinylcaprolactam) nanogel structures as advanced carriers for 5-fluorouracil: Equilibrium behavior and pharmacokinetic modeling

Cited by 91 publications

References 48 publications

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Fabrication and Application of Zeolite/Acanthophora Spicifera Nanoporous Composite for Adsorption of Congo Red Dye from Wastewater

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

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Insight into novel β-cyclodextrin-grafted-poly (N-vinylcaprolactam) nanogel structures as advanced carriers for 5-fluorouracil: Equilibrium behavior and pharmacokinetic modeling

Cited by 91 publications

References 48 publications

Insight into the Loading Properties of Na+ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading Properties of Na+ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Fabrication and Application of Zeolite/Acanthophora Spicifera Nanoporous Composite for Adsorption of Congo Red Dye from Wastewater

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

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Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity