Insight into response of ion-exchanger-based electrodes sensitive to highly lipophilic physiologically active amines

Ion exchanger‐based electrodes for determination of highly lipophilic physiologically active amines: Peculiarities of functioning and ways for improving analytical characteristics

“…As for the influence of the conditioning and measurement mode on the response slope, potential drift, and lower detection limit value, these issues were not studied in any of the cited works. At the same time, as we showed in [9] the characteristics of electrodes sensitive to cations of highly lipophilic amines very much depend on the specific conditions of their use and can be significantly improved by optimizing them.…”

“…All measurements were carried out in a galvanic cell with transfer at 20 � 2 °C using a saturated Ag/AgCl reference electrode, as described in [9].…”

“…In addition, quite significant opportunities to control the characteristics of such electrodes are provided by the choice of plasticizer [7]. However, as we have shown earlier, electrodes reversible to highly hydrophobic ions have their own specific behaviour, which is caused by the possibility of co-extraction of the analyte into the membrane [8,9]. Therefore, their analytical characteristics significantly depend on the measurement conditions, primarily on the choice of pH value.…”